Patents by Inventor Joshua McClure

Joshua McClure has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230304068
    Abstract: A method is provided for treating a recipient with a biological product obtained from at least one donor that may be the same as, or different from, the recipient. The method includes identifying a targeted level of gene expression of a first gene in a biological product to be transferred from at least one donor to a recipient; treating the at least one donor to achieve the targeted level of gene expression of the first gene in the biological product; and transferring the biological product from the at least one donor to the recipient.
    Type: Application
    Filed: May 31, 2023
    Publication date: September 28, 2023
    Inventors: ANNELISE E. BARRON, DAVID HAASE, JOSHUA MCCLURE
  • Patent number: 11697834
    Abstract: A method is provided for treating a recipient with a biological product obtained from at least one donor that may be the same as, or different from, the recipient. The method includes identifying a targeted level of gene expression of a first gene in a biological product to be transferred from at least one donor to a recipient; treating the at least one donor to achieve the targeted level of gene expression of the first gene in the biological product; and transferring the biological product from the at least one donor to the recipient.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: July 11, 2023
    Assignee: Maxwell Biosciences, Inc.
    Inventors: Annelise E. Barron, David Haase, Joshua McClure
  • Publication number: 20230173145
    Abstract: A contraceptive device is provided which includes a (preferably elastomeric) surface; and a lubricant applied to the surface. The lubricant includes (a) a lubricious medium, and (b) a pharmaceutically effective amount of a peptoid disposed in said lubricious medium. The antimicrobial peptoid may impart protection against some common sexually transmitted diseases, while also imparting spermicidal activity to the lubricious medium and contraceptive device.
    Type: Application
    Filed: December 18, 2020
    Publication date: June 8, 2023
    Inventors: ANNELISE E. BARRON, JOSHUA MCCLURE
  • Publication number: 20230063416
    Abstract: A polytherapy of orally available compounds is disclosed that synergistically modulates and induces the expression of the cathelicidin gene (CAMP), which encodes the host defense peptide LL-37. By providing a number of different CAMP-inducing compounds together at the same time, stronger gene induction is achieved than with just one or two compounds, because the mechanism of induction broadens. Induction also may vary in different pas of the body depending on which compounds are used, and at what levels. We show for the first time that the polytherapy can induce cathelicidin expression in the brain, which may help to treat or prevent Alzheimer's Disease Systemic cathelicidin gene induction may help treat numerous other conditions including Type 2 Diabetes/Metabolic Syndrome, or chronic bacterial, viral, or fungal infections associated with increased cancer risk or neurodegeneration.
    Type: Application
    Filed: October 11, 2022
    Publication date: March 2, 2023
    Applicants: Maxwell Biosciences, Inc., The Board of Trustees of the Leland Stanford Junior University
    Inventors: Annelise E. Barron, Andrew K. Evans, Jennifer S. Lin, Joshua McClure, Mehrdad Shamloo
  • Publication number: 20220401513
    Abstract: A method is provided for treating a subject for a viral infection. The method includes diagnosing the subject as having a viral infection, and administering a pharmaceutically effective amount of a pharmaceutical composition to the subject. The pharmaceutical composition includes a poly-N-substituted glycine compound of a formula AX-Y-Zn—B, wherein A is a terminal N-alkyl substituted glycine residue; n is an integer; B is selected from the group consisting of NH2, one and two N-substituted glycine residues, and wherein said one and two N-substituted glycine residues have N-substituents which are independently selected from natural ?-amino acid side chain moieties, isomers and carbon homologs thereof; X, Y and Z are independently selected from the group consisting of N-substituted glycine residues, wherein said N-substituents are independently selected from the group consisting of natural ?-amino acid side chain moieties, isomers and carbon homologs thereof, and proline residues.
    Type: Application
    Filed: September 30, 2020
    Publication date: December 22, 2022
    Inventors: ANNELISE E. BARRON, JOSHUA MCCLURE, GILL DIAMOND, NATALIA MOLCHANOVA
  • Publication number: 20200319209
    Abstract: A method is provided for treating a recipient with a biological product obtained from at least one donor that may be the same as, or different from, the recipient. The method includes identifying a targeted level of gene expression of a first gene in a biological product to be transferred from at least one donor to a recipient; treating the at least one donor to achieve the targeted level of gene expression of the first gene in the biological product; and transferring the biological product from the at least one donor to the recipient.
    Type: Application
    Filed: January 27, 2020
    Publication date: October 8, 2020
    Inventors: Annelise E. Barron, David Haase, Joshua McClure
  • Publication number: 20190015361
    Abstract: A polytherapy of orally available compounds is disclosed that synergistically modulates and induces the expression of the cathelicidin gene (CAMP), which encodes the host defense peptide LL-37. By providing a number of different CAMP-inducing compounds together at the same time, stronger gene induction is achieved than with just one or two compounds, because the mechanism of induction broadens. Induction also may vary in different parts of the body depending on which compounds are used, and at what levels. We show for the first time that the polytherapy can induce cathelicidin expression in the brain, which may help to treat or prevent Alzheimer's Disease. Systemic cathelicidin gene induction may help treat numerous other conditions including Type 2 Diabetes/Metabolic Syndrome, or chronic bacterial, viral, or fungal infections associated with increased cancer risk or neurodegeneration.
    Type: Application
    Filed: July 17, 2018
    Publication date: January 17, 2019
    Inventors: Annelise E. Barron, Andrew K. Evans, Jennifer S. Lin, Joshua McClure, Mehrdad Shamloo
  • Publication number: 20130254107
    Abstract: A system is provided for transferring funds between first and second participants to a face-to-face transaction. The system includes a software program, a first instance of which is installed on a first mobile communications device (401) associated with the first participant, and a second instance of which is on a second device (451) associated with the second participant. The program allows the second participant to receive an offer of payment (405) sent by the first participant from the first mobile communications device such that the offer is displayed on the second device. The offer indicates the amount of payment (409) associated with the offer, contains an image (407) of the first participant, and is accompanied by an acceptance indicia which, when selected by the second participant, results in the transfer of funds from an account associated with the first participant to an account associated with the second participant.
    Type: Application
    Filed: July 9, 2012
    Publication date: September 26, 2013
    Inventor: Joshua McClure