Abstract: Interfering nucleic acids and methods of their use in treat prostate cancers, such as aggressive prostate cancers. The nucleic acids may be, for example, short interfering RNA (siRNA), short hairpinRNA (shRNA), antisense RNA, antisense DNA, Chimeric Antisense DNA/RNA, and microRNA (miRNA) oligonucleotides. The oligonucleotide has a seed sequence that is complementary to a sequence of either a gene or an mRNA encoding an androgen receptor (AR) coregulator or a fragment thereof having AR coregulator activity. The nucleic acid compound may have a non-natural modification in the oligonucleotide, and/or an organic moiety conjugated to the oligonucleotide. The oligonucleotide has inhibitory activity against the expression or biological activity of the AR coregulator.

Abstract: A gripper has a body with a jaw support portion and powering portion. A powering assembly is positioned in the powering portion. A stationary jaw is secured to the jaw support portion. A movable jaw is pivotally secured to the jaw support portion about a pivot pin. A rod from the powering assembly connects in a slot on the movable jaw. The pivot pin is positioned on an opposite side of an axis of the rod on the clevis portion away from the stationary jaw. The non-clamping end of the movable jaw is incapable of extending below an end plane of the body of the stationary jaw side of the gripper.