Patents by Inventor Josiah Brown
Josiah Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230218506Abstract: The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glycolide microsphere formulation containing the active agent. This surprising result suggests that pharmacologically beneficial extended release formulations without the complexities and expense associated with the manufacture microspheres.Type: ApplicationFiled: March 15, 2023Publication date: July 13, 2023Inventor: Josiah Brown
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Publication number: 20210346282Abstract: The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glycolide microsphere formulation containing the active agent. This surprising result suggests that pharmacologically beneficial extended release formulations without the complexities and expense associated with the manufacture microspheres.Type: ApplicationFiled: December 21, 2020Publication date: November 11, 2021Inventor: Josiah Brown
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Publication number: 20190231679Abstract: The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glycolide microsphere formulation containing the active agent. This surprising result suggests that pharmacologically beneficial extended release formulations without the complexities and expense associated with the manufacture microspheres.Type: ApplicationFiled: October 22, 2018Publication date: August 1, 2019Inventor: Josiah Brown
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Publication number: 20180169005Abstract: The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glycolide microsphere formulation containing the active agent. This surprising result suggests that pharmacologically beneficial extended release formulations without the complexities and expense associated with the manufacture microspheres.Type: ApplicationFiled: August 2, 2017Publication date: June 21, 2018Inventor: Josiah Brown
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Publication number: 20140275109Abstract: The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glycolide microsphere formulation containing the active agent. This surprising result suggests that pharmacologically beneficial extended release formulations without the complexities and expense associated with the manufacture microspheres.Type: ApplicationFiled: January 21, 2014Publication date: September 18, 2014Applicant: Alkermes, Inc.Inventor: Josiah Brown
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Patent number: 8759351Abstract: The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glycolide microsphere formulation containing the active agent. This surprising result suggests that pharmacologically beneficial extended release formulations without the complexities and expense associated with the manufacture microspheres.Type: GrantFiled: October 10, 2012Date of Patent: June 24, 2014Assignee: Otsuka Pharmaceutical Co., Ltd.Inventor: Josiah Brown
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Publication number: 20140134253Abstract: The present invention provides an inhaled dry powder formulation containing a combination of fosfomycin salt and tobramycin-leucine compound particles. The use of such formulation for the treatment of patients who have Chronic Obstructive Pulmonary Disease (COPD) and who are experiencing or at risk of experiencing acute exacerbation, as well as patients who have other bacterial infections of the respiratory tract, particularly the lower respiratory tract, and methods for treating the same are also provided.Type: ApplicationFiled: May 6, 2012Publication date: May 15, 2014Applicant: Gilead Sciences, Inc.Inventors: Johnny Lai, Josiah Brown, Kevin W. Stapleton
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Patent number: 8338427Abstract: The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glycolide microsphere formulation containing the active agent. This surprising result suggests that pharmacologically beneficial extended release formulations without the complexities and expense associated with the manufacture microspheres.Type: GrantFiled: October 15, 2008Date of Patent: December 25, 2012Assignee: Alkermes, Inc.Inventor: Josiah Brown
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Patent number: 8338428Abstract: The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glycolide microsphere formulation containing the active agent. This surprising result suggests that pharmacologically beneficial extended release formulations without the complexities and expense associated with the manufacture microspheres.Type: GrantFiled: March 15, 2012Date of Patent: December 25, 2012Assignee: Alkermes, Inc.Inventor: Josiah Brown
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Publication number: 20120289516Abstract: The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glycolide microsphere formulation containing the active agent. This surprising result suggests that pharmacologically beneficial extended release formulations without the complexities and expense associated with the manufacture microspheres.Type: ApplicationFiled: March 15, 2012Publication date: November 15, 2012Applicant: ALKERMES, INC.Inventor: Josiah Brown
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Patent number: 7658998Abstract: The present invention relates to a method for preparing an injectable composition of microparticles for the sustained release of a biologically active agent. The microparticles include a biocompatible polymer and a biologically active agent. The invention provides an improved process for the preparation of microparticles, wherein the physical characteristics of the microparticles, for example, the morphology, density and size, are independent of the process used to prepare the initially formed polymer/drug matrix. The method includes the steps of (a) providing a polymer/biologically active agent matrix; (b) compressing the polymer/biologically active agent matrix, thereby forming a compressed matrix; and (c) fragmenting the compressed matrix, thereby forming an injectable microparticle composition. The polymer/drug matrix can be provided by any suitable method.Type: GrantFiled: January 21, 2004Date of Patent: February 9, 2010Assignee: Alkermes Controlled Therapeutics, Inc.Inventors: Josiah Brown, Warren E. Jaworowicz, Gregory C. Troiano
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Publication number: 20090143403Abstract: The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glycolide microsphere formulation containing the active agent. This surprising result suggests that pharmacologically beneficial extended release formulations without the complexities and expense associated with the manufacture microspheres.Type: ApplicationFiled: October 15, 2008Publication date: June 4, 2009Applicant: Alkermes, Inc.Inventor: Josiah Brown
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Publication number: 20050032811Abstract: The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glycolide microsphere formulation containing the active agent. This surprising result suggests that pharmacologically beneficial extended release formulations without the complexities and expense associated with the manufacture microspheres.Type: ApplicationFiled: August 6, 2003Publication date: February 10, 2005Inventor: Josiah Brown
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Publication number: 20040247870Abstract: The present invention relates to a method for preparing an injectable composition of microparticles for the sustained release of a biologically active agent. The microparticles include a biocompatible polymer and a biologically active agent. The invention provides an improved process for the preparation of microparticles, wherein the physical characteristics of the microparticles, for example, the morphology, density and size, are independent of the process used to prepare the initially formed polymer/drug matrix. The method includes the steps of (a) providing a polymer/biologically active agent matrix; (b) compressing the polymer/biologically active agent matrix, thereby forming a compressed matrix; and (c) fragmenting the compressed matrix, thereby forming an injectable microparticle composition. The polymer/drug matrix can be provided by any suitable method.Type: ApplicationFiled: January 21, 2004Publication date: December 9, 2004Inventors: Josiah Brown, Warren E. Jaworowicz, Gregory C. Troiano
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Patent number: 6499361Abstract: Solid samples having a uniform sorbate content are produced by directing a gas having a constant sorbate pressure through a plurality of containers, each container enclosing a solid sample. The sorbate content of the solid samples equilibrates with the sorbate pressure in the gas, thereby causing the solid samples to have a uniform sorbate content. An apparatus that can be employed to generate solid samples having a uniform sorbate content includes a relative humidity generator, and a manifold which connects the relative humidity generator to a plurality of solid sample containers.Type: GrantFiled: February 18, 2000Date of Patent: December 31, 2002Assignee: Alkermes Controlled Therapeutics, Inc.Inventors: Henry R. Costantino, Josiah Brown