Patents by Inventor Joshua H. Lipschutz

Joshua H. Lipschutz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AAV VECTORS EXPRESSING SEC10 FOR TREATING KIDNEY DAMAGE
    Publication number: 20150374851
    Abstract: A method for enhancing repair of damaged mammalian tubular epithelial cells involves delivering to the tubular epithelial cells of a subject in need thereof a composition comprising an adeno-associated virus (AAV) comprising an AAV capsid having an amino acid sequence of a selected AAV serotype, and a minigene having AAV inverted terminal repeats and a Sec10 gene operatively linked to regulatory sequences that direct expression of Sec10 in the epithelial cells. In one embodiment, delivery is accomplished by retrograde intrauretal injection. In an embodiment the AAV vector includes a capsid of AAV serotype 2/8. Therapeutic compositions containing such AAV are provided.
    Type: Application
    Filed: July 1, 2015
    Publication date: December 31, 2015
    Inventors: Joshua H. Lipschutz, Jean Bennett, Daniel C. Chung
  • AAV Vectors Expressing SEC10 for Treating Kidney Damage
    Publication number: 20120244127
    Abstract: A method for enhancing repair of damaged mammalian tubular epithelial cells involves delivering to the tubular epithelial cells of a subject in need thereof a composition comprising an adeno-associated virus (AAV) comprising an AAV capsid having an amino acid sequence of a selected AAV serotype, and a minigene having AAV inverted terminal repeats and a Sec10 gene operatively linked to regulatory sequences that direct expression of Sec10 in the epithelial cells. In one embodiment, delivery is accomplished by retrograde intrauretal injection. In an embodiment the AAV vector includes a capsid of AAV serotype 2/8. Therapeutic compositions containing such AAV are provided.
    Type: Application
    Filed: September 30, 2010
    Publication date: September 27, 2012
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Joshua H. Lipschutz, Jean Bennett, Daniel C. Chung