Patents by Inventor Joshua Rokach

Joshua Rokach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibition of indoleamine-N-methyl transferase by 2-iminopyridines
    Patent number: 4105769
    Abstract: A method of inhibiting indoleamine-N-methyl transferase comprises the administration to a host of a therapeutically effective amount of 1-alkyl-2-iminopyrrolidines or 1-alkyl-2-iminopyridines or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: January 24, 1977
    Date of Patent: August 8, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Clarence S. Rooney, Joshua Rokach, Edward J. Cragoe, Jr.
  • 2-R-Substituted-1,2,5-thiadiazole-3-one antimicrobials
    Patent number: 4094986
    Abstract: 2-R-substituted-1,2,5-thiadiazole-3-ones have broad spectrum antibacterial and antifungal activity. They are especially useful in agriculture to protect plants against diseases such as leaf, stem, and fruit spotting, internal discoloration and decay of fruits and vegetables. These compounds are particularly active against diseases caused by the genera Pseudomonas, Xanthomonas, Erwinia, and Corynebacterium.
    Type: Grant
    Filed: July 5, 1977
    Date of Patent: June 13, 1978
    Assignee: M. S. & D. (I.A.) Corp.
    Inventors: Joshua Rokach, Grant W. Reader
  • 2-Imino-3-aminothiazolidines and indoleamine-N-methyltransferase inhibition
    Patent number: 4091105
    Abstract: 2-Imino-3-aminothiazolidines are inhibitors of indoleamine-N-methyl transferase in vivo.
    Type: Grant
    Filed: August 12, 1977
    Date of Patent: May 23, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Joshua Rokach, Clarence S. Rooney, Grant W. Reader, Edward J. Cragoe, Jr.
  • Pyrrolo[2,1-b][3]benzazepines
    Patent number: 4075225
    Abstract: 6,11-Dihydro-5H-Pyrrolo[2,1-b][3]benzazepin-11-one and derivatives thereof are generally prepared by Friedel-Crafts ring closure of a N-phenethylpyrrole-2-carboxylic acid halide. They are useful intermediates in the synthesis of skeletal muscle relaxants and tranquilizers such as 11-(3-dimethylaminopropylidene)-6,11-dihydro-5H-pyrrolo[2,1-b][3]benzazepi ne.
    Type: Grant
    Filed: June 29, 1976
    Date of Patent: February 21, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Joshua Rokach, Joseph G. Atkinson, Clarence S. Rooney
  • Dihydro- and tetrahydro- iminothiazines
    Patent number: 4054652
    Abstract: Dihydro- and tetrahydro-iminothiazines are inhibitors of indoleamine-N-methyl transferase in vivo.
    Type: Grant
    Filed: June 15, 1976
    Date of Patent: October 18, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Clarence S. Rooney, Joshua Rokach, Edward J. Cragoe, Jr.
  • Method of treatment with 2-iminothiazolidines and thiazolines
    Patent number: 4029803
    Abstract: A method of inhibiting indoleamine-N-methyl transferase comprises the administration to a host of a therapeutically effective amount of a 3-hydrocarbyl-2-imino-thiazolidine or thiazoline or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 3, 1976
    Date of Patent: June 14, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Norman R. Hunter, Clarence S. Rooney, Joshua Rokach, Edward J. Cragoe, Jr.
  • Imidazothiazines
    Patent number: 4025625
    Abstract: Dihydro- and tetrahydro-imidazothiazines are inhibitors of indoleamine-N-methyl transferase in vivo.
    Type: Grant
    Filed: June 15, 1976
    Date of Patent: May 24, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Clarence S. Rooney, Joshua Rokach, Edward J. Cragoe, Jr.
  • 2-Aminomethyl-5-hydroxy-4H-pyran-4-one and derivatives thereof
    Patent number: 3968236
    Abstract: The 2-aminomethyl-5-hydroxy-4H-pyran-4-ones of the present invention are disclosed to have pharmaceutical utility as skeletal muscle relaxants. Also disclosed are processes for the preparation of such pyranones; pharmaceutical compositions comprising such compounds; and method of treatment comprising administering such compounds and compositions when a muscle relaxant effect is indicated.
    Type: Grant
    Filed: January 22, 1975
    Date of Patent: July 6, 1976
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, Joshua Rokach, Clarence S. Rooney