Abstract: A system and method for identifying a plurality of candidates for one or more clinical trials comprising receiving health related data associated with each of the plurality of candidates, applying a predictive risk model to the health related data and for generating and assigning a risk score to each of the plurality of candidates based on a selected condition and then ranking each of the plurality of candidates based on the risk score, and generating a similarity score for each of the candidates having an assigned risk score higher than the threshold risk score with a matching machine learning technique. The similarity score is indicative of a similarity between each of the plurality of candidates and one or more participants in the one or more clinical trials.

Abstract: A wheelbarrow assembly is disclosed with a wheelbarrow tray, a wheel to connect to the tray for rotation relative to the tray, for transportation of the tray upon an underlying support surface and a pair of handle assemblies. Each handle assembly is provided with a first unitarily formed handle portion with a distal end, an intermediate region, and a proximal end. The proximal end has a cross-section that is reduced relative to a cross-section of the intermediate region. The second handle portion is provided with a distal end and a proximal end; the proximal end having a cross-section that is sized to receive the first handle distal end cross-section therein to assemble the second handle portion to the first handle portion.

Abstract: There are disclosed therapies and preventions of prion protein complex infections. The transcription of the amyloid precursor protein gene and PrP gene and the RNA transcript are the rate-limiting steps and are most susceptible for blockage and control of the process of amyloid protein formation and PrPsc formation. Thus, therapies and prevention regimes for prion protein complex infections interrupt this process at the level of DNA transcription to RNA, RNA transport to the mitochondrion for protein synthesis and deposition in the cerebral cortex neurons.

Abstract: A design for a universal telescoping swing gate can be sized to obscure a wide range of openings while accommodating a multitude of installation options to make the gate versatile under many conditions. The swing gate can have a frame with a pivot member rotatable about a mounting seat between an open configuration and a closed configuration. The frame can have first and second telescoping members adjustable along an extension axis between a collapsed state and a fully extended state for changing the frame length so the gate can be quickly furnished to different sized openings. The gate can be spring loaded to bias the frame to a nominally closed position to reduce the chance for human error among workers. The gate can also be sized to have the structural rigidity to comply with OSHA requirements for handrails and guardrails around a walking-working surface.

Abstract: A tool handle coupling assembly is provided with a coupler with an opposed pair of receptacles. A pair of bushings are each sized to receive a portion of a handle therein and are each sized to be installed into one of the pair of receptacles.

Abstract: There are disclosed therapies and preventions of prion protein complex infections. The transcription of the amyloid precursor protein gene and PrP gene and the RNA transcript are the rate-limiting steps and are most susceptible for blockage and control of the process of amyloid protein formation and PrPsc formation. Thus, therapies and prevention regimes for prion protein complex infections interrupt this process at the level of DNA transcription to RNA, RNA transport to the mitochondrion for protein synthesis and deposition in the cerebral cortex neurons.

Abstract: Double reflector electromagnetic systems implementable in miniaturized satellites and other applications for compact, light weight, and broadband antennas. The disclosed methods and devices include primary and secondary reflectors, where the secondary reflector is held in the aperture plane of the primary reflector to minimize required space. A specific Cassegrain configuration is also described.

Abstract: A design for a universal telescoping swing gate can be sized to obscure a wide range of openings while accommodating a multitude of installation options to make the gate versatile under many conditions. The swing gate can have a frame with a pivot member rotatable about a mounting seat between an open configuration and a closed configuration. The frame can have first and second telescoping members adjustable along an extension axis between a collapsed state and a fully extended state for changing the frame length so the gate can be quickly furnished to different sized openings. The gate can be spring loaded to bias the frame to a nominally closed position to reduce the chance for human error among workers. The gate can also be sized to have the structural rigidity to comply with OSHA requirements for handrails and guardrails around a walking-working surface.

Abstract: There are disclosed therapies and preventions of prion protein complex infections. The transcription of the amyloid precursor protein gene and PrP gene and the RNA transcript are the rate-limiting steps and are most susceptible for blockage and control of the process of amyloid protein formation and PrPsc formation. Thus, therapies and prevention regimes for prion protein complex infections interrupt this process at the level of DNA transcription to RNA, RNA transport to the mitochondrion for protein synthesis and deposition in the cerebral cortex neurons.

Abstract: Provided are photoacoustic imaging contrast agents that include at least one radiation-absorbing component comprising a copper-complexed and/or manganese-complexed chlorin and/or bacteriochlorin and/or a derivative thereof, or a combination thereof. Also provided are methods for using the disclosed photoacoustic imaging contrast agents either singly or in combination for generating an image of a volume, optionally a subject or a body part, cell, tissue, or organ thereof. Further provided are compositions and methods for multiplex photoacoustic imaging of a volume, optionally a subject or a body part, cell, tissue, or organ thereof using photoacoustic imaging contrast agents that include a plurality of the presently disclosed copper-complexed and/or manganese-complexed chlorins and/or bacteriochlorins and/or derivatives thereof simultaneously.

Abstract: A test and measurement device includes an input configured to receive an analog signal from a Device Under Test (DUT), an Analog to Digital Converter (ADC) coupled to the input and structured to convert the analog signal to a digital signal, a receiver implemented in a first Field Programmable Gate Array (FPGA) and structured to accept the digital signal and perform signal analysis on the digital signal, a transmitter implemented in a second FPGA and structured to generate a digital output signal, and a Digital to Analog Converter (DAC) coupled to the transmitter and structured to convert the digital output signal from the transmitter to an analog signal, and structured to send the analog signal to the DUT. The receiver and the transmitter are coupled together by a high speed data link over which data about the current testing environment may be shared.

Abstract: The present disclosure describes techniques concerning a fan assembly. The fan assembly may include a fan, having multiple blades to rotate about an axis, and a housing in which the fan is disposed. Additionally, the fan assembly may include an air inlet formed in a wall of the housing that is transverse to the axis. The air inlet may define an orifice and includes multiple air guides that each extend into the housing from a perimeter of the air inlet.

Abstract: The present invention provides a single-piece printed circuit board heat sink and encapsulation device configured to efficiently dissipate heat away from the printed circuit board, along with associated methodology for dispersing heat from a printed circuit board.

Abstract: There are disclosed therapies and preventions of prion protein complex infections. The transcription of the amyloid precursor protein gene and PrP gene and the RNA transcript are the rate-limiting steps and are most susceptible for blockage and control of the process of amyloid protein formation and PrPsc formation. Thus, therapies and prevention regimes for prion protein complex infections interrupt this process at the level of DNA transcription to RNA, RNA transport to the mitochondrion for protein synthesis and deposition in the cerebral cortex neurons.

Abstract: The invention provides certain azetidinyloxyphenylpyrrolidine compounds, particularly compounds of formula I, and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I to treat overactive bladder.

Abstract: Double reflector electromagnetic systems implementable in miniaturized satellites and other applications for compact, light weight, and broadband antennas. The disclosed methods and devices include primary and secondary reflectors, where the secondary reflector is held in the aperture plane of the primary reflector to minimize required space. A specific Cassegrain configuration is also described.

Abstract: There are disclosed therapies and preventions of prion protein complex infections. The transcription of the amyloid precursor protein gene and PrP gene and the RNA transcript are the rate-limiting steps and are most susceptible for blockage and control of the process of amyloid protein formation and PrPsc formation. Thus, therapies and prevention regimes for prion protein complex infections interrupt this process at the level of DNA transcription to RNA, RNA transport to the mitochondrion for protein synthesis and deposition in the cerebral cortex neurons.

Abstract: The present disclosure describes techniques concerning a fan assembly. The fan assembly may include a fan, having multiple blades to rotate about an axis, and a housing in which the fan is disposed. Additionally, the fan assembly may include an air inlet formed in a wall of the housing that is transverse to the axis. The air inlet may define an orifice and includes multiple air guides that each extend into the housing from a perimeter of the air inlet.