Abstract: Embodiments pertain to a system with a first surface and a second surface operational to associate with one another, where at least one of the first surface and the second surface includes an adhesive layer and a graphite layer positioned on the adhesive layer, and where the graphite layer reduces friction between the first surface and the second surface while the adhesive layer maintains the position of the graphite layer on at least the first surface and the second surface. Additional embodiments pertain to methods of modifying a system that includes a first surface and a second surface by applying an adhesive material to at least one of the first surface and the second surface to form an adhesive layer on at least one of the first surface and the second surface; and applying a graphite material onto the adhesive layer to form a graphite layer on the adhesive layer.

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

Abstract: Systems and methods are provided including a housing configured to receive and engage a hollow tissue structure within a fluid chamber of the housing. A first pair of flow channels and a second pair of flow channels of the housing are fluidly coupled to the fluid chamber. The housing fluidly couples the first pair of flow channels and fluidly couples the second pair of flow channels via a second flow path such that a change in a fluid pressure differential between a first fluid in the first flow path and a second fluid in the second flow path deflects at least a portion of the hollow tissue structure causing a change in flow of the first fluid through the first pair of flow channels or a change in flow of the second fluid through the second pair of flow channels.

Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.

Abstract: The present invention provides engineered valves, tubular structures, and sheets comprising oriented polymeric fibers, e.g., nanofibers, methods of fabricating such structures, and methods of use of such structures as, for example, patches, grafts and valves, e.g., cardiac valves.

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

Abstract: The present invention relates generally to methods of fabricating surface topography based on a scanned surface topography. The method converts 3D scanned surface topography data that have submicron resolution to digital formats that can be stored, manipulated, or tiled, and used as an input for replicating the surface topography with submicron resolution on another substrate. The digitized surface topography data is then converted to input for 1) 3D printing to replicate the scanned surface topography with submicron resolution, with or without a subsequent coating layer or layers to impart additional properties and/or features, 2) 3D printing a master that replicates the scanned surface topography with submicron resolution, which will be used for fast replica molding of the surface topography onto another substrate, and 3) creating a photomask with submicron resolution for transferring the surface topography to a metal substrate surface through subsequent photolithography and etching processes.

Abstract: Exemplary embodiments provide systems, devices and methods for the fabrication of three-dimensional polymeric fibers having micron, submicron and nanometer dimensions, as well as methods of use of the polymeric fibers.

Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.

Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.

Abstract: The present invention relates generally to methods of fabricating surface topography based on a scanned surface topography. The method converts 3D scanned surface topography data that have submicron resolution to digital formats that can be stored, manipulated, or tiled, and used as an input for replicating the surface topography with submicron resolution on another substrate. The digitized surface topography data is then converted to input for 1) 3D printing to replicate the scanned surface topography with submicron resolution, with or without a subsequent coating layer or layers to impart additional properties and/or features, 2) 3D printing a master that replicates the scanned surface topography with submicron resolution, which will be used for fast replica molding of the surface topography onto another substrate, and 3) creating a photomask with submicron resolution for transferring the surface topography to a metal substrate surface through subsequent photolithography and etching processes.

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.

Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.

Abstract: Exemplary embodiments provide in vitro brain models, such as in vitro models of a neurovascular unit or a functionally connected trineural pathway, and systems, devices and methods of use thereof. The present invention provides in vitro brain models, systems, devices and methods that mimic in vivo conditions to, for example, determine the effect of a test compound, such as a drug candidate or a toxin, on various biological responses, such as for example, cell viability, cell growth, migration, differentiation and maintenance of cell phenotype, metabolic activity, structural remodeling and tissue level pre-stress, a neural activity, such as an electrophysiological activity.

Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.

Abstract: The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.