Patents by Inventor Joshua Spechler

Joshua Spechler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10646896
    Abstract: A construct that supports cell attachment and alignment including a substrate that is incompatible with photolithography conditions, containing a physical pattern in at least part of one surface, the physical pattern optionally bearing a coating of a metal alkoxide, oxide or mixed oxide-alkoxide thereon and a Self-Assembled Monolayer of Phosphonate (SAMP) covalently attached thereto, which phosphonate contains functionality adapted for cell binding. The construct optionally also contains cells attached thereto. Also disclosed are methods of preparing such a construct.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: May 12, 2020
    Assignee: The Trustees of Princeton University
    Inventors: Jeffrey Schwartz, Joshua Spechler, Romain Fardel, Kelly Lim
  • Publication number: 20180346862
    Abstract: Polymeric substrates, optionally in sheet form, treated with a thin layer of photoresist are perforated by laser ablation. Following removal of the photoresist the polymer substrates perforated with holes are patterned in stripes by photolithography, which is followed by synthesis of a cell-adhesive organometallic/self-assembled monolayer of phosphonate (SAMP) interface in the exposed regions, providing well-aligned continuous stripes for various levels of perforation. Cells plated on each of these 2-dimensional (2D) perforated surfaces attach to the interface and spread in alignment with pattern fidelity that is as high as that measured on a non-perforated, patterned substrate. A stack of such 2D patterned polymers yields a 3-dimensional (3D) device which facilitates cell growth and viability via the perforations.
    Type: Application
    Filed: May 30, 2018
    Publication date: December 6, 2018
    Applicant: The Trustees of Princeton University
    Inventors: Stephen B. Bandini, Joshua Spechler, Craig Arnold, Jeffrey Schwartz
  • Publication number: 20170312780
    Abstract: A construct that supports cell attachment and alignment including a substrate that is incompatible with photolithography conditions, containing a physical pattern in at least part of one surface, the physical pattern optionally bearing a coating of a metal alkoxide, oxide or mixed oxide-alkoxide thereon and a Self-Assembled Monolayer of Phosphonate (SAMP) covalently attached thereto, which phosphonate contains functionality adapted for cell binding. The construct optionally also contains cells attached thereto. Also disclosed are methods of preparing such a construct.
    Type: Application
    Filed: July 13, 2017
    Publication date: November 2, 2017
    Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Jeffrey Schwartz, Joshua Spechler, Romain Fardel, Kelly Lim