Abstract: A subject-specific simulation model of at least one component in the cardiovascular system for simulating blood flow and/or structural features. This simulation model can be used as a tool for cardiovascular diagnostic and/or treatment planning. The invention also regards non-invasive medical imaging of the cardiovascular system. The simulation model of a component in the cardiovascular system, for instance a pumping heart, is reconstructed by combining computational fluid dynamics (CFD) and/or fluid structure interaction (FSI) algorithms with medical imaging, such as for example ultrasound, MRI or CT. Such models make it possible to describe the complex flow phenomenon and provide flow details. The subject-specific model is a tool for clinical decision-making, an objective support for health care professionals in making decisions prior to surgery.