Abstract: The present disclosure provides a textured dilatation balloon that includes a balloon body having a proximal end, a distal end, and at least one indentation in the balloon body in an un-inflated state, wherein the balloon body comprises a continuous polymer tube with an external surface having at least one therapeutic agent disposed within the at least one indentation.

Abstract: A drug elution stent includes a stent framework and a drug elution portion disposed on the stent framework. The drug elution portion includes a first sugar layer disposed on the stent framework, at least one therapeutic agent layer disposed on the first sugar layer and a second sugar layer disposed on the at least one therapeutic agent layer. A method of manufacturing a drug elution stent includes the steps of providing a stent having a stent framework and coating at least a portion of the stent framework with a drug elution portion. The drug elution portion includes a first sugar layer disposed on the stent framework, at least one therapeutic agent layer disposed on the first sugar layer and a second sugar layer disposed on the at least one therapeutic agent layer.

Abstract: A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes a catheter having a first inflatable member and a guidewire having a second inflatable member. The catheter has an extended tip distal to the first inflatable member that includes multiple perfusion ports. A light emission coil is disposed on the extended tip with individual coil loops interspaced with the perfusion ports. In a method, the guidewire is delivered to a treatment site within a vessel. The catheter is delivered to the treatment site over the guidewire. The inflatable members are inflated to form an enclosed treatment space within the vessel. A photoinitiator is delivered to the enclosed treatment space. Excess photoinitiator is flushed from the treatment space, and a prepolymer is delivered. The prepolymer is cured by light delivered by the light emission coil.

Abstract: An aortic dissection treatment system and method of use including a treatment system for an aortic dissection having a catheter defining a suction lumen and a sealant lumen; a flexible cup defining an isolation region within the flexible cup, the isolation region being in communication with the suction lumen and the sealant lumen; and a sealant fluid deliverable to the aortic dissection through the sealant lumen and the isolation region. The flexible cup is sized to fit over at least one end of the aortic dissection and the suction lumen applies suction to maintain the flexible cup over the at least one end of the aortic dissection.

Abstract: Disclosed are medical devices and methods for the local delivery and treatment of vascular conditions. The methods and treatments involve local delivery of at least one apolipoprotein. The vascular conditions described herein include plaque rupture, aneurysm, stenosis, restenosis, atherosclerosis, ischemic myocardial infarct and combinations thereof.

Abstract: Implantable medical devices, more specifically stents, are described herein comprising magnesium based core structures whose elimination times are slowed by the appropriate polymer coating. Appropriate biodegradable polymers are selected which are suitable to provide a specific degradation time for the magnesium based core structure. Bioactive agents are incorporated into the polymer coating in order to aid in the therapeutic effect of the stent.

Abstract: A system for treating abnormalities of the cardiovascular system includes a full thickness nanoporous stent having a porous region and at least one therapeutic agent disposed within the porous region. One embodiment includes a full thickness porous cobalt-chromium stent formed by removing magnesium or another sacrificial metal from the stent framework. Another embodiment includes a method of manufacturing a cobalt-chromium stent having full thickness porous regions formed by removing magnesium or another sacrificial metal from the cobalt-chromium alloy comprising the stent framework.

Abstract: A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes a catheter having a first inflatable member and a guidewire having a second inflatable member. The catheter has an extended tip distal to the first inflatable member that includes multiple perfusion ports. A light emission coil is disposed on the extended tip with individual coil loops interspaced with the perfusion ports. In a method, the guidewire is delivered to a treatment site within a vessel. The catheter is delivered to the treatment site over the guidewire. The inflatable members are inflated to form an enclosed treatment space within the vessel. A photoinitiator is delivered to the enclosed treatment space. Excess photoinitiator is flushed from the treatment space, and a prepolymer is delivered. The prepolymer is cured by light delivered by the light emission coil.

Abstract: A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes a catheter having a first inflatable member and a guidewire having a second inflatable member. The catheter has an extended tip distal to the first inflatable member that includes multiple perfusion ports. A light emission coil is disposed on the extended tip with individual coil loops interspaced with the perfusion ports. In a method, the guidewire is delivered to a treatment site within a vessel. The catheter is delivered to the treatment site over the guidewire. The inflatable members are inflated to form an enclosed treatment space within the vessel. A photoinitiator is delivered to the enclosed treatment space. Excess photoinitiator is flushed from the treatment space, and a prepolymer is delivered. The prepolymer is cured by light delivered by the light emission coil.

Abstract: A drug elution stent includes a stent framework and a drug elution portion disposed on the stent framework. The drug elution portion includes a first sugar layer disposed on the stent framework, at least one therapeutic agent layer disposed on the first sugar layer and a second sugar layer disposed on the at least one therapeutic agent layer. A method of manufacturing a drug elution stent includes the steps of providing a stent having a stent framework and coating at least a portion of the stent framework with a drug elution portion.

Abstract: A method for treating a vascular condition includes delivering a magnesium alloy stent framework to a target region of a vessel, leaching at least a portion of magnesium from the magnesium alloy stent framework, and forming a plurality of pores within the stent framework of the stent based on the leaching.

Abstract: Methods for ameliorating stent graft migration and endoleak using treatment site-specific platelet gel compositions in combination with stent grafts are disclosed. Also disclosed are platelet gel compositions directly to treatment sites before, during or after stent graft implantation. Additional embodiments include medical devices having platelet gel coatings and/or platelet gel delivery devices useful for treating aneurysms.

Abstract: Methods and devices are provided to contribute to improved stent graft fixation within vessels at treatment sites. Improved stent graft fixation within vessels at treatment sites is provided by providing stent grafts and methods of making and using stent grafts with bare metal portions having a coating comprising a polymeric material and a cell growth promoting factor.

Abstract: A system for applying a polymer (hydrogel) to the inner surface of a vessel by photopolymerization includes a catheter having a first inflatable member and a guidewire having a second inflatable member. The catheter has an extended tip distal to the first inflatable member that includes multiple perfusion ports. A light emission coil is disposed on the extended tip with individual coil loops interspaced with the perfusion ports. In a method, the guidewire is delivered to a treatment site within a vessel. The catheter is delivered to the treatment site over the guidewire. The inflatable members are inflated to form an enclosed treatment space within the vessel. A photoinitiator is delivered to the enclosed treatment space. Excess photoinitiator is flushed from the treatment space, and a prepolymer is delivered. The prepolymer is cured by light delivered by the light emission coil.

Abstract: Methods and devices for ameliorating stent graft migration and endoleak using treatment site-specific cell growth promoting compositions in combination with stent grafts are disclosed. Also disclosed is coating of autologous growth factor compositions onto stent grafts prior to stent graft implantation. Additional embodiments include stent grafts having autologous growth factor composition coatings useful for treating aneurysms.