Patents by Inventor Joshua S. Boger

Joshua S. Boger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Renin inhibitors containing 2-substituted statine
    Patent number: 4663310
    Abstract: Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.
    Type: Grant
    Filed: April 4, 1984
    Date of Patent: May 5, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Mark G. Bock, Joshua S. Boger, Stephen F. Brady, Daniel F. Veber
  • Renin inhibitors containing peptide isosteres
    Patent number: 4661473
    Abstract: Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.
    Type: Grant
    Filed: March 27, 1984
    Date of Patent: April 28, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Joshua S. Boger, Mark G. Bock
  • Renin inhibitory peptides having improved solubility
    Patent number: 4636491
    Abstract: Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.
    Type: Grant
    Filed: March 27, 1984
    Date of Patent: January 13, 1987
    Assignee: Merck & Co., Inc.
    Inventors: Mark G. Bock, Robert M. DiPardo, Joshua S. Boger, Ben E. Evans, Roger Freidinger
  • Immunogenic HAV peptides
    Patent number: 4596674
    Abstract: Synthetic peptides, containing amino acid residues 15 to 21, 75-80 and 101-107 of the hepatitis A virus (HAV) VP1 structural protein sequence, was prepared and chemically conjugated to a protein carrier molecule. The peptide-carrier conjugate, when inoculated into test animals, gives rise to a specific anti-peptide IgG antibody response. These anti-peptide antibodies bind directly to intact hepatitis A virions, bind to purified and denatured VP1, compete with polyspecific antibody derived from human HAV immune sera, and are capable of neutralizing the infectivity of the virus. The peptide is useful as a synthetic subunit immunogen that stimulates an immune response against HAV.
    Type: Grant
    Filed: September 11, 1984
    Date of Patent: June 24, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Emilio A. Emini, Joshua S. Boger, Joseph V. Hughes
  • Renin inhibitory peptides having PHE.sup.13 delection
    Patent number: 4479941
    Abstract: Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperalaosteronism.
    Type: Grant
    Filed: November 4, 1982
    Date of Patent: October 30, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Daniel F. Veber, Joshua S. Boger, Mark G. Bock
  • Renin inhibitory peptides
    Patent number: 4478826
    Abstract: Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.
    Type: Grant
    Filed: September 3, 1982
    Date of Patent: October 23, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Daniel F. Veber, Joshua S. Boger
  • Renin inhibitors containing a C-terminal disulfide cycle
    Patent number: 4477441
    Abstract: Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.
    Type: Grant
    Filed: September 14, 1983
    Date of Patent: October 16, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Joshua S. Boger, Daniel F. Veber
  • Renin inhibitors containing an n-terminal disulfide cycle
    Patent number: 4477440
    Abstract: Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.
    Type: Grant
    Filed: September 14, 1983
    Date of Patent: October 16, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Joshua S. Boger, Daniel F. Veber
  • Renin inhibitory peptides having His.sup.13
    Patent number: 4470971
    Abstract: Renin inhibitory peptides of the formula ##STR1## and analogs thereof inhibit renin and are useful for treating various forms of renin-associated hypertension and hyperaldosteronism.
    Type: Grant
    Filed: September 3, 1982
    Date of Patent: September 11, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Joshua S. Boger, Daniel F. Veber