Patents by Inventor Joshua L. Andersen

Joshua L. Andersen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell Cycle Arrest and Apoptosis
    Publication number: 20120122770
    Abstract: The HIV-1 accessory gene vpr encodes a conserved 96-amino acid protein that is necessary and sufficient for the HIV-1-induced block of cellular proliferation and induction of apoptosis. Expression of vpr in CD4.sup.+ lymphocytes results in G2 arrest, followed by apoptosis. ATR, as a cellular factor that mediates Vpr-induced cell cycle arrest, is required for activation of the Breast Cancer-Associated Protein-1 (BRCA1). In addition, the Growth Arrest and DNA Damage protein (GADD45) is upregulated by Vpr in an ATR-dependent manner. Posttranscriptional silencing of either ATR or GADD45 leads to nearly complete suppression of the pro-apoptotic and/or cell cycle arrest effect of Vpr.
    Type: Application
    Filed: July 4, 2011
    Publication date: May 17, 2012
    Inventors: Vicente Planelles, Joshua L. Andersen, Erik Zimmerman
  • Cell cycle arrest and apoptosis
    Patent number: 7973018
    Abstract: The HIV-1 accessory gene vpr encodes a conserved 96-amino acid protein that is necessary and sufficient for the HIV-1-induced block of cellular proliferation and induction of apoptosis. Expression of vpr in CD4+ lymphocytes results in G2 arrest, followed by apoptosis. ATR, as a cellular factor that mediates Vpr-induced cell cycle arrest, is required for activation of the Breast Cancer-Associated Protein-1 (BRCA1). In addition, the Growth Arrest and DNA Damage protein (GADD45) is upregulated by Vpr in an ATR-dependent manner. Posttranscriptional silencing of either ATR or GADD45 leads to nearly complete suppression of the pro-apoptotic and/or cell cycle arrest effect of Vpr.
    Type: Grant
    Filed: October 21, 2004
    Date of Patent: July 5, 2011
    Assignee: University of Utah Research Foundation
    Inventors: Vicente Planelles, Joshua L. Andersen, Erik Zimmerman
  • Cell Cycle Arrest and Apoptosis
    Publication number: 20080300201
    Abstract: The HIV-1 accessory gene vpr encodes a conserved 96-amino acid protein that is necessary and sufficient for the HIV-1-induced block of cellular proliferation and induction of apoptosis. Expression of vpr in CD4+ lymphocytes results in G2 arrest, followed by apoptosis. ATR, as a cellular factor that mediates Vpr-induced cell cycle arrest, is required for activation of the Breast Cancer-Associated Protein-1 (BRCA1). In addition, the Growth Arrest and DNA Damage protein (GADD45) is upregulated by Vpr in an ATR-dependent manner. Posttranscriptional silencing of either ATR or GADD45 leads to nearly complete suppression of the pro-apoptotic and/or cell cycle arrest effect of Vpr.
    Type: Application
    Filed: October 21, 2004
    Publication date: December 4, 2008
    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Vicente Planelles, Joshua L. Andersen, Erik S. Zimmerman