Patents by Inventor Joshua Hihath
Joshua Hihath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11943940Abstract: A nanostructured cross-wire memory architecture is provided that can interface with conventional semiconductor technologies and be electrically accessed and read. The architecture links lower and upper sets of generally parallel nanowires oriented crosswise, with a memory element that has a characteristic conductance. Each nanowire end is attached to an electrode. Conductance of the linkages in the gap between the wires encodes the information. The nanowires may be highly-conductive, self-assembled, nucleic acid-based nanowires enhanced with dopants including metal ions, carbon, metal nanoparticles and intercalators. Conductance of the memory elements can be controlled by sequence, length, conformation, doping, and number of pathways between nanowires. A diode can also be connected in series with each of the memory elements. Linkers may also be redox or electroactive switching molecules or nanoparticles where the charge state changes the resistance of the memory element.Type: GrantFiled: July 11, 2019Date of Patent: March 26, 2024Assignees: The Regents of the University of California, University of Washington, Emory UniversityInventors: Joshua Hihath, Manjeri P. Anantram, Yonggang Ke
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Patent number: 11828745Abstract: A micro-electromechanical platform and array system and methods for identifying microbial species with single molecule electrical conductance measurements are provided. The electromechanical platform has a two-tier actuation mechanism with a long stroke provided by a comb drive and a fine stroke provided by an in-plane flexural actuator. The platform is capable of making contact with a single-molecule, applying a bias, measuring the current, and performing a large number of measurements for statistical analysis. The system is capable of detecting any microbial species without requiring enzymatic amplification by detecting specific RNA sequences, for example. With oligonucleotide target molecules, the conductance is extremely sensitive to the sequence so even single-nucleotide polymorphisms can be identified. The system can also discern between subspecies using the same DNA probe.Type: GrantFiled: March 24, 2021Date of Patent: November 28, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Joshua Hihath, Xiaoguang Liu, Maria Louise Marco
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Patent number: 11640014Abstract: Various metamaterials are disclosed. An example metamaterial comprises: a first portion with a plurality of nanoparticles; a second portion with a plurality of molecules configured to interlink with the plurality of nanoparticles; and a signal generator configured to provide a signal to the material. The first portion and the second portion of the material are configured to form a hybrid molecule-nanoparticle super-lattice. In some implementations, the first portion of the material is configured to have a mass configured to achieve, at least in part, a designated resonance frequency. The second portion of the material is, in some implementations, configured to have a molecular stiffness configured to achieve, at least in part, the designated resonance frequency. The signal generator is, in some implementations, configured to generate radio frequency (RF) signals.Type: GrantFiled: September 28, 2020Date of Patent: May 2, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Joshua Hihath, Omeed Momeni, Davide Donadio
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Publication number: 20220005870Abstract: A nanostructured cross-wire memory architecture is provided that can interface with conventional semiconductor technologies and be electrically accessed and read. The architecture links lower and upper sets of generally parallel nanowires oriented crosswise, with a memory element that has a characteristic conductance. Each nanowire end is attached to an electrode. Conductance of the linkages in the gap between the wires encodes the information. The nanowires may be highly-conductive, self-assembled, nucleic acid-based nanowires enhanced with dopants including metal ions, carbon, metal nanoparticles and intercalators. Conductance of the memory elements can be controlled by sequence, length, conformation, doping, and number of pathways between nanowires. A diode can also be connected in series with each of the memory elements. Linkers may also be redox or electroactive switching molecules or nanoparticles where the charge state changes the resistance of the memory element.Type: ApplicationFiled: July 11, 2019Publication date: January 6, 2022Applicants: The Regents of the University of California, University of Washington, Emory UniversityInventors: Joshua Hihath, Manjeri P. Anantram, Yonggang Ke
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Patent number: 11209383Abstract: A biosensor platform apparatus and method are provided that can detect, purify and identify nucleic acid (DNA and RNA) biomarkers in complex biological fluids. The methods use a two-stage molecular based approach. The first stage screens for specific nucleic acid-based biomarkers in complex biological fluids by electrochemical detection of DNA:RNA hybridization and facilitates the removal of remaining complex media constituents. The first stage utilizes probes within a tunable nanoporous electrode. The second stage identifies the purified specific hybrids by single-molecule conductance measurements via break junction scanning. Identification can be assisted with a library of conductance measurements. The methods can provide strain level information that can be used for identifying anti-microbial resistance in detected pathogens. Collection of RNA targets allows for biomarker detection and identification without the need for amplification and can provide information about the viability of the sample organism.Type: GrantFiled: October 31, 2018Date of Patent: December 28, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Erkin Seker, Joshua Hihath, Maria Marco, Paul Feldstein, Pallavi Daggumati, Yuanhui Li, Zimple Matharu, Juan Artes Vivancos
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Publication number: 20210255164Abstract: A micro-electromechanical platform and array system and methods for identifying microbial species with single molecule electrical conductance measurements are provided. The electromechanical platform has a two-tier actuation mechanism with a long stroke provided by a comb drive and a fine stroke provided by an in-plane flexural actuator. The platform is capable of making contact with a single-molecule, applying a bias, measuring the current, and performing a large number of measurements for statistical analysis. The system is capable of detecting any microbial species without requiring enzymatic amplification by detecting specific RNA sequences, for example. With oligonucleotide target molecules, the conductance is extremely sensitive to the sequence so even single-nucleotide polymorphisms can be identified. The system can also discern between subspecies using the same DNA probe.Type: ApplicationFiled: March 24, 2021Publication date: August 19, 2021Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Joshua Hihath, Xiaoguang Liu, Maria Louise Marco
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Patent number: 10989705Abstract: A micro-electromechanical platform and array system and methods for identifying microbial species with single molecule electrical conductance measurements are provided. The electromechanical platform has a two-tier actuation mechanism with a long stroke provided by a comb drive and a fine stroke provided by an in-plane flexural actuator. The platform is capable of making contact with a single-molecule, applying a bias, measuring the current, and performing a large number of measurements for statistical analysis. The system is capable of detecting any microbial species without requiring enzymatic amplification by detecting specific RNA sequences, for example. With oligonucleotide target molecules, the conductance is extremely sensitive to the sequence so even single-nucleotide polymorphisms can be identified. The system can also discern between subspecies using the same DNA probe.Type: GrantFiled: July 11, 2017Date of Patent: April 27, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Joshua Hihath, Xiaoguang Liu, Maria Louise Marco
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Publication number: 20210088693Abstract: Various metamaterials are disclosed. An example metamaterial comprises: a first portion with a plurality of nanoparticles; a second portion with a plurality of molecules configured to interlink with the plurality of nanoparticles; and a signal generator configured to provide a signal to the material. The first portion and the second portion of the material are configured to form a hybrid molecule-nanoparticle super-lattice. In some implementations, the first portion of the material is configured to have a mass configured to achieve, at least in part, a designated resonance frequency. The second portion of the material is, in some implementations, configured to have a molecular stiffness configured to achieve, at least in part, the designated resonance frequency. The signal generator is, in some implementations, configured to generate radio frequency (RF) signals.Type: ApplicationFiled: September 28, 2020Publication date: March 25, 2021Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Joshua Hihath, Omeed Momeni, Davide Donadio
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Patent number: 10400270Abstract: A technique that uses nanotechnology to electrically detect and identify RNA sequences without the need for using enzymatic amplification methods or fluorescent labels. The technique may be scaled into large multiplexed arrays for high-throughput and rapid screening. The technique is further able to differentiate closely related variants of a given bacterial or viral species or strain. This technique addresses the need for a quick, efficient, and inexpensive bacterial and viral detection and identification system.Type: GrantFiled: September 12, 2017Date of Patent: September 3, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Andre Knoesen, Paul Alexander Feldstein, Joshua Hihath, Erkin Seker, Maria Louise Marco, Bryce William Falk
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Publication number: 20190137434Abstract: A biosensor platform apparatus and method are provided that can detect, purify and identify nucleic acid (DNA and RNA) biomarkers in complex biological fluids. The methods use a two-stage molecular based approach. The first stage screens for specific nucleic acid-based biomarkers in complex biological fluids by electrochemical detection of DNA:RNA hybridization and facilitates the removal of remaining complex media constituents. The first stage utilizes probes within a tunable nanoporous electrode. The second stage identifies the purified specific hybrids by single-molecule conductance measurements via break junction scanning. Identification can be assisted with a library of conductance measurements. The methods can provide strain level information that can be used for identifying anti-microbial resistance in detected pathogens. Collection of RNA targets allows for biomarker detection and identification without the need for amplification and can provide information about the viability of the sample organism.Type: ApplicationFiled: October 31, 2018Publication date: May 9, 2019Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Erkin Seker, Joshua Hihath, Maria Marco, Paul Feldstein, Pallavi Daggumati, Yuanhui Li, Zimple Matharu, Juan Artes Vivancos
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Publication number: 20180066310Abstract: A technique that uses nanotechnology to electrically detect and identify RNA sequences without the need for using enzymatic amplification methods or fluorescent labels. The technique may be scaled into large multiplexed arrays for high-throughput and rapid screening. The technique is further able to differentiate closely related variants of a given bacterial or viral species or strain. This technique addresses the need for a quick, efficient, and inexpensive bacterial and viral detection and identification system.Type: ApplicationFiled: September 12, 2017Publication date: March 8, 2018Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Andre Knoesen, Paul Alexander Feldstein, Joshua Hihath, Erkin Seker, Maria Louise Marco, Bryce William Falk
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Publication number: 20170343531Abstract: A micro-electromechanical platform and array system and methods for identifying microbial species with single molecule electrical conductance measurements are provided. The electromechanical platform has a two-tier actuation mechanism with a long stroke provided by a comb drive and a fine stroke provided by an in-plane flexural actuator. The platform is capable of making contact with a single-molecule, applying a bias, measuring the current, and performing a large number of measurements for statistical analysis. The system is capable of detecting any microbial species without requiring enzymatic amplification by detecting specific RNA sequences, for example. With oligonucleotide target molecules, the conductance is extremely sensitive to the sequence so even single-nucleotide polymorphisms can be identified. The system can also discern between subspecies using the same DNA probe.Type: ApplicationFiled: July 11, 2017Publication date: November 30, 2017Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Joshua Hihath, Xiaoguang Liu, Maria Louise Marco
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Patent number: 9803234Abstract: A technique that uses nanotechnology to electrically detect and identify RNA sequences without the need for using enzymatic amplification methods or fluorescent labels. The technique may be scaled into large multiplexed arrays for high-throughput and rapid screening. The technique is further able to differentiate closely related variants of a given bacterial or viral species or strain. This technique addresses the need for a quick, efficient, and inexpensive bacterial and viral detection and identification system.Type: GrantFiled: April 1, 2015Date of Patent: October 31, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Andre Knoesen, Paul Alexander Feldstein, Joshua Hihath, Erkin Seker, Maria Louise Marco, Bryce William Falk
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Publication number: 20150275279Abstract: A technique that uses nanotechnology to electrically detect and identify RNA sequences without the need for using enzymatic amplification methods or fluorescent labels. The technique may be scaled into large multiplexed arrays for high-throughput and rapid screening. The technique is further able to differentiate closely related variants of a given bacterial or viral species or strain. This technique addresses the need for a quick, efficient, and inexpensive bacterial and viral detection and identification system.Type: ApplicationFiled: April 1, 2015Publication date: October 1, 2015Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Andre Knoesen, Paul Alexander Feldstein, Joshua Hihath, Erkin Seker, Maria Louise Marco, Bryce William Falk