Abstract: A medical system may include a left atrial appendage closure device including an expandable framework configured to shift between a collapsed delivery configuration and an expanded deployed configuration. The expandable framework has an outer diameter in the expanded deployed configuration. The medical system also includes a cinching member configured to shift between a compressed delivery configuration and an expanded configuration. The cinching member is ring shaped with an inner diameter in the expanded configuration that is larger than the outer diameter of the left atrial appendage closure device, and the cinching member has a plurality of tissue engagement elements defined on an outer surface thereof.

Abstract: A delivery system for delivering, adjusting, and/or recapturing a stent-valve includes an inner shaft and an expandable stent-valve coupled to the inner shaft. The stent-valve has an upper portion, a lower portion, and a valve. The delivery system also includes a distal sheath disposed over at least the lower portion, a proximal sheath disposed over at least the upper portion, and at least one cinching member coupled to the stent-valve and extending through one of the inner shaft, the distal sheath, or the proximal sheath. The upper and lower portions of the stent-valve are configured to move to an expanded configuration when the proximal and distal sheaths are withdrawn, respectively. After at least a portion of the stent-valve has been moved to the expanded configuration, the at least one cinching member is configured to at least partially radially compress at least a portion of the stent-valve.

Abstract: An example occlusive implant is disclosed. The example occlusive implant includes an expandable framework configured to shift between a first configuration and an expanded configuration and a fixation member disposed along the expandable framework. The fixation member includes a first engagement portion and an anchor portion. Further, the first engagement portion is designed to be secured to the expandable framework and the anchor portion extends away from an outer surface of the expandable framework.

Abstract: A pacing system configured to sense cardiac activity and to deliver pacing therapy to a patient's heart. The pacing system may comprise a first electrode configured to be positioned in a first chamber of the heart and configured to deliver a first pacing therapy to the first chamber of the heart and a second electrode configured to be positioned in the left atrial appendage and configured to deliver a second pacing therapy to the left atrial appendage. The processing module of the pacing system may be configured to time a delivery of the first pacing therapy based on a first timing fiducial and a delivery of the second pacing therapy based on a determined pacing delay between the first pacing therapy and the second pacing therapy. The determined pacing delay may be configured to maximize a flow of blood into and/or out of the left atrial appendage.

Abstract: A medical device for causing blood flow within a left atrial appendage (LAA) includes a flow energy capture element adapted to capture energy caused by movement within the heart. A transmission element is operably coupled to the flow energy capture element, the transmission element adapted to utilize the captured energy to cause blood flow within the LAA.

Abstract: A left atrial appendage (LAA) ligation device is adapted for ligating the LAA via a trans-septal approach, the LAA including an ostium. The LAA ligation device includes a spiral ligation element extending from an end point disposed at a periphery of the spiral ligation element to a center point of the spiral ligation element, the spiral ligation element having a diameter defined by the periphery and a length defined between the periphery and the center point. A delivery device is adapted to releasably secure the spiral ligation element and to enable rotation of the spiral ligation device.

Abstract: A left atrial appendage closure (LAAC) device includes an expandable member that defines a profile of the LAAC device and is moveable between a minimal diameter and a maximum diameter, the expandable member adapted to move to a deployment diameter that is intermediate the minimal diameter and the maximum diameter and that is limited by dimensions of a left atrial appendage (LAA) in which the LAAC device is deployed. A fabric extends over at least a portion of the expandable member and is adapted to accommodate changes in the expandable member between the minimal diameter and the increased diameter.

Abstract: An occlusive implant system may include a catheter having a lumen extending from a proximal opening to a distal opening, a core wire slidably disposed within the lumen, and an occlusive implant having an expandable framework configured to shift between a collapsed configuration and an expanded configuration, and an occlusive element disposed on the expandable framework. The expandable framework may include a plurality of anchor members extending radially outward from the expandable framework, at least some of the plurality of anchor members each have a barb projecting circumferentially therefrom. The occlusive implant may be releasably connected to a distal portion of the core wire.

Abstract: Blood stagnation within a left atrial appendage (LAA) may be reduced by creating movement within the LAA. A variety of different actuatable devices, including magnetically actuated devices, may be implanted within the LAA. The actuatable device may be caused to become actuated, thereby causing the motion within the LAA. In some cases, causing the actuatable device to become actuated may include application of a magnetic field. In some cases, causing the actuatable device to become actuated may include subjecting the actuatable device to blood flow within the LAA.

Abstract: Blood stagnation within a left atrial appendage (LAA) may be reduced by creating movement within the LAA. A variety of different actuatable devices, including magnetically actuated devices, may be implanted within the LAA. The actuatable device may be caused to become actuated, thereby causing the motion within the LAA. In some cases, causing the actuatable device to become actuated may include application of a magnetic field. In some cases, causing the actuatable device to become actuated may include subjecting the actuatable device to blood flow within the LAA.

Abstract: Example medical devices and methods of making example medical devices are disclosed. An example medical device includes a frame configured to be secured to cardiac tissue, wherein the frame includes a fatigue resistant nickel-titanium alloy that is heat set at a temp in the range of 450-550 degrees Celsius.

Abstract: An implant for occluding a left atrial appendage may include an expandable framework configured to shift between a collapsed configuration and an expanded configuration, wherein the expandable framework includes an attachment point configured to secure the expandable framework to a delivery device, and an occlusive element disposed on a proximal portion of the expandable framework, wherein the occlusive element covers the attachment point.

Abstract: An example occlusive implant is disclosed. The example occlusive implant includes an expandable framework configured to shift between a collapsed configuration and an expanded configuration, wherein the expandable framework includes a plurality of strut members circumferentially spaced around a longitudinal axis of the expandable framework, wherein one or more of the plurality of strut members includes a first twisted portion and a face portion. The occlusive implant also includes a plurality of fixation members disposed along the face portion of one or more of the plurality of strut members.

Abstract: Implanting a left atrial appendage closure (LAAC) device within a patient's left atrial appendage (LAA) may include advancing an assembly to a position proximate the patient's LAA. The assembly includes an LAAC device releasably secured to an LAAC delivery catheter, and one or more ultrasound transducers disposed relative to the LAAC delivery catheter. Once the LAAC device is deployed, the ultrasound transducers may be rotated relative to the LAAC device to look for leaks between the LAAC device and the LAA. In some cases, the LAAC device may be repositioned relative to the LAA when excessive leaks are found via ultrasound.

Abstract: An implantable medical device such as, but not limited to an LAAC (left atrial appendage closure) device includes an expandable frame that is moveable between a collapsed configuration for delivery and an expanded configuration for deployment, the expandable frame having a variable diameter in the expanded configuration. The expandable frame includes a central member, and a grouping of arcuate articulating members joined at one end to the first central member, each of the first grouping of arcuate articulating members extending outwardly from the first central member. A covering is disposed relative to the first grouping of arcuate articulating members.

Abstract: Solutions for reducing irritation and/or trauma which may result upon contact of an implanted implantable device with tissue surrounding or adjacent to the implantable device. Various embodiments include features which allow a tangential or otherwise atraumatic contact of the implantable device with the tissue, in contrast with a sharper contact which may occur with prior art implantable devices. The broad principles are applicable to annuloplasty devices, and have other broader applications as well.

Abstract: An implantable medical device such as but not limited to a left atrial appendage closure (LAAC) device includes an expandable frame that is movable between a collapsed configuration for delivery and an expanded configuration for deployment. The expandable frame may include a plurality of articulating members that are biased into the expanded configuration. The expandable frame may include a biasing member. The LAAC device includes a membrane or covering that spans across an end of the expandable frame. In some cases, the LAAC device may be adjustable to better fit a non-circular ostium.

Abstract: An implantable medical device includes an expandable frame that is expandable between a collapsed configuration for delivery and an expanded configuration for deployment, the expandable frame including a periphery defined by the expandable frame. A covering spans at least part of the expandable frame. An expandable element is secured relative to the periphery, the expandable element is adapted to seal against an irregular body opening such as an irregular-shaped ostium of a patient's LAA (left atrial appendage).

Abstract: An implantable medical device such as but not limited to a left atrial appendage closure (LAAC) device includes an expandable frame that is movable between a collapsed configuration for delivery and an expanded configuration for deployment. The expandable frame may include a plurality of articulating members that are biased into the expanded configuration. The expandable frame may include a biasing member. The LAAC device includes a membrane or covering that spans across an end of the expandable frame.

Abstract: A medical device system may include an occlusive implant including a central hub and a plurality of elongate members configured to shift between extended and radially expanded configurations. The central hub includes a plurality of conduits extending from a proximal end to a radially outward facing surface. The plurality of elongate members is configured to extend through the conduits in the radially expanded configuration. An implant remodeling tool may include an elongate sheath having at least one lumen, a plunger guide, and a plurality of plunger shafts extending from the at least one lumen through the plunger guide. The plunger guide is configured to direct the plunger shafts radially outward as the plunger shafts are advanced distally. The plunger shafts are configured to engage a medical implant and urge at least a portion of the implant radially outward.