Patents by Inventor JOSHUA TEMPLE

JOSHUA TEMPLE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BONE REGENERATION USING STROMAL VASCULAR FRACTION, PLATELET-DERIVED GROWTH FACTOR-RICH HYDROGEL, THREE-DIMENSIONAL PRINTED POLY-EPSILON-CAPROLACTONE SCAFFOLDS
    Publication number: 20160095958
    Abstract: The presently disclosed subject matter focuses on recapitulating the heterotypic interactions needed to maximize the co-development of vasculature and bone. More particularly, the presently disclosed subject matter explores the potential of cellular aggregation and temporal presentation of factors to induce the cell-cell signaling events required to stimulate ASCs to self-organize into vascularized bone. Further, exogenous PDGF-BB synergizes complex tissue formation in ASC cultures by enhancing vascular stability and osteogenic differentiation. The presently disclosed approach provides a robust protocol to engineer vascularized bone with ASCs in vitro.
    Type: Application
    Filed: May 28, 2014
    Publication date: April 7, 2016
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: WARREN GRAYSON, COLIN COOK, BEN P.J. HUNG, PINAR HURI, DAPHNE L. HUTTON, JOSHUA TEMPLE