Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Improved support structures and systems are disclosed for installing tablet devices, display screens, flat screen monitors, or medical devices within a wide variety of environments. A core arm extends from a rear end, toward a front end, in which the rear end is configured to be pivotably mounted either directly to a mount structure, or to an extension arm that in turn is mounted to a mount structure. The front end is configured to be pivotably mounted to a front-end panel mount structure. The structures and systems can be configured for light or heavy configurations, with or without the use of an extension arm, and can provide fully concealed cable routing, in which one or more cables are readily accessible, via snap fit covers, for easy installation and maintenance, which can provide a clean structure that can readily be serviced and cleaned as desired.

Abstract: A data modeling and analytics platform augments and annotates content captured from a user's online interactions and other documents. The data modeling and analytics platform is performed within a machine learning and artificial intelligence-based processing environment that enables observability, explainability, and data analytics for dynamic information discovery over time within a user library that includes files representing the online interactions and documents containing information of user interest.

Abstract: Structures and systems are disclosed for supporting tablets or displays. A core arm that is configured to have a range of rotation based on angle length of a track or tunnel, an angle length of a joint rotation stop structure, and an angle length of a floating stop key. The core extends from a rear end to a front end of the structure. The core arm can also include a floating stop key that is movable with the track or tunnel of the core arm structure. The structures and systems can thus be readily configured for light or heavy configurations, with or without the use of an extension arm, and can conceal cable routing, which is accessible, via snap fit covers, for easy installation and maintenance.

Abstract: Systems and methods of the present disclosure enable variable and dynamic feedback to electronic activities by receiving event data and utilizing a feedback machine learning model to predict an average feedback attribute and an average feedback variability attribute based on the event data. A feedback data entry is added to a user profile to store the average feedback attribute and the average feedback variability attribute. A new event and a new event attribute are received for the user profile, and a feedback probability distribution for the new event is generated based on the new event attribute, the average feedback attribute, and the average feedback variability attribute. A new event feedback is generated for the new event based on a random selection from the feedback probability distribution and is output to a computing device associated with the user profile.

Abstract: Thermal management techniques include: transporting a refrigerant fluid from a receiver to an inlet of a flash tank that has a vapor-side outlet and liquid-side outlet such that a liquid phase of the refrigerant fluid moves to a bottom of the flash tank and outputs from the liquid-side outlet; forming a solid-vapor state from the liquid phase by expanding the liquid phase with an expansion valve to a first pressure that is less than a triple point pressure to form a solid-vapor mixture of the refrigerant fluid; extracting heat from a heat load with an evaporator that receives the solid-vapor mixture of the refrigerant fluid and sublimates the solid state of the solid-vapor mixture of the refrigerant fluid directly into a vapor phase of the refrigerant fluid; and discharging, from an exhaust line, the vapor phase to an ambient environment without returning the vapor phase to the receiver.

Abstract: A thermal management system includes an open-circuit refrigeration system including a cooling system configured to supply a cooling medium. The open-circuit refrigeration system includes a receiver having a receiver outlet, the receiver configurable to store a refrigerant fluid, the receiver configured to receive the cooling medium from the cooling system, an evaporator coupled to the receiver outlet, the evaporator configurable to receive liquid refrigerant fluid from the receiver outlet and to extract heat from a heat load when the heat load contacts or is proximate to the evaporator a control device configurable to control a temperature of the heat load and an exhaust line, with the receiver, the evaporator, and the exhaust line coupled to form an open-circuit refrigerant fluid flow path.

Abstract: Thermal management systems include an open circuit refrigeration system featuring a receiver configurable to store a refrigerant fluid, an evaporator configurable to extract heat from a heat load when the heat load contacts the evaporator, and an exhaust line, where the receiver, the evaporator, and the exhaust line are connected to form a refrigerant fluid flow path, and a first control device configurable to control a vapor quality of the refrigerant fluid at an outlet of the evaporator along the refrigerant fluid flow path.

Abstract: A thermal management system that includes an open-circuit refrigeration system having an open-circuit refrigerant fluid flow path is described. The open-circuit refrigeration system includes a receiver configured to store a refrigerant fluid, an evaporator configured to receive the refrigerant fluid at a evaporator inlet and to extract heat from a heat load that contacts the evaporator, and provide refrigerant vapor at a evaporator outlet. The open-circuit refrigeration system also includes a vapor pump device having a vapor pump inlet that receives the refrigerant vapor and having a vapor pump outlet that outputs compressed refrigerant vapor to an exhaust line coupled to the vapor pump outlet, with the receiver, the evaporator, the vapor pump device, and the exhaust line connected in the open-circuit refrigerant fluid flow path.

Abstract: Methods and systems are described for improvements to authentication processes. For example, conventional systems may rely on password authentication or contact-based alternative authentication techniques that are impractical or infeasible in sensitive medical environments, during pandemics, or fail meet the health and safety needs of an increasingly health-conscious public. In contrast, the described solutions provide an improvement over conventional authentication systems and methods by enabling user authentication via contactless physiological biometric authentication processes, behavioral authentication processes, and passive data authentication processes, that do not require a user to remove personal protective equipment.

Abstract: A thermal management system includes an open-circuit refrigeration system having an open-circuit refrigerant fluid flow path. The open-circuit refrigeration system includes a receiver configured to store a refrigerant fluid, an evaporator configured to receive the refrigerant fluid at an evaporator inlet and to extract heat from a heat load that contacts the evaporator, and provide refrigerant vapor at an evaporator outlet. The open-circuit refrigeration system also includes a vapor pump device having a vapor pump inlet that receives the refrigerant vapor and having a vapor pump outlet that outputs compressed refrigerant vapor to an exhaust line coupled to the vapor pump outlet, with the receiver, the evaporator, the vapor pump device, and the exhaust line connected in the open-circuit refrigerant fluid flow path.

Abstract: Disclosed herein are system, method, and computer program product embodiments for training and deploying a machine learning model to generate an assessment of risks and mitigations in response to a novel initiative request. After generating labeled data from a corpus of prior risk assessments, a machine learning model may be trained to programmatically generate a risk assessment in response to a novel initiative request. A risk auditor may subsequently review the risk assessment generated using the machine learning model to provide various feedback reflecting the accuracy of the risks and mitigations. The machine learning model may then be retrained based on the feedback provided by the risk auditor to provide more accurate risks and mitigations in response to future initiatives.

Abstract: Disclosed herein are system, method, and computer program product embodiments for training and deploying a machine learning model to generate an assessment of risks and mitigations in response to a novel initiative request. After generating labeled data from a corpus of prior risk assessments, a machine learning model may be trained to programmatically generate a risk assessment in response to a novel initiative request. The system may provide for centralized control over the creation, review, and approval of initiative requests. The system may further analyze consumer-facing applications deployed by an organization and train the machine learning model to algorithmically determine consumer-facing applications potentially affected by an initiative request.

Abstract: A thermal management system includes a refrigerant receiver configured to store a refrigerant fluid, a closed-circuit refrigeration system having a closed-circuit fluid path with the refrigerant receiver, and with the closed-circuit refrigeration system configured to receive refrigerant from the refrigerant receiver through the closed-circuit fluid path, an open-circuit refrigeration system having an open-circuit fluid path, and with the refrigerant receiver disposed in the open-circuit fluid path, with the open-circuit refrigeration system configured to receive refrigerant through the open-circuit fluid path, and discharge refrigerant fluid through an exhaust line, and an evaporator arrangement configured to receive the refrigerant and to extract heat from at least one heat load, the evaporator arrangement having an inlet and an outlet, with the evaporator disposed in a common portion of the closed-circuit fluid path and the open-circuit fluid path.

Abstract: A thermal management system includes a closed-circuit refrigeration system that includes a vapor cycle system (VCS) and a liquid pumping system (LPS). The VCS includes a receiver that stores a refrigerant fluid and a liquid separator. The vapor cycle system is configured to operate in one or more operational modes including at least one of a TES cooling mode, a heat load cooling mode, or a pump-down mode. The LPS includes a thermal energy storage (TES) that stores a phase change material (PCM) and a pump fluidly coupled to at least one evaporator. The evaporator is configured to extract heat from a heat load that is in thermal conductive or convective contact to the evaporator to transfer heat to the refrigerant fluid and provide the refrigerant fluid from an evaporator outlet to the TES.

Abstract: A thermal management system that includes an open-circuit refrigeration system having an open-circuit refrigerant fluid flow path is described. The open-circuit refrigeration system includes a receiver configured to store a refrigerant fluid, an evaporator configured to receive the refrigerant fluid at a evaporator inlet and to extract heat from a heat load that contacts the evaporator, and provide refrigerant vapor at a evaporator outlet. The open-circuit refrigeration system also includes a vapor pump device having a vapor pump inlet that receives the refrigerant vapor and having a vapor pump outlet that outputs compressed refrigerant vapor to an exhaust line coupled to the vapor pump outlet, with the receiver, the evaporator, the vapor pump device, and the exhaust line connected in the open-circuit refrigerant fluid flow path.

Abstract: Disclosed is a mechanism to exhaust refrigerant vapor resulting from operation of a thermal management system that is used to cool a thermal load by a vehicle, such as an airborne vehicle. The thermal management system includes an open circuit refrigeration system featuring a receiver configured to store a liquid refrigerant fluid, an evaporator configured to extract heat from the thermal load that contacts the evaporator, and an exhaust line, where the receiver, the evaporator, and the exhaust line are connected to provide an open refrigerant fluid flow path. Other implementations of open circuit refrigeration systems include the use of a gas receiver, a pump and an ejector are also described, as are other mechanisms to exhaust refrigerant vapor resulting from operation of the thermal management system.

Abstract: A directed energy system includes a gimbal assembly that includes a turret configured to rotate about a first axis, and a directed energy head coupled to the turret and configured to rotate about a second axis that is orthogonal to the first axis. The system further includes an optical fiber spooling ring comprised of a fiber cable at least partially threaded through the gimbal assembly and including a plurality of optical fibers configured to transmit optical energy. The optical fiber spooling ring includes a plurality of 360 degree rotations of the fiber cable.

Abstract: A thermal management system includes an integrated open-circuit refrigeration system and closed-circuit heat pump system. The thermal management system includes a receiver having a first receiver port and a second receiver port, the receiver configured to store a refrigerant fluid, an evaporator having a first evaporator port and a second evaporator port, the heat pump circuit having a closed-circuit fluid path with the receiver and the evaporator and an open-circuit refrigeration system configured to receive refrigerant from the receiver, with the open-circuit refrigeration system having an open-circuit fluid path that includes the receiver and the evaporator.

Abstract: Aspects described herein may allow for detecting fraudulent transaction requests using light sensors on smartcards. A computing device may receive, from a terminal, a request to approve a transaction. The request may comprise a timestamp corresponding to a time when the transaction was requested, a transaction type associated with the transaction, and an identification of a card associated with the transaction. The computing device may also receive, from one or more light sensors associated with the card, light data. The light data indicates an amount of ambient light during a time period when the transaction was requested. The computing device may determine, based on the transaction type, a model of expected ambient light. If the light data corresponds to the model, the computing device may send, based on the determination that the light data corresponds to the model, an approval of the request.