Abstract: Compounds of formula I for treating, preventing or managing cancer are disclosed. Also disclosed are methods of treating, preventing or managing cancer, such as leukemia, comprising administering the compounds. In certain embodiments, the method of treatment comprise administering a compound provided herein in combination with a second agent. Pharmaceutical compositions and single unit dosage forms comprising the compounds are also disclosed.

Abstract: System and method for analyzing position data and fuel injector data from a vehicle equipped with a geographical position system (GPS) and fuel injector sensors to enable fuel use patterns of the vehicle to be analyzed. Data defining a flow of fuel through the vehicle's fuel injectors is combined with temporal data and GPS data to produce fuel use encoded GPS data that is transmitted to a remote computer. The fuel use encoded GPS data can be analyzed to determine how much fuel was used by the vehicle during off road use to enable proper fuel tax computations to be performed. The data can also be used to evaluate the mechanical condition of a vehicle. By monitoring fuel use for a trip repeated numerous times, a decrease in fuel efficiency may indicate a mechanical problem (dirty injectors, fouled spark plugs, etc).

Abstract: Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.

Abstract: Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.

Abstract: Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.

Abstract: System and method for analyzing position data and fuel injector data from a vehicle equipped with a geographical position system (GPS) and fuel injector sensors to enable fuel use patterns of the vehicle to be analyzed. Data defining a flow of fuel through the vehicle's fuel injectors is combined with temporal data and GPS data to produce fuel use encoded GPS data that is transmitted to a remote computer. The fuel use encoded GPS data can be analyzed to determine how much fuel was used by the vehicle during off road use to enable proper fuel tax computations to be performed. The data can also be used to evaluate the mechanical condition of a vehicle. By monitoring fuel use for a trip repeated numerous times, a decrease in fuel efficiency may indicate a mechanical problem (dirty injectors, fouled spark plugs, etc).

Abstract: A cargo transportation device includes a lift assembly for raising and lowering cargo and an operator cabin in which an operator controls the lift assembly. A load backrest is coupled to the cabin, and an automatic data collection device, which is configured to interrogate wireless communication devices, is coupled to the load backrest. The cargo transportation device includes a computing device having logic for controlling the automatic data collection device and logic for controlling the lift assembly, and a display device in communication with the computing device. The display device is coupled to the cabin and configured to provide the operator with information from the computing device.

Abstract: The present invention is a modular handheld device. The modular handheld comprises a console and a keypad/battery module that acts with the console. The handheld can have other module parts. For example different modular handles can be attached to the handheld. The user or user organization has the option to select from one or more smaller keypad/battery battery modules and/or one or more larger keypad/battery modules with more battery capacity. The appropriate keypad/battery module is selected based on the needs of the particular user or application. This allows an organization to have multiple handheld configurations which utilize the same core computing engine, thus greatly reducing the number of IT platforms that need to be supported. By combining the display, processor, scan engines and radios into a console and separating the keypad and batteries into a “personality module” many different handhelds can be customized from a single console.