Abstract: An infusion pump includes a reusable housing unit, a disposable reservoir, and a cap fit on the reservoir, wherein the cap includes a conduit for fluid communication. An aseptic connector assembly includes first and second occlusions in the reservoir and the cap. A pull assembly extends from the aseptic connector assembly and forms the first and second occlusions. The pump has three states. In a storage state, the reservoir is separate from the housing unit and the first and second occlusions cooperate to occlude a wet path extending from the reservoir through the conduit in the cap. In a ready state, the reservoir is applied to the housing unit but the wet path is still occluded. In a use state, the reservoir is applied to the housing unit, the first and second occlusions are removed from the aseptic connector assembly, and the wet path is opened for communication.

Abstract: A method of assembling a liquid medicament dispenser, includes the step of providing a housing, a reservoir, a tubing set, an administration line, an aseptic connector assembly having upstream and downstream portions, and a pump. The upstream portion of the aseptic connector assembly is coupled to the reservoir, and the reservoir is filled with a liquid medicament. The downstream portion of the aseptic connector assembly is coupled to the tubing set. The reservoir and the upstream portion of the aseptic connector assembly are sterilized together. The downstream portion of the aseptic connector assembly, the tubing set, and the administration line are sterilized together. The upstream portion of the aseptic connector assembly is connected to the downstream portion of the aseptic connector assembly, and the reservoir, pump, and other elements are mounted in the housing.

Abstract: An infusion pump includes a reusable housing unit, a disposable reservoir, and a cap fit on the reservoir, wherein the cap includes a conduit for fluid communication. An aseptic connector assembly includes first and second occlusions in the reservoir and the cap. A pull assembly extends from the aseptic connector assembly where it forms the first and second occlusions. The pump has three states. In a storage state, the reservoir is separate from the housing unit and the first and second occlusions cooperate to occlude a wet path extending from the reservoir through the conduit in the cap. In a ready state, the reservoir is applied to the housing unit but the wet path is still occluded. In a use state, the reservoir is applied to the housing unit, the first and second occlusions are removed from the aseptic connector assembly, and the wet path is opened for communication.

Abstract: A method of assembling a liquid medicament dispenser, includes the step of providing a housing, a reservoir, a tubing set, an administration line, an aseptic connector assembly having upstream and downstream portions, and a pump. The upstream portion of the aseptic connector assembly is coupled to the reservoir, and the reservoir is filled with a liquid medicament. The downstream portion of the aseptic connector assembly is coupled to the tubing set. The reservoir and the upstream portion of the aseptic connector assembly are sterilized together. The downstream portion of the aseptic connector assembly, the tubing set, and the administration line are sterilized together. The upstream portion of the aseptic connector assembly is connected to the downstream portion of the aseptic connector assembly, and the reservoir, pump, and other elements are mounted in the housing.

Abstract: A liquid medicament dispenser includes a housing and a pump carried by the housing, a reservoir applied to the housing and containing a pre-filled sterile liquid medicament, a sterile tubing set routed through the pump, a sterile administration line carried outside of the housing and coupled aseptically to the sterile tubing set in fluid communication, and an aseptic connector coupled to the reservoir and the sterile tubing set and changeable from a storage state to a use state. In the storage state, the aseptic connector prevents the liquid medicament in the reservoir from moving to the sterile tubing set. In the use state of the aseptic connector, the aseptic connector defines a sterile passageway for the flow of the liquid medicament from the reservoir to the sterile tubing set.

Abstract: A dispensing device and the method of making same for dispensing medicaments to a patient that includes a housing, a first assembly connected to the first end of the housing that includes a body portion, and a penetrating sub-assembly. The first assembly also includes a rate control chip of novel construction that is connected to the penetrating sub-assembly and functions to control the rate of flow of medicinal fluid to the patient. Disposed within the housing is a second assembly that includes a shuttle, a collapsible container carried by the shuttle and a plurality of variable force springs that function to thrust the collapsible container into penetrating engagement with the penetrating member of the penetrating assembly and then to collapse the collapsible container to deliver the medicinal fluid to the patient. Connected to the second end of the housing is a novel third assembly that includes an operating member that functions to controllably move the shuttle forwardly of the housing.

Abstract: A liquid medicament dispenser includes a housing and a pump carried by the housing, a reservoir applied to the housing and containing a pre-filled sterile liquid medicament, a sterile tubing set routed through the pump, a sterile administration line carried outside of the housing and coupled aseptically to the sterile tubing set in fluid communication, and an aseptic connector coupled to the reservoir and the sterile tubing set and changeable from a storage state to a use state. In the storage state, the aseptic connector prevents the liquid medicament in the reservoir from moving to the sterile tubing set. In the use state of the aseptic connector, the aseptic connector defines a sterile passageway for the flow of the liquid medicament from the reservoir to the sterile tubing set.

Abstract: A dispensing device and the method of making same for dispensing medicaments to a patient that includes a housing, a first assembly connected to the first end of the housing that includes a body portion, and a penetrating sub-assembly. The first assembly also includes a rate control chip of novel construction that is connected to the penetrating sub-assembly and functions to control the rate of flow of medicinal fluid to the patient. Disposed within the housing is a second assembly that includes a shuttle, a collapsible container carried by the shuttle and a plurality of variable force springs that function to thrust the collapsible container into penetrating engagement with the penetrating member of the penetrating assembly and then to collapse the collapsible container to deliver the medicinal fluid to the patient. Connected to the second end of the housing is a novel third assembly that includes an operating member that is threadably connected to the shuttle.

Abstract: A compact fluid dispenser for use in controllably dispensing fluid medicaments, such as antibiotics, blood clotting agents, analgesics, and like medicinal agents from collapsible containers at a uniform rate. The dispenser includes a novel stored energy source that is provided in the form of a compressible-expandable member that functions to continuously and uniformly expel fluid from the device reservoir. The apparatus further includes a novel fluid flow control assembly that precisely controls the flow of the medicament solutions from the device reservoir to the patient.

Abstract: This invention is related to the fields of organic chemistry and nanotechnology. In particular, it relates to materials and methods for the preparation of organic synthons and bridged macrocyclic module components. The bridge macrocyclic module compounds may be used to prepare macrocyclic module compositions such as nanofilms, which may be useful for filtration.

Abstract: A dispensing device for dispensing pain management medicaments to a patient comprises first and second threadably interconnectable sub-assemblies. The first of these sub-assemblies houses a fluid reservoir defining component while the second comprises a fluid delivery and control assembly that includes a novel flow control means that functions to control the flow of medicinal fluid from the fluid reservoir of the first sub-assembly toward the patient via strategically formed flow control passageways.

Abstract: A novel dispensing system for dispensing medicaments to a patient that includes means for controllably heating fluid medicaments within the dispensing system by converting a chemical component, such as calcium chloride or the like, into a solution or solvent by adding a suitable solution or solvent to create an exothermic process causing an increase in temperature of the mixed solution.

Abstract: A compact fluid dispenser for use in controllably dispensing fluid medicaments, such as, antibiotics, analgesics, and like medicinal agents from the device reservoir which is provided in the form of a novel bellows type assembly. The fluid dispenser includes a unique stored energy mechanism which takes the form of a constant force spring member of novel design that provides the force necessary to continuously and substantially uniformly expel fluid from the device reservoir. The device also includes novel adjustable flow rate control assembly that is disposed intermediate the fluid reservoir outlet and the outlet port of the device for precisely controlling the rate of fluid flow from the outlet port toward the patient.

Abstract: A compact, nonelectric fluid dispenser for use in controllably dispensing beneficial agents such as propofol and dexmedetomidine hydrochloride to patients. The dispenser includes a fluid flow control assembly that precisely controls the flow of the medicament solution to the patient and embodies a collapsible drug container that can be filled in the field with the beneficial agents to be delivered to the patient. The unit-dose fluid dispenser of the invention is presented in a sterile and aseptic manner, where the drug has been pre-filled in the system, so that the practitioner cannot mistakenly give the wrong drug to the patient. The dispenser uniquely provides a more efficient medicament delivery system for procedure rooms, such as the endoscopy center, so that a greater number of patients can be treated per day at a higher standard of care with increased profits for the healthcare provider.

Abstract: A compact, nonelectric fluid dispenser for use in controllably dispensing beneficial agents such as propofol and dexmedetomidine hydrochloride to patients. The dispenser includes a fluid flow control assembly that precisely controls the flow of the medicament solution to the patient and embodies a collapsible, pre-filled drug container that contains the beneficial agents to be delivered to the patient. The unit-dose fluid dispenser of the invention is presented in a sterile and aseptic manner, where the drug has been pre-filled in the system, so that the practitioner cannot mistakenly give the wrong drug to the patient. The dispenser uniquely provides a more efficient medicament delivery system for procedure rooms, such as the endoscopy center, so that a greater number of patients can be treated per day at a higher standard of care with increased profits for the healthcare provider.

Abstract: A dispensing device for dispensing medicaments to a patient which includes a supporting structure; a carriage assembly interconnected with the supporting structure for movement between a first position and a second position and a semi-rigid, collapsible reservoir carried by the carriage assembly. A stored energy source is operably associated with the carriage assembly for moving the carriage assembly between the first and second positions. The device also includes novel structure, including fill-vials, for adding medicaments to the fluid within the fluid reservoir.

Abstract: A compact, nonelectric fluid dispenser for use in controllably dispensing beneficial agents such as propofol and dexmedetomidine hydrochloride to patients. The dispenser includes a fluid flow control assembly that precisely controls the flow of the medicament solution to the patient and embodies a collapsible, pre-filled drug container that contains the beneficial agents to be delivered to the patient. The unit-dose fluid dispenser of the invention is presented in a sterile and aseptic manner, where the drug has been pre-filled in the system, so that the practitioner cannot mistakenly give the wrong drug to the patient. The dispenser uniquely provides a more efficient medicament delivery system for procedure rooms, such as the endoscopy center, so that a greater number of patients can be treated per day at a higher standard of care with increased profits for the healthcare provider.

Abstract: A compact fluid dispenser for use in controllably dispensing fluid medicaments, such as, antibiotics, analgesics, and like medicinal agents from the device reservoir which is provided in the form of a novel bellows-type assembly. The fluid dispenser includes a unique stored energy mechanism which takes the form of a constant force spring member of novel design that provides the force necessary to continuously and substantially uniformly expel fluid from the device reservoir. The device also includes novel adjustable flow rate control assembly that is disposed intermediate the fluid reservoir outlet and the outlet port of the device for precisely controlling the rate of fluid flow from the outlet port toward the patient.

Abstract: A compact fluid dispenser for use in controllably dispensing fluid medicaments, such as, antibiotics, analgesics, and like medicinal agents from the device reservoir which is provided in the form of a novel collapsible bottle-like assembly. The fluid dispenser includes a unique stored energy mechanism which takes the form of a spring member of novel design that provides the force necessary to continuously and substantially uniformly expel fluid from the device reservoir. The device also includes novel adjustable flow rate control assembly that is disposed intermediate the fluid reservoir outlet and the outlet port of the device for precisely controlling the rate of fluid flow from the outlet port toward the patient.