Patents by Inventor Joshua Sweetkind-Singer
Joshua Sweetkind-Singer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240002938Abstract: Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.Type: ApplicationFiled: September 7, 2023Publication date: January 4, 2024Applicant: Natera, Inc.Inventors: Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU
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Publication number: 20230212693Abstract: Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.Type: ApplicationFiled: March 13, 2023Publication date: July 6, 2023Applicant: Natera, Inc.Inventors: Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU
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Publication number: 20230193387Abstract: Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.Type: ApplicationFiled: June 9, 2022Publication date: June 22, 2023Applicant: Natera, Inc.Inventors: Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU
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Patent number: 11580420Abstract: Methods, systems, and non-transitory computer readable storage media are disclosed for analyzing feature impact of a machine-learning model using prototypes across analytical spaces. For example, the disclosed system can identify features of data points used to generate outputs via a machine-learning model and then map the features to a feature space and the outputs to a label space. The disclosed system can then utilize an iterative process to determine prototypes from the data points based on distances between the data points in the feature space and the label space. Furthermore, the disclosed system can then use the prototypes to determine the impact of the features within the machine-learning model based on locally sensitive directions; region variability; or mean, range, and variance of features of the prototypes.Type: GrantFiled: January 22, 2019Date of Patent: February 14, 2023Assignee: Adobe Inc.Inventors: Deepak Pai, Joshua Sweetkind-Singer, Debraj Basu
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Patent number: 11449712Abstract: In various embodiments of the present disclosure, output data generated by a deployed machine learning model may be received. An input data anomaly may be detected based at least in part on analyzing input data of the deployed machine learning model. An output data anomaly may further be detected based at least in part on analyzing the output data of the deployed machine learning model. A determination may be made that the input data anomaly contributed to the output data anomaly based at least in part on comparing the input data anomaly to the output data anomaly. A report may be generated that is indicative of the input data anomaly and the output data anomaly, and the report may be transmitted to a client device.Type: GrantFiled: December 14, 2018Date of Patent: September 20, 2022Assignee: Adobe Inc.Inventors: Deepak Pai, Vijay Srivastava, Joshua Sweetkind-Singer, Shankar Venkitachalam
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Publication number: 20220195526Abstract: Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.Type: ApplicationFiled: March 3, 2022Publication date: June 23, 2022Applicant: Natera, Inc.Inventors: Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU
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Publication number: 20220033908Abstract: Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.Type: ApplicationFiled: October 15, 2021Publication date: February 3, 2022Applicant: Natera, Inc.Inventors: Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU
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Patent number: 11111543Abstract: Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.Type: GrantFiled: February 27, 2020Date of Patent: September 7, 2021Assignee: Natera, Inc.Inventors: Matthew Rabinowitz, Milena Banjevic, Zachary Demko, David Johnson, Dusan Kijacic, Dimitri Petrov, Joshua Sweetkind-Singer, Jing Xu
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Patent number: 11111544Abstract: Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.Type: GrantFiled: March 18, 2020Date of Patent: September 7, 2021Assignee: Natera, Inc.Inventors: Matthew Rabinowitz, Milena Banjevic, Zachary Demko, David Johnson, Dusan Kijacic, Dimitri Petrov, Joshua Sweetkind-Singer, Jing Xu
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Publication number: 20210155988Abstract: Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.Type: ApplicationFiled: February 1, 2021Publication date: May 27, 2021Applicant: Natera, Inc.Inventors: Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU
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Publication number: 20210054459Abstract: Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.Type: ApplicationFiled: July 1, 2020Publication date: February 25, 2021Applicant: Natera, Inc.Inventors: Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU
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Publication number: 20200248264Abstract: Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.Type: ApplicationFiled: April 8, 2020Publication date: August 6, 2020Applicant: Natera, Inc.Inventors: Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU
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Publication number: 20200234158Abstract: Methods, systems, and non-transitory computer readable storage media are disclosed for analyzing feature impact of a machine-learning model using prototypes across analytical spaces. For example, the disclosed system can identify features of data points used to generate outputs via a machine-learning model and then map the features to a feature space and the outputs to a label space. The disclosed system can then utilize an iterative process to determine prototypes from the data points based on distances between the data points in the feature space and the label space. Furthermore, the disclosed system can then use the prototypes to determine the impact of the features within the machine-learning model based on locally sensitive directions; region variability; or mean, range, and variance of features of the prototypes.Type: ApplicationFiled: January 22, 2019Publication date: July 23, 2020Inventors: Deepak Pai, Joshua Sweetkind-Singer, Debraj Basu
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Publication number: 20200232036Abstract: Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.Type: ApplicationFiled: March 18, 2020Publication date: July 23, 2020Applicant: Natera, Inc.Inventors: Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU
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Publication number: 20200224273Abstract: Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.Type: ApplicationFiled: March 13, 2020Publication date: July 16, 2020Applicant: Natera, Inc.Inventors: Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU
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Patent number: 10699451Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for accurately, efficiently, and flexibly generating digital graphical representations reflecting multiple data series in-scale utilizing dynamic y-axes. In particular, in one or more embodiments, the disclosed systems generate a normalized graphical representation portraying multiple data series in a common scale with a dynamic y-axis that portrays individualized data values based on user selection of various data series. Specifically, the presently disclosed systems and methods can generate normalized values for each of the included data series, plot the normalized values along a normalized y-axis, and include a dynamic y-axis that reflects the initial values of any of the included data series.Type: GrantFiled: December 18, 2018Date of Patent: June 30, 2020Assignee: ADOBE INC.Inventors: Deepak Pai, Kenneth Hahn, Joshua Sweetkind-Singer
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Publication number: 20200190591Abstract: Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.Type: ApplicationFiled: February 27, 2020Publication date: June 18, 2020Applicant: Natera, Inc.Inventors: Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU
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Publication number: 20200193234Abstract: In various embodiments of the present disclosure, output data generated by a deployed machine learning model may be received. An input data anomaly may be detected based at least in part on analyzing input data of the deployed machine learning model. An output data anomaly may further be detected based at least in part on analyzing the output data of the deployed machine learning model. A determination may be made that the input data anomaly contributed to the output data anomaly based at least in part on comparing the input data anomaly to the output data anomaly. A report may be generated that is indicative of the input data anomaly and the output data anomaly, and the report may be transmitted to a client device.Type: ApplicationFiled: December 14, 2018Publication date: June 18, 2020Inventors: Deepak Pai, Vijay Srivastava, Joshua Sweetkind-Singer, Shankar Venkitachalam
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Publication number: 20200193658Abstract: The present disclosure relates to systems, non-transitory computer-readable media, and methods for accurately, efficiently, and flexibly generating digital graphical representations reflecting multiple data series in-scale utilizing dynamic y-axes. In particular, in one or more embodiments, the disclosed systems generate a normalized graphical representation portraying multiple data series in a common scale with a dynamic y-axis that portrays individualized data values based on user selection of various data series. Specifically, the presently disclosed systems and methods can generate normalized values for each of the included data series, plot the normalized values along a normalized y-axis, and include a dynamic y-axis that reflects the initial values of any of the included data series.Type: ApplicationFiled: December 18, 2018Publication date: June 18, 2020Inventors: Deepak Pai, Kenneth Hahn, Joshua Sweetkind-Singer
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Publication number: 20190276888Abstract: Disclosed herein is a system and method for increasing the fidelity of measured genetic data, for making allele calls, and for determining the state of aneuploidy, in one or a small set of cells, or from fragmentary DNA, where a limited quantity of genetic data is available. Poorly or incorrectly measured base pairs, missing alleles and missing regions are reconstructed using expected similarities between the target genome and the genome of genetically related individuals. In accordance with one embodiment, incomplete genetic data from an embryonic cell are reconstructed at a plurality of loci using the more complete genetic data from a larger sample of diploid cells from one or both parents, with or without haploid genetic data from one or both parents. In another embodiment, the chromosome copy number can be determined from the measured genetic data, with or without genetic information from one or both parents.Type: ApplicationFiled: May 14, 2019Publication date: September 12, 2019Applicant: Natera, Inc.Inventors: Matthew RABINOWITZ, Milena BANJEVIC, Zachary DEMKO, David JOHNSON, Dusan KIJACIC, Dimitri PETROV, Joshua SWEETKIND-SINGER, Jing XU