Abstract: The invention taught herein provides a method, device and system for modulating or switching electromagnetic radiation by controlling a state of the radiation, such as a polarization state. Radiation is directed at a reflective or transmissive structure, such that the radiation is incident on the structure. The structure includes a property that can be dynamically switched between two configurations, one of which is asymmetric and is configured to modify the polarization characteristic of the radiation. The dynamically configurable structure can be combined with polarization components to achieve modulation. Embodiments suitable for mode-locking a laser and for cavity dumping a mode-locked laser are also disclosed.

Abstract: A method, apparatus and system for enhanced OCT measurement is described. The invention provides for using an OCT system with two or more optical sources with different wavelengths from each other to analyze tissue and measure scattering characteristics and absorption properties of a target. Embodiments include using multiple differential states: multiple wavelengths; multiple pressure wave environments; and multiple temperatures. Embodiments also include using temperature stabilization and speckle reduction by means of subjecting the target to one or more pressure waves.

Abstract: The invention provides a system and method for rapid validation of identity from tissue using registered two dimensional and optical coherence tomography (OCT) scan images. The preferred embodiment provides, for a human fingerprint, validation that the surface fingerprint matches the primary fingerprint. An alternate embodiment provides validation of “aliveness” by ascertaining blood flow. Various embodiments are taught.

Abstract: The invention teaches a method, apparatus and system for measuring bio-medical attributes of the eye, such as internal or intraocular pressure. The invention enables taking measurements of the relative location of various surfaces of components of the eye under different conditions. The invention provides for applying a pressure disturbance to the eye acoustically and, using non-invasive optical techniques to perform measurements of vibrations or measurements of the time varying relative location of one or more surfaces or structures in a manner correlated with the pressure disturbance.

Abstract: A micro phonic device capable of measuring very low frequency (sub 100 Hz) pressure waves includes an OCT measuring system that measures the position of one or more surfaces within a target. The device further processes the position measurements to generate a spectrum. In one application the generated spectrum is further processed to associate some signals with bio-sign parameters. Values of the bio-sign parameters are output.

Abstract: The invention provides for generating a set of signature signals that correspond to a range of depths within a target. These signature signals can include multiple individual reference signals and be can modified to compensate for specific characteristics of the target. In the preferred embodiment the members of the set of signature signals are correlated with data sets by phase rotating individual reference signals to determine maximum and minimum correlation and thereby enabling determination of the scattering characteristic of the target at each depth. Also a pilot signal is monitored to dynamically determine the phase relationship between individual reference signals and thereby avail of phase sensitive detection techniques to enhance SNR at deeper regions where multiple individual reference signals exist.

Abstract: The invention provides for generating a set of signature signals that correspond to a range of depths within a target. These signature signals can include multiple individual reference signals and be can modified to compensate for specific characteristics of the target. In the preferred embodiment the members of the set of signature signals are correlated with data sets by phase rotating individual reference signals to determine maximum and minimum correlation and thereby enabling determination of the scattering characteristic of the target at each depth. Also a pilot signal is monitored to dynamically determine the phase relationship between individual reference signals and thereby avail of phase sensitive detection techniques to enhance SNR at deeper regions where multiple individual reference signals exist.

Abstract: The invention teaches a field of light based method and system suitable for non-invasive target analysis, including in vivo analysis. A embodiment of the system comprises a field of light imaging device; an illuminating module consisting of a plurality of light sources that emit light radiation centered on multiple wavelengths; a partially reflective minor positioned to reflect radiation to the target from the illumination module, and from the target to the field of light imaging device; a display; a processing and control module coordinating target position, and the synchronous output of the illumination module with image capture by the field of light imaging device; and an output and storage device.

Abstract: The invention provides a method and system for non-invasive analysis. In particular the inventive system relates optical techniques involving infra-red, visible or ultra violet radiation for imaging and analyzing surface and sub-surface structure of tissue and components of the eye. Embodiments of the invention further include Optical Coherence Tomography (OCT) techniques for sub-surface imaging and analysis, and incorporate instruments such as ophthalmoscopes, fundus cameras, for non-invasive imaging and analysis.

Abstract: The invention taught herein provides a method, device and system for modulating or switching electromagnetic radiation by controlling a state of the radiation, such as a polarization state. Radiation is directed at a reflective or transmissive structure, such that the radiation is incident on the structure. The structure includes a property that can be dynamically switched between two configurations, one of which is asymmetric and is configured to modify the polarization characteristic of the radiation. The dynamically configurable structure can be combined with polarization components to achieve modulation. Embodiments suitable for mode-locking a laser and for cavity dumping a mode-locked laser are also disclosed.

Abstract: The invention teaches a field of light based method and system suitable for non-invasive target analysis, including in vivo analysis. A embodiment of the system comprises a field of light imaging device; an illuminating module consisting of a plurality of light sources that emit light radiation centered on multiple wavelengths; a partially reflective minor positioned to reflect radiation to the target from the illumination module, and from the target to the field of light imaging device; a display; a processing and control module coordinating target position, and the synchronous output of the illumination module with image capture by the field of light imaging device; and an output and storage device.

Abstract: The invention provides a method and system for non-invasive analysis. In particular the inventive system relates optical techniques involving infra-red, visible or ultra violet radiation for imaging and analyzing surface and sub-surface structure of tissue and components of the eye. Embodiments of the invention further include Optical Coherence Tomography (OCT) techniques for sub-surface imaging and analysis, and incorporate instruments such as ophthalmoscopes, fundus cameras, for non-invasive imaging and analysis.

Abstract: The invention provides for generating a set of signature signals that correspond to a range of depths within a target. These signature signals can include multiple individual reference signals and be can modified to compensate for specific characteristics of the target. In the preferred embodiment the members of the set of signature signals are correlated with data sets by phase rotating individual reference signals to determine maximum and minimum correlation and thereby enabling determination of the scattering characteristic of the target at each depth. Also a pilot signal is monitored to dynamically determine the phase relationship between individual reference signals and thereby avail of phase sensitive detection techniques to enhance SNR at deeper regions where multiple individual reference signals exist.

Abstract: The invention provides a system and method for using OCT to determine hydration and blood flow variation adjusted glucose measurement in a target of interest. For some target, including a target of a living human, the invention provides for the measurement of tissue components, for determination of hydration level and blood flow variations of target, for non-invasive determination of glucose in target, and for hydration-adjusted and blood flow compensated glucose measurement in target. In one embodiment, both the tissue components and glucose level are measured by OCT, and tables or indexes of hydration are used to determine hydration adjustment. In alternate embodiments, the hydration index may be partially or fully “individualized,” created from data collected from monitoring an individual or groups of individuals with pre-selected characteristics (ex. same gender, weight, age, ethnicity, diabetes stage, species, etc.).

Abstract: A non-invasive imaging and analysis system suitable for non-invasive imaging and analysis of defects or malignant aspects of targets such as cancer in skin or human tissue and suitable for measuring concentrations of specific components, such as blood glucose concentration includes an optical processing system which generates a probe and composite reference beam. The system also includes a means for applying the probe beam to the target to be analyzed and modulates at least some of the components of the composite reference beam such that signals with different frequency content are generated. The system combines a scattered portion of the probe beam and the composite beam interferometrically to simultaneously acquire information from multiple depths within a target. It further includes electronic control and processing systems.