Abstract: An implantable medical device such as but not limited to a left atrial appendage closure (LAAC) device includes an expandable frame that is movable between a collapsed configuration for delivery and an expanded configuration for deployment. The expandable frame may include a plurality of articulating members that are biased into the expanded configuration. The expandable frame may include a biasing member. The LAAC device includes a membrane or covering that spans across an end of the expandable frame.

Abstract: A medical device system may include an occlusive implant including a central hub and a plurality of elongate members configured to shift between extended and radially expanded configurations. The central hub includes a plurality of conduits extending from a proximal end to a radially outward facing surface. The plurality of elongate members is configured to extend through the conduits in the radially expanded configuration. An implant remodeling tool may include an elongate sheath having at least one lumen, a plunger guide, and a plurality of plunger shafts extending from the at least one lumen through the plunger guide. The plunger guide is configured to direct the plunger shafts radially outward as the plunger shafts are advanced distally. The plunger shafts are configured to engage a medical implant and urge at least a portion of the implant radially outward.

Abstract: An implant for occluding a left atrial appendage may include an expandable framework configured to shift between a collapsed configuration and an expanded configuration, wherein the expandable framework includes an attachment point configured to secure the expandable framework to a delivery device, and an occlusive element disposed on a proximal portion of the expandable framework, wherein the occlusive element covers the attachment point.

Abstract: A medical implant for occluding a left atrial appendage may include an expandable framework configured to shift between a collapsed configuration and an expanded configuration. The expandable framework may include a plurality of interconnected struts and a plurality of anchor members extending radially outward from the plurality of interconnected struts in the expanded configuration. Each anchor member of the plurality of anchor members may include a base portion fixedly attached to the plurality of interconnected struts and an anchor tip portion. The anchor tip portion may include a central penetrating element and at least one tissue support element extending outward from the central penetrating element. The at least one tissue support element may be configured to be non-penetrating.

Abstract: An implantable medical device such as but not limited to a left atrial appendage closure (LAAC) device includes an expandable frame that is movable between a collapsed configuration for delivery and an expanded configuration for deployment. The expandable frame may include a plurality of frame members that are biased into the expanded configuration. The expandable frame may include a biasing member. The LAAC device includes a membrane or covering that spans across an end of the expandable frame.

Abstract: A medical implant for occluding a left atrial appendage may include an expandable framework configured to shift radially between a first configuration and a second configuration, and an occlusive element secured to the expandable framework. The framework includes a plurality of strut groups, each strut group comprising first and second joints, and first, second, and third struts. The first and second struts move laterally from a first position in the first configuration to a second position in the second configuration. The third strut is configured to shift radially from a first position in the first configuration to a second position in the second configuration. The first and second struts and a majority of the third struts of each strut group may be oriented parallel to each other in the first configuration and nonparallel to each other in the second configuration.

Abstract: A delivery system for deploying a medical implant includes a delivery catheter with a lumen, an elongate shaft axially slidably within the lumen, a housing attached to the elongate shaft, and an actuation element disposed within the housing and configured to axially advance and retract the elongate shaft. The actuation element is in direct contact with the elongate shaft and rotation of the actuation element causes axial movement of the elongate shaft.

Abstract: An example occlusive implant is disclosed. The example occlusive implant includes an expandable framework configured to shift between a collapsed configuration and an expanded configuration, wherein the expandable framework includes a plurality of strut members circumferentially spaced around a longitudinal axis of the expandable framework, wherein one or more of the plurality of strut members includes a first twisted portion and a face portion. The occlusive implant also includes a plurality of fixation members disposed along the face portion of one or more of the plurality of strut members.

Abstract: An example medical device for occluding the left atrial appendage is disclosed. The example medical device for occluding the left atrial appendage includes an expandable member having a first end region, a second end region and an inflation cavity. The example medical device includes at least one fixation member having a first end and a second end coupled to the expandable member. The at least one fixation member is configured to move from a delivery configuration to a deployed configuration in response to an expansion of the expandable member. Additionally, the example medical device includes a valve member extending at least partially into the inflation cavity and the expandable member is configured to expand and seal the opening of the left atrial appendage.

Abstract: An implantable medical device such as but not limited to a left atrial appendage closure (LAAC) device includes an expandable frame that is movable between a collapsed configuration for delivery and an expanded configuration for deployment, the expandable frame including a proximal portion, a distal portion and an intervening intermediate portion. The expandable frame includes a plurality of anchors extending about a periphery of the expandable frame. A primary covering extends over the proximal portion of the expandable frame and may interact with the plurality of anchors. A secondary covering extends over part of the expandable frame.

Abstract: A medical implant for occluding a left atrial appendage may include an expandable framework configured to shift between a collapsed configuration and an expanded configuration, and an occlusive element secured to the expandable framework. The expandable framework includes a proximal hub and a plurality of interconnected struts extending from the proximal hub, the plurality of interconnected struts defining a main body in the expanded configuration. The expandable framework includes a plurality of elongate anchoring appendages extending from the main body, the plurality of elongate anchoring appendages each including a plurality of anchoring barbs extending therefrom.

Abstract: A medical implant for occluding a left atrial appendage includes an expandable framework configured to shift between a first configuration and a second configuration, and an occlusive element secured to the expandable framework. The expandable framework includes a plurality of interconnected struts extending from a proximal hub. The plurality of interconnected struts includes a first plurality of struts and a second plurality of struts. In the second configuration, the first plurality of struts each extend radially along a first strut path from the proximal hub to one of a first plurality of strut intersections, and the second plurality of struts each extend radially along a second strut path from the proximal hub to one of a second plurality of strut intersections. In the second configuration, the first plurality of struts forms a depression in the expandable framework and the second plurality of struts extends into the depression.

Abstract: A method of manufacturing a medical implant for occluding a left atrial appendage may include cutting an expandable scaffold in a first configuration, wherein the expandable scaffold includes a plurality of struts having ends joined together at intersection points and a plurality of anchor members extending from the plurality of struts such that each anchor member extends from a medial portion of a strut of the plurality of struts, forming the expandable scaffold into a second configuration, wherein forming the expandable scaffold into the second configuration includes bending each anchor member along its bending axis, the bending axis being oriented parallel to a longitudinal axis of its respective strut of the plurality of struts, and heat setting the expandable scaffold in the second configuration. The method may include securing an occlusive element to the expandable scaffold.

Abstract: A latch locking and release system having a control knob operably coupled with a latch system, and a tubular latch release mechanism. The cross-section of the tubular latch release mechanism is shiftable between a locking configuration and a release configuration. In the locking configuration, the control knob maintains latches in the latch system in an engaged configuration, and is blocked from moving to allow the latches to be disengaged. In the release configuration, the control knob may be moved to allow the latches to be disengaged. The latch release mechanism and control knob may have further features preventing inadvertent actuation of the latch locking and release system to allow the latch system to be disengaged.

Abstract: An assembly for delivering an implantable medical device, the assembly includes an implantable medical device including an attachment feature and a delivery device that is adapted to releasably secure the implantable medical device, the delivery device including an attachment element adapted to create an interference fit with the attachment feature of the implantable medical device. The delivery device is adapted to enable a user to selectively disengage the interference fit between the attachment element of the delivery device and the attachment feature of the implantable medical device with a short linear motion when the delivery device is positioned proximate a delivery site for the implantable medical device.

Abstract: An implantable medical device includes an expandable frame that is moveable between a collapsed configuration for delivery and an expanded configuration for deployment. One or more proximally-facing fixation burrs are secured relative to the expandable frame. One or more distally-facing fixation burrs are secured relative to the expandable frame. The one or more proximally-facing fixation burrs and the one or more distally-facing fixation burrs together provide the implantable medical device with bi-directional stability.

Abstract: A medical implant including an expandable framework configured to shift between a collapsed configuration and an expanded configuration, the expandable framework comprising a plurality of interconnected struts defining a plurality of cells; and an occlusive element connected to the expandable framework and having an inner surface and an outer surface. The expandable framework may include a plurality of securement members projecting from the plurality of interconnected struts. One of the inner surface or the outer surface of the occlusive element may be in contact with the plurality of interconnected struts, and the other of the inner surface and the outer surface not in contact with the plurality of interconnected struts may lie against an opposing surface of each of the plurality of securement members. A tip portion of the plurality of securement members may not extend radially outward of the plurality of interconnected struts.

Abstract: An example occlusive implant is disclosed. The example occlusive implant includes an expandable framework configured to shift between a first configuration and a second expanded configuration, an occlusive member disposed along at least a portion of an outer surface of the expandable framework and a resilient member coupled to the occlusive member. Further, the resilient member is configured to keep the occlusive member taut against an outer surface of the expandable member in both the first configuration and the second configuration.

Abstract: An occlusive implant may include an expandable framework configured to shift between a collapsed configuration and an expanded configuration. The expandable framework includes a plurality of anchor members extending radially outward from the expandable framework in the expanded configuration, each anchor member including at least one base portion fixedly secured to the expandable framework and a plurality of anchor tips extending from each base portion. Each base portion extends longitudinally along the expandable framework. A method of making the occlusive implant may include forming the expandable framework, forming the plurality of anchor members, and fixedly attaching each base portion to the expandable framework such that each anchor member extends radially outward from the expandable framework in the expanded configuration and each base portion extends longitudinally along the expandable framework.

Abstract: An occlusion device for implantation in a left atrial appendage includes a proximal hub defining a recess configured to releasably connect with a delivery shaft, a frame connected to the proximal hub, a membrane coupled to and covering at least the proximal portion of the frame, the membrane comprising a material configured to block a passage of blood clots therethrough, and a plug configured to be received in the recess and remain in the recess after implantation.