Abstract: Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.

Abstract: A mobility device configurable in a first walk configuration and a second stair-climb configuration, including a frame with movable front leg portions, a leg-actuation system connected to the front leg portions and a safety-control device mounted to the frame. The safety-control device includes a configuration selector, and a lever connected to the leg-actuation system and configured to actuate the cable actuation system so as to cause the first and second movable leg portions to move from a first position to a second position. The lever remains locked in a first lever position such that the lever cannot be moved unless the configuration selector is in a depressed position, thereby preventing inadvertent movement of the leg portion.

Abstract: A tool is provided that includes unitary plate that includes a blade portion and a tang portion. The blade portion can include an edge. The tang portion can include a positioning hole, a first hole, a slot, a second hole, a rivet hole, and one or more teeth (also referred to as one or more barbs) on a side of the tang portion. The tool can further include a hilt member which includes a through passage, a tab, and a notch. The tool includes an overlay on a body to create a handle for gripping the tool. The tool further includes a hammerhead cap on an end of the body, the hammerhead cap is coupled to the handle with a rivet through the rivet hole.

Abstract: A continuous (multi-)analyte sensor device is provided, comprising a (multi-)analyte sensor operably coupled to a signal transducer, the (multi-)analyte sensor comprising at least one membrane, the least one membrane comprising a least one first transducing element, and at least one of a mediator and/or a regenerative cofactor.

Abstract: This application relates to a building energy analysis and management system for measurement and verification of building performance. The system can analyze, optimize, manage, maintain, trouble shoot, and/or modify building systems, such as HVAC systems, in connection with the building energy usage. Measurements may be gathered for one or more HVAC units coupled to pressure independent valves, and sent to one or more Surge Panels that pass data to remote analysis servers, which can receive other system or external data. The analysis servers compare measurements to predicted values and can standardize the predicted values to account for external conditions. The comparison can result in difference values used to generate probable causes and optimization recommendations. The system outputs reports or other data display using a graphical user interface that can be adjusted for an anticipated user.

Abstract: Fault detection and diagnostics for a microneedle array based continuous analyte monitoring device are provided. The electrochemical sensors, including the electrodes of the analyte monitoring device configured for measuring one or more target analytes, may experience various faults during use of the analyte monitoring device. By modeling the sensors as an electrical network, measurements of the electrical network may be correlated with operational parameters of the sensor. The voltage at the counter electrode provides an indication of the resistance or impedance between the working electrode and the counter electrode and is used to identify the occurrence of faults occurring at the continuous analyte monitoring device.

Abstract: Devices and methods for measuring a concentration of a target analyte in a biological fluid in vivo are provided herein. In some examples, a device includes an indwelling sensor and sensor electronics. The sensor may include a substrate; a first electrode disposed on the substrate; an ionophore disposed on the substrate to selectively transport the target ion to or within the first electrode; and a second electrode disposed on the substrate. The sensor electronics is configured to generate a signal corresponding to an electromotive force which is at least partially based on a potential difference that is generated between the first electrode and the second electrode responsive to the ionophore transporting the target ion to the first electrode.

Abstract: Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.

Abstract: Aspects of the current subject matter are directed to a sensor assembly of an analyte monitoring device including one or more microneedle arrays. Aspects are directed to components and architecture of a sensor assembly to implement power and processing aspects of a microneedle array-based continuous analyte monitoring device for the detection and measuring of an analyte. A source of a power-on event is determined, and the analyte monitoring device is transitioned to a mode that corresponds to the determined source. When a power-on event is determined to be a valid power-on event, the analyte monitoring device is transition to a mode that corresponds to a type of the valid power-on event.

Abstract: Fault detection and diagnostics for a microneedle array based continuous analyte monitoring device are provided. The electrochemical sensors, including the electrodes of the analyte monitoring device configured for measuring one or more target analytes, may experience various faults during use of the analyte monitoring device. By modeling the sensors as an electrical network, measurements of the electrical network may be correlated with operational parameters of the sensor. The voltage at the counter electrode provides an indication of the resistance or impedance between the working electrode and the counter electrode and is used to identify the occurrence of faults occurring at the continuous analyte monitoring device.

Abstract: In some embodiments, the present disclosure describes a method that includes at least: receiving, by a processor, audience data identifying candidate audience for a website content; generating a plurality of audience groups based on the audience data; receiving user identifying data of a user; generating personalized online content for the user; tagging the personalized online content with a plurality of dynamic tokens to form trackable personalized online content; transmitting instructions to display the trackable personalized online content on a screen of a computing device; receiving user activity tracking data; training a machine learning algorithm, based on the user activity tracking data, to obtain a trained machine learning content recommendation engine; and utilizing the trained machine learning content recommendation engine to identify updated trackable personalized online content based on a plurality of markups to the trackable personalized online content.

Abstract: Disclosed herein are systems and methods for a continuous analyte monitoring system for measuring a concentration of a first analyte and concentration of a second analyte in a host. One such system utilizes a working electrode and a reference electrode to measure glucose concentration and oxygen concentration in bodily fluid of a host. The system includes a sensor control circuit that applies a first bias condition to the sensor to measure a first signal generated by the sensor indicative of a concentration of the first analyte. The sensor control circuit also applies a second bias condition to the sensor to measure a second signal generated by the sensor indicative of a concentration of a second analyte at the host.

Abstract: Described herein are variations of a cortisol monitoring system, including a cortisol monitoring device. For example, a cortisol monitoring device may include a skin-penetrating microneedle array for use in measuring cortisol, such as in a continuous manner. The microneedle array may include, for example, at least one microneedle comprising a working electrode comprising a cortisol-sensing aptamer that selectively and reversibly binds to cortisol. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.

Abstract: A method and apparatus for filter testing for use within an air handling system. The air handling system may include one or more scan assemblies. The scan assembly may include a track system using one or more magnetic arrays.

Abstract: Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.

Abstract: A portable medical triage kit and interactive application that leads a user through a medically acceptable triage protocol for treating medical emergencies. The interactive application leads the user to treat major life threats of all nearby victims before treating minor threats of anyone.

Abstract: A method and device to impart the ability to selectively quantify chemical/biochemical analytes occupying physiological fluids via an automated process that allow the precise and spatially-defined simultaneous deposition of a thin-film of polymer containing an immobilized biorecognition element dispersed therein. A tissue penetrating electrochemical sensor comprises at least one working electrode and at least one of a reference electrode and a counter electrode.

Abstract: Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.