Patents by Inventor Joshua Klonoski

Joshua Klonoski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for amplifying a detectable signal
    Patent number: 9359637
    Abstract: Methods and materials are disclosed relating to an improved method for amplifying a signal in a diagnostic assay for a nucleic acid, comprising the steps of providing an amplification polymer bound to a nucleic acid analyte, wherein the amplification polymer comprises a plurality of amine groups; binding amine groups on the amplification polymer with a detectable label complex; and reacting under high salt conditions an acetylating compound with amine groups not bound with a detectable label complex.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: June 7, 2016
    Assignee: Great Basin Scientific, Inc.
    Inventors: Robert D. Jenison, Joshua Klonoski, Anthony R. Torres
  • METHODS AND COMPOSITIONS FOR AMPLIFYING A DETECTABLE SIGNAL
    Publication number: 20160076080
    Abstract: Methods and materials are disclosed relating to an improved method for amplifying a signal in a diagnostic assay for a nucleic acid, comprising the steps of providing an amplification polymer bound to a nucleic acid analyte, wherein the amplification polymer comprises a plurality of amine groups; binding amine groups on the amplification polymer with a detectable label complex; and reacting under high salt conditions an acetylating compound with amine groups not bound with a detectable label complex.
    Type: Application
    Filed: November 23, 2015
    Publication date: March 17, 2016
    Inventors: Robert D. Jenison, Joshua Klonoski, Anthony R. Torres
  • Methods and compositions for amplifying a detectable signal
    Patent number: 9200312
    Abstract: Methods and materials are disclosed relating to an improved method for amplifying a signal in a diagnostic assay for a nucleic acid, comprising the steps of providing an amplification polymer bound to a nucleic acid analyte, wherein the amplification polymer comprises a plurality of amine groups; binding amine groups on the amplification polymer with a detectable label complex; and reacting under high salt conditions an acetylating compound with amine groups not bound with a detectable label complex.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: December 1, 2015
    Assignee: Great Basin Scientific Corporation
    Inventors: Robert D. Jenison, Joshua Klonoski, Anthony R. Torres
  • METHODS AND COMPOSITIONS FOR AMPLIFYING A DETECTABLE SIGNAL
    Publication number: 20140038200
    Abstract: Methods and materials are disclosed relating to an improved method for amplifying a signal in a diagnostic assay for a nucleic acid, comprising the steps of providing an amplification polymer bound to a nucleic acid analyte, wherein the amplification polymer comprises a plurality of amine groups; binding amine groups on the amplification polymer with a detectable label complex; and reacting under high salt conditions an acetylating compound with amine groups not bound with a detectable label complex.
    Type: Application
    Filed: October 3, 2013
    Publication date: February 6, 2014
    Applicant: Great Basin Scientific
    Inventors: Robert D. Jenison, Joshua Klonoski, Anthony R. Torres
  • Methods and compositions for amplifying a detectable signal
    Patent number: 8574833
    Abstract: Methods and materials are disclosed relating to an improved method for amplifying a signal in a diagnostic assay for a nucleic acid, comprising the steps of providing an amplification polymer bound to a nucleic acid analyte, wherein the amplification polymer comprises a plurality of amine groups; binding amine groups on the amplification polymer with a detectable label complex; and reacting under high salt conditions an acetylating compound with amine groups not bound with a detectable label complex.
    Type: Grant
    Filed: November 26, 2008
    Date of Patent: November 5, 2013
    Assignee: Great Basin Scientific
    Inventors: Robert D. Jenison, Joshua Klonoski, Anthony R. Torres
  • METHODS AND COMPOSITIONS FOR AMPLIFYING A DETECTABLE SIGNAL
    Publication number: 20110039260
    Abstract: Methods and materials are disclosed relating to an improved method for amplifying a signal in a diagnostic assay for a nucleic acid, comprising the steps of providing an amplification polymer bound to a nucleic acid analyte, wherein the amplification polymer comprises a plurality of amine groups; binding amine groups on the amplification polymer with a detectable label complex; and reacting under high salt conditions an acetylating compound with amine groups not bound with a detectable label complex.
    Type: Application
    Filed: November 26, 2008
    Publication date: February 17, 2011
    Applicant: Great Basin Scientific
    Inventors: Robert D. Jenison, Joshua Klonoski, Anthony R. Torres
  • METHODS AND COMPOSITIONS FOR SIGNAL ENHANCEMENT USING MULTIVALENT INTERACTIONS
    Publication number: 20100304387
    Abstract: Methods and materials are disclosed relating to an improved method for amplifying a signal in a diagnostic assay for an analyte, using an amplification polymer that multivalently binds to one or more non-analyte-specific binding site of the multivalent bridge conjugate, if present on the solid support.
    Type: Application
    Filed: November 26, 2008
    Publication date: December 2, 2010
    Inventors: Robert D. Jenison, Joshua Klonoski