Patents by Inventor Joshua Simon KLEIN
Joshua Simon KLEIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11993807Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.Type: GrantFiled: March 7, 2023Date of Patent: May 28, 2024Assignee: Nautilus Subsidiary, Inc.Inventors: Tural Aksel, Torri Rinker, Markus Burns, Michael Dorwart, Rachel Galimidi, Dmitriy Gremyachinskiy, Stephen Hendricks, Elvis Ikwa, Gregory Kapp, Joshua Simon Klein, Julia Robinson, Cassandra Stawicki, Sonal Tonapi, Parag Mallick
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Publication number: 20240018574Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.Type: ApplicationFiled: June 2, 2023Publication date: January 18, 2024Inventors: Tural AKSEL, Torri RINKER, Markus BURNS, Michael DORWART, Rachel GALIMIDI, Dmitriy GREMYACHINSKIY, Stephen HENDRICKS, Elvis IKWA, Gregory KAPP, Joshua Simon KLEIN, Julia ROBINSON, Cassandra STAWICKI, Sonal TONAPI, Parag MALLICK
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Publication number: 20230272459Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.Type: ApplicationFiled: March 7, 2023Publication date: August 31, 2023Inventors: Tural AKSEL, Torri RINKER, Markus BURNS, Michael DORWART, Rachel GALIMIDI, Dmitriy GREMYACHINSKIY, Stephen HENDRICKS, Elvis IKWA, Gregory KAPP, Joshua Simon KLEIN, Julia ROBINSON, Cassandra STAWICKI, Sonal TONAPI, Parag MALLICK
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Patent number: 11692217Abstract: An affinity reagent, having: (a) a retaining component such as a structured nucleic acid particle; and (b) one or both of (i) one or more label components attached to the retaining component, and (ii) one or more binding components attached to the retaining component.Type: GrantFiled: November 10, 2021Date of Patent: July 4, 2023Assignee: Nautilus Subsidiary, Inc.Inventors: Tural Aksel, Torri Rinker, Markus Burns, Michael Dorwart, Rachel Galimidi, Dmitriy Gremyachinskiy, Stephen Hendricks, Elvis Ikwa, Gregory Kapp, Joshua Simon Klein, Julia Robinson, Cassandra Stawicki, Sonal Tonapi, Parag Mallick
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Patent number: 10709391Abstract: Body-mountable devices are provided to detect the presence or status of a tumor in a body by detecting probes associated with circulating cells of the tumor that travel to subsurface vasculature of the body. The probe enters a tumor and associates with cells of the tumor before the cells metastasize. A wearable body-mountable device can be worn for a protracted period of time to detect the probe associated with circulating tumor cells in the vasculature at low concentrations and/or at low rates. A body-mounted device could detect the presence of such released, tumor-cell-associated probes to determine a presence or status of a tumor in the body.Type: GrantFiled: December 2, 2015Date of Patent: July 14, 2020Assignee: Verily Life Sciences LLCInventors: Alberto Clemente Vitari, Andrew Homyk, Joshua Simon Klein, Marija Pavlovic, Jerrod Joseph Schwartz
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Patent number: 10633649Abstract: A method for profiling extracellular vesicles (EV) is provided.Type: GrantFiled: April 21, 2017Date of Patent: April 28, 2020Assignee: Verily Life Sciences LLCInventors: Alberto Clemente Vitari, Joshua Simon Klein, Nathan Higginson-Scott, Nathan Pierce
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Patent number: 10492709Abstract: Body-mountable devices are provided to detect the presence or status of an analyte in subsurface vasculature of a body by detecting fluorescent reporters that are bound to instances of the analyte in the subsurface vasculature. Such devices further operate to exert an attractive magnetic force on magnetic nanoparticle-containing probes that are configured to bind to the analyte, thus concentrating the analyte proximate the devices by magnetically exerting attractive forces on such probes that are bound to instances of the analyte. The analyte can be an extracellular vesicle that is characteristic of a cancer, and a body-mountable device as described herein could be used to detect such extracellular vesicles in a portion of subsurface vasculature such that a presence or status of a tumor could be determined based on an amount, presence, or other detected property of the extracellular vesicle.Type: GrantFiled: October 14, 2016Date of Patent: December 3, 2019Assignee: Verily Life Sciences LLCInventors: Mark Audeh, Joshua Simon Klein, Anthony M Giannetti, Stephen Morton, James Michael Higbie
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Patent number: 10292631Abstract: Body-mountable devices are provided to detect the presence or status of a tumor in a body by detecting one or more properties of a probe located in subsurface vasculature of the body. A wearable body-mountable device can be worn for a protracted period of time to detect a probe in the vasculature at low concentrations and/or at low rates. A body-mountable device can detect properties of the probe that are indicative of whether the probe has interacted with a tumor of the body and determine the presence or status of a tumor in the body based on such detected properties. Additionally or alternatively, the probe could be introduced into the body as a probe aggregate and released from if the probe aggregate is absorbed by a tumor. The presence of released probes could be detected to determine a presence or status of a tumor in the body.Type: GrantFiled: December 3, 2015Date of Patent: May 21, 2019Assignee: Verily Life Sciences LLCInventors: Andrew Homyk, Jerrod Joseph Schwartz, Alberto Clemente Vitari, Joshua Simon Klein, Mark Audeh
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Publication number: 20180228917Abstract: A system is provided which includes nanoparticle conjugates configured to bind with a tumor cell, the nanoparticle conjugate comprising a nanoparticle, at least one targeting entity bound to the nanoparticle, and at least one shielding entity that shields at the at least one targeting entity, the nanoparticle, or both; a body-mountable device mounted on an external surface of a living body and configured to detect a tumor cell binding response signal transmitted through the external surface, wherein the tumor cell binding response signal is related to binding of the nanoparticle conjugates with one or more tumor cells; and a processor configured to non-invasively detect the one or more tumor cells based on the tumor cell response signal. Nanoparticle conjugates and methods for use for treating or imaging tumor cells are also provided.Type: ApplicationFiled: April 13, 2018Publication date: August 16, 2018Inventors: Alberto Clemente Vitari, Joshua Simon Klein, Jerrod Joseph Schwartz, Andrew Homyk, Marija Pavlovic
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Patent number: 9968688Abstract: A system is provided which includes nanoparticle conjugates configured to bind with a tumor cell, the nanoparticle conjugate comprising a nanoparticle, at least one targeting entity bound to the nanoparticle, and at least one shielding entity that shields at the at least one targeting entity, the nanoparticle, or both; a body-mountable device mounted on an external surface of a living body and configured to detect a tumor cell binding response signal transmitted through the external surface, wherein the tumor cell binding response signal is related to binding of the nanoparticle conjugates with one or more tumor cells; and a processor configured to non-invasively detect the one or more tumor cells based on the tumor cell response signal. Nanoparticle conjugates and methods for use for treating or imaging tumor cells are also provided.Type: GrantFiled: November 12, 2014Date of Patent: May 15, 2018Assignee: Verily Life Sciences LLCInventors: Alberto Clemente Vitari, Joshua Simon Klein, Jerrod Joseph Schwartz, Andrew Homyk, Marija Pavlovic
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Patent number: 9927442Abstract: A device and system for detecting an antigen present in a sample is provided. The system includes a cartridge and a reader device. The cartridge includes a solid support having an addressable array of at least one type of antibody that is specific for a target antigen and forms a complex in the presence of the target antigen, a substrate having a mounting surface for the solid support, Protein M for competitively displacing the target antigen from the complex, and a housing for protecting the substrate. The reader device is configured to detect the antigen in a liquid sample via interaction with the cartridge.Type: GrantFiled: December 23, 2014Date of Patent: March 27, 2018Assignee: Verily Life Sciences LLCInventors: Joshua Simon Klein, Vikram Singh Bajaj, Victor Marcel Acosta, Jerrod Joseph Schwartz, Jason Donald Thompson
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Patent number: 9788776Abstract: A wearable device mounted on a living body can detect an analyte response signal transmitted from tissue in the living body. The tissue contains at particles conjugated to at least one complex of (i) an antibody labeled with a fluorophore, the labeled antibody having a target analyte binding site; and (ii) protein M labeled with a quencher that is complimentary to the fluorophore of the labeled antibody, wherein the labeled protein M competes with the target analytes for the target analyte binding site on the labeled antibody; wherein the fluorophore and quencher are spectrally matched such that there is a detectable change in the fluorescent signal. The analyte response signal is related to interaction of the target analytes with the complexes. A processor can determine a presence or absence of the analytes based on the analyte response signal.Type: GrantFiled: September 22, 2014Date of Patent: October 17, 2017Assignee: Verily Life Sciences LLCInventors: Jason Donald Thompson, Jerrod Joseph Schwartz, Joshua Simon Klein
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Publication number: 20170143233Abstract: Body-mountable devices are provided to detect the presence or status of an analyte in subsurface vasculature of a body by detecting fluorescent reporters that are bound to instances of the analyte in the subsurface vasculature. Such devices further operate to exert an attractive magnetic force on magnetic nanoparticle-containing probes that are configured to bind to the analyte, thus concentrating the analyte proximate the devices by magnetically exerting attractive forces on such probes that are bound to instances of the analyte. The analyte can be an extracellular vesicle that is characteristic of a cancer, and a body-mountable device as described herein could be used to detect such extracellular vesicles in a portion of subsurface vasculature such that a presence or status of a tumor could be determined based on an amount, presence, or other detected property of the extracellular vesicle.Type: ApplicationFiled: October 14, 2016Publication date: May 25, 2017Inventors: Mark Audeh, Joshua Simon Klein, Anthony M. Giannetti, Stephen Morton, James Michael Higbie
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Publication number: 20160129131Abstract: A system is provided which includes nanoparticle conjugates configured to bind with a tumor cell, the nanoparticle conjugate comprising a nanoparticle, at least one targeting entity bound to the nanoparticle, and at least one shielding entity that shields at the at least one targeting entity, the nanoparticle, or both; a body-mountable device mounted on an external surface of a living body and configured to detect a tumor cell binding response signal transmitted through the external surface, wherein the tumor cell binding response signal is related to binding of the nanoparticle conjugates with one or more tumor cells; and a processor configured to non-invasively detect the one or more tumor cells based on the tumor cell response signal. Nanoparticle conjugates and methods for use for treating or imaging tumor cells are also provided.Type: ApplicationFiled: November 12, 2014Publication date: May 12, 2016Inventors: Alberto Clemente VITARI, Joshua Simon KLEIN, Jerrod Joseph SCHWARTZ, Andrew HOMYK, Marija PAVLOVIC