Abstract: This invention provides an antisense oligonucleotide or analog thereof comprising 10 or more contiguous bases or base analogs from the sequence of bases of sequence A, B, C, D, E, F, G, H, I, J, K, L, or M of FIG. 1. This invention also provides the above-described antisense oligonucleotides, wherein the nucleotide sequence comprises nucleotide sequence A, A?, B, C, C?, D, E, E, E?, F, G, G?, H, H?, I, I?, J, K, K?, L, L?, M, or M? of FIGS. 2A and 2B. This invention also provides the above-described antisense oligonucleotides, wherein the oligonucleotide is encapsulated in a liposome or nanoparticle. This invention also provides the above-described antisense oligonucleotides, wherein the phosphate backbone comprises phosphorothioate bonds. In addition, this invention provides a method of treating cancer, comprising introducing into a tumor cell an effective amount of the the above-described antisense oligonucleotide, thereby reducing the levels of bcl-xL protein produced and treating cancer.

Abstract: The present invention relates generally to the fields of chemistry and molecular biology. More particularly, it concerns the use of compounds to treat viral infection. In a preferred embodiment, 2-amino-8-(?-D-ribofuranosyl) imidazo [1,2-a]-s-triazine-4-one may be used to treat infection by viruses of the Flaviviridae family.

Abstract: This invention relates to the field of drug discovery. Specifically, it describes a method (“Inverted Drug Screening” or “IDS™”) of identifying therapeutics from ethnobotanical (EB) preparations by repeatedly fractionating and testing fractions from EB sources. One aspect of the invention relates to quinic acid derivatives (e.g., derivatives of 3,5-dicaffeoyl quinic acid) for the treatment of respiratory syncytial virus (RSV) infection.

Abstract: This invention provides an antisense oligonucleotide or analog thereof comprising 10 or more contiguous bases or base analogs from the sequence of bases of sequence A, B, C, D, E, F, G, H, I, J, K, L, or M of FIG. 1. This invention also provides the above-described antisense oligonucleotides, wherein the nucleotide sequence comprises nucleotide sequence A, A′, B, C, C′, D, E, E, E′, F, G, G′, H, H′, I, I′, J, K, K′, L, L′, M, or M′ of FIGS. 2A and 2B. This invention also provides the above-described antisense oligonucleotides, wherein the oligonucleotide is encapsulated in a liposome or nanoparticle. This invention also provides the above-described antisense oligonucleotides, wherein the phosphate backbone comprises phosphorothioate bonds.