Abstract: The present disclosure is directed to novel lipidated poly(amino acid)s (LPAAs). The present disclosure is further related to processes for preparing such novel lipidated poly(amino acid)s (LPAAs) and for preparing novel lipidated poly(amino acid)s nanoparticles (LPAANPs). Additionally, the present disclosure relates to processes for utilizing lipidated poly(amino acid)s (LPAAs) that are biocompatible and capable of drug delivery.

Abstract: Electrochemistry is used to generate active nitrating species from nitrate salt in situ in an aprotic solvent to eliminate acidic and/or toxic waste streams associated with the production of energetic materials. The systems/methods perform alcohol nitration without using nitric acid and/or sulfuric acid. As a result, the systems/methods may be operated under milder conditions (e.g., room temperature and ambient pressure). In addition, the disclosed systems/methods offer high product selectivity via controlling electrolysis potential. The electrochemical synthetic method is scalable, highly amenable to continuous processing and can make use of inexpensive feedstocks, making the systems/methods well-suited to large-scale manufacture.

Abstract: A system may include a radar-based tracking system, an image-based tracking system, one or more processors, and one or more computer-readable recording media that store instructions that are executable by the one or more processors to configure the system to: (i) obtain, via the radar-based tracking system, radar-based measurement data; (ii) utilize the radar-based measurement data as input to an event detection module to generate event detection output; and (iii) when the event detection output satisfies one or more conditions, selectively activate the image-based tracking system to enable acquisition of image-based tracking data to facilitate positional tracking of an object.

Abstract: One aspect of the present invention is directed to triblock peptides comprising a lipid moiety, a peptide block and a zwitterion-like block. Another aspect of the invention is directed to pharmaceutical compositions comprising the triblock peptides of the present in invention arranged in micelles in a pharmaceutically acceptable carrier. In certain embodiments, the pharmaceutical compositions of the present invention are vaccine compositions, which may further comprise an adjuvant. Another aspect of the invention is directed to methods of using the triblock peptides and compositions of the invention to treat a disease or condition.

Abstract: A electronic display device designed to calibrate brightness levels in a flat-panel display by using adjacent code calibration for a variable electroluminescence voltage supply in the flat-panel display.

Abstract: The present disclosure is directed to novel lipidated poly(amino acid)s (LPAAs). The present disclosure is further related to processes for preparing such novel lipidated poly(amino acid)s (LPAAs) and for preparing novel lipidated poly(amino acid)s nanoparticles (LPAANPs). Additionally, the present disclosure relates to processes for utilizing lipidated poly(amino acid)s (LPAAs) that are biocompatible and capable of drug delivery.

Abstract: The present invention is directed to a composition that includes an amphiphile, its use in a method of preventing and/or treating cancer, and its use in a method of producing a pharmaceutical composition. In certain embodiments, the amphiphile includes a hydrophilic peptide that binds to a Plenty of SH3 domain (POSH) and inhibits or disrupts a POSH scaffold network, a hydrophobic moiety, and an aptamer. The present invention is also directed to other POSH inhibitor complex biomolecules that do not contain a hydrophobic moiety.

Abstract: One aspect of the present invention is directed to triblock peptides comprising a lipid moiety, a peptide block and a zwittenon-like block. Another aspect of the invention is directed to pharmaceutical compositions comprising the triblock peptides of the present in invention arranged in micelles in a pharmaceutically acceptable carrier. In certain embodiments, the pharmaceutical compositions of the present invention are vaccine compositions, which may further comprise an adjuvant. Another aspect of the invention is directed to methods of using the triblock peptides and compositions of the invention to treat a disease or condition.

Abstract: The present invention is directed to a composition that includes an amphiphile, its use in a method of preventing and/or treating cancer, and its use in a method of producing a pharmaceutical composition. In certain embodiments, the amphiphile includes a hydrophilic peptide that binds to a Plenty of SH3 domain (POSH) and inhibits or disrupts a POSH scaffold network, a hydrophobic moiety, and an aptamer. The present invention is also directed to other POSH inhibitor complex biomolecules that do not contain a hydrophobic moiety.

Abstract: The present invention, in certain embodiments, is directed to a peptide amphiphile coating on the hydrophobic surface of an object, such as a medical device, in which non-covalent associations attach the hydrophobic portion of the peptide amphiphile to the hydrophobic surface. Other embodiments of the invention are directed to a method for forming the coating.