Patents by Inventor Joshua SPITZBERG

Joshua SPITZBERG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Light-enhancing plasmonic nanowell-nanopore biosensor and use thereof
    Patent number: 11796531
    Abstract: Systems for detecting fluorescence from a molecule comprising an ion-impermeable film comprising at least one ion-conducting nanopore; a first and second liquid reservoir separated by the film; a means to induce movement of the molecule from the first reservoir to the second reservoir via the nanopore; a light source capable of exciting the molecule to emit fluorescence, wherein the light source shines into the second reservoir; a metallic layer adhered to the film by an adhesion layer and comprising a nanowell structure located adjacent to the nanopore; and a detector configured to detect the fluorescence emitted by the molecule are provided. Methods of use of the systems are also provided.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: October 24, 2023
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Amit Meller, Ossama Assad, Tal Gilboa, Joshua Spitzberg
  • Devices and methods for improved single-molecule detection
    Patent number: 11364499
    Abstract: Devices for detecting a molecule of interest comprising an electrokinetic focusing apparatus and a nanopore apparatus are provided. Kits and systems comprising the apparatus are also provided; as are methods of detecting molecules of interest comprising running the molecules through the electrokinetic focusing apparatus and then detecting the focused molecules as they pass through the nanopore.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: June 21, 2022
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Amit Meller, Moran Bercovici, Xander Frank Van Kooten, Joshua Spitzberg
  • LIGHT-ENHANCING PLASMONIC NANOWELL-NANOPORE BIOSENSOR AND USE THEREOF
    Publication number: 20210003547
    Abstract: Systems for detecting fluorescence from a molecule comprising an ion-impermeable film comprising at least one ion-conducting nanopore; a first and second liquid reservoir separated by the film; a means to induce movement of the molecule from the first reservoir to the second reservoir via the nanopore; a light source capable of exciting the molecule to emit fluorescence, wherein the light source shines into the second reservoir; a metallic layer adhered to the film by an adhesion layer and comprising a nanowell structure located adjacent to the nanopore; and a detector configured to detect the fluorescence emitted by the molecule are provided. Methods of use of the systems are also provided.
    Type: Application
    Filed: December 20, 2018
    Publication date: January 7, 2021
    Inventors: Amit MELLER, Ossama ASSAD, Tal GILBOA, Joshua SPITZBERG
  • DEVICES AND METHODS FOR IMPROVED SINGLE-MOLECULE DETECTION
    Publication number: 20200171489
    Abstract: Devices for detecting a molecule of interest comprising an electrokinetic focusing apparatus and a nanopore apparatus are provided. Kits and systems comprising the apparatus are also provided; as are methods of detecting molecules of interest comprising running the molecules through the electrokinetic focusing apparatus and then detecting the focused molecules as they pass through the nanopore.
    Type: Application
    Filed: May 15, 2018
    Publication date: June 4, 2020
    Inventors: Amit MELLER, Moran BERCOVICI, Xander Frank VAN KOOTEN, Joshua SPITZBERG