Patents by Inventor Joshua R. Bliesath

Joshua R. Bliesath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variants of C-type natriuretic peptides
    Patent number: 8377884
    Abstract: The present invention provides variants of C-type natriuretic peptide (CNP) comprising one or more deletions; additions of and/or substitutions with natural amino acids, unnatural amino acids and/or peptidomimetics (including peptide bond isosteres); amino acid extensions; and/or other chemical moieties such as, e.g., poly(ethylene glycol) and hydrophobic acids. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders such as, e.g., skeletal dysplasias and achondroplasia, and vascular smooth muscle disorders such as, e.g., restenosis and arteriosclerosis.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: February 19, 2013
    Assignee: Biomarin Pharmaceutical Inc.
    Inventors: Daniel J. Wendt, Mika Aoyagi-Scharber, Sean Bell, Dong Wei, Joshua R. Bliesath, Emil D. Kakkis
  • Biomarkers for predicting the sensitivity and response of protein kinase CK2-mediated diseases to CK2 Inhibitors
    Publication number: 20110212845
    Abstract: Disclosed are biomarkers for determining the sensitivity of protein kinase CK2-mediated diseases, such as proliferative and/or inflammatory disorders, to treatment with CK2 inhibitors. These biomarkers can be used to predict or select subjects likely to be responsive to treatment with a CK2 inhibitor, and to treat or monitor subjects undergoing treatment with a CK2 inhibitor.
    Type: Application
    Filed: October 4, 2010
    Publication date: September 1, 2011
    Inventors: Denis DRYGIN, Sean E. O'BRIEN, Kenna L. ANDERES, Daniel VON HOFF, John K.C. LIM, Claire S. PADGETT, Joshua R. BLIESATH, Caroline B. HO, William G. Rice
  • Variants of C-Type Natriuretic Peptides
    Publication number: 20100331256
    Abstract: The present invention provides variants of C-type natriuretic peptide (CNP) comprising one or more deletions; additions of and/or substitutions with natural amino acids, unnatural amino acids and/or peptidomimetics (including peptide bond isosteres); amino acid extensions; and/or other chemical moieties such as, e.g., poly(ethylene glycol) and hydrophobic acids. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders such as, e.g., skeletal dysplasias and achondroplasia, and vascular smooth muscle disorders such as, e.g., restenosis and arteriosclerosis.
    Type: Application
    Filed: November 21, 2008
    Publication date: December 30, 2010
    Inventors: Dan J. Wendt, Mika Aoyagi-Scharber, Sean Bell, Dong Wei, Joshua R. Bliesath, Emil D. Kakkis
  • TREATMENT OF NEOPLASTIC DISORDERS USING COMBINATION THERAPIES
    Publication number: 20100173013
    Abstract: The present application is generally directed to compounds, compositions and methods of combination therapy for the treatment of neoplastic disorders.
    Type: Application
    Filed: January 7, 2010
    Publication date: July 8, 2010
    Inventors: Denis Drygin, Kenna Anderes, Caroline B. Ho, Joshua R. Bliesath, Christopher B. Proffitt, Sean O'Brien, William G. Rice