Patents by Inventor Joshua O. Ojwaug

Joshua O. Ojwaug has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-viral guanosine-rich tetrad forming oligonucleotides
    Patent number: 6288042
    Abstract: Guanosine-rich oligonucleotides having sequences that favor the formation under physiological conditions of a stable four-stranded structure containing two stacked guanosine quartets (G4s) are disclosed. These oligonucleotides demonstrate enhanced nuclease resistance, cellular uptake and biological efficacy. Methods and composition for treating viral infection using these guanosine-rich oligonucleotides are also disclosed. Certain embodiments of the new oligonucleotides are 16-17 nucleotides long and contain at least one C-5 propynyl dU substitution. A method for designing anti-viral oligonucleotides is also disclosed.
    Type: Grant
    Filed: February 3, 1998
    Date of Patent: September 11, 2001
    Assignees: Aronex Pharmaceuticals, Inc., Baylor College of Medicine
    Inventors: Robert F. Rando, Joshua O. Ojwaug, Michael E. Hogan, Thomas L. Wallace, Paul A. Cossum