Abstract: A precision medicine system for patient management and rare disease identification can include an interface and a global data lake. The interface can be configured to search a plurality of search databases including medical data related to diagnosis or treatment plans. The global data lake can be configured to include a plurality of patient data lakes each storing patient data of at least one patient. The precision medicine system can further include a processor and a memory configured to label the patient data using medical ontologies and selectively produce relevant medical data from the search databases via the interface. The patient data can then be supplemented with the medical data. Embodiments enable clinicians to provide specialized, up to date diagnosis and treatment plants to patients by providing the clinicians with medical advancements specific to their patient.