Patents by Inventor Josune Orbe Lopategui

Josune Orbe Lopategui has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antifibrinolytic compounds
    Patent number: 9440989
    Abstract: It relates to spirocyclic compounds of formula (I), or pharmaceutically or veterinary acceptable salts thereof, or any stereoisomers either of the compounds of formula (I) or of their pharmaceutically or veterinary acceptable salts, wherein A and B form a spirocyclic ring system wherein the spiro atom connecting A and B is a carbon atom and wherein A is a known 3- to 8-membered carbocyclic or heterocyclic monocyclic ring or a known 6- to 18-membered carbocyclic or heterocyclic polycyclic ring system; B is a known 4- to 7-membered carbocyclic or heterocyclic monocyclic ring; C is phenyl or a known 5- to 6-membered heteroaromatic ring; and R1-R7 are as defined herein. It also relates to a process for their preparation, as well as to the intermediates used in this process; to pharmaceutical or veterinary compositions containing them, and to their use in medicine, in particular as antifibrinolytic and antihemorragic agents.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: September 13, 2016
    Assignee: PROYECTO DE BIOMEDICINA CIMA, S.L.
    Inventors: Josune Orbe Lopategui, Julen Oyarzabal Santamarina, José Antonio Páramo Fernández, José Antonio Rodriguez Garcia
  • NEW ANTIFIBRINOLYTIC COMPOUNDS
    Publication number: 20150175618
    Abstract: It relates to spirocyclic compounds of formula (I), or pharmaceutically or veterinary acceptable salts thereof, or any stereoisomers either of the compounds of formula (I) or of their pharmaceutically or veterinary acceptable salts, wherein A and B form a spirocyclic ring system wherein the spiro atom connecting A and B is a carbon atom and wherein A is a known 3- to 8-membered carbocyclic or heterocyclic monocyclic ring or a known 6- to 18-membered carbocyclic or heterocyclic polycyclic ring system; B is a known 4- to 7-membered carbocyclic or heterocyclic monocyclic ring; C is phenyl or a known 5- to 6-membered heteroaromatic ring; and R1-R7 are as defined herein. It also relates to a process for their preparation, as well as to the intermediates used in this process; to pharmaceutical or veterinary compositions containing them, and to their use in medicine, in particular as antifibrinolytic and antihemorragic agents.
    Type: Application
    Filed: July 17, 2013
    Publication date: June 25, 2015
    Inventors: Josune Orbe Lopategui, Julen Oyarzabal Santamarina, José Antonio Páramo Fernández, José Antonio Rodriguez Garcia
  • Use of matrix metalloproteinase-10 (MMP-10) for thrombolytic treatments
    Patent number: 8541370
    Abstract: The present invention relates to the use of matrix metalloproteinase MMP-10 in the preparation of a pharmaceutical composition useful for thrombolytic therapy, it also being possible for said composition to contain a plasminogen activator. Additionally, the present invention relates to said pharmaceutical composition for the treatment of thrombotic disorders.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: September 24, 2013
    Assignee: Proyecto de Biomedicina Cima, S.L.
    Inventors: Josune Orbe Lopategui, Jose Antonio Rodriguez Garcia, Jose Antonio Paramo Fernandez, Rosario Serrano Vargas
  • Methods for anti-fibrinolytic treatment using MMP-10 neutralizing antibody
    Patent number: 8257701
    Abstract: The present invention concerns the use of a neutralizing antibody for matrix metalloproteinase-10 (MMP-10) in the preparation of a medicine useful for anti-fibrinolytic treatment, and for hemorrhages and hemorrhagic complications of various etiologies.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: September 4, 2012
    Assignee: Proyecto de Biomedicina Cima, S.L.
    Inventors: Josune Orbe Lopategui, Jóse Antonio Rodríguez García, José Antonio Páramo Fernández, Rosario Serrano Vargas
  • USE OF MATRIX METALLOPROTEINASE-10 (MMP-10) FOR THROMBOLYTIC TREATMENTS
    Publication number: 20110091436
    Abstract: The present invention relates to the use of matrix metalloproteinase MMP-10 in the preparation of a pharmaceutical composition useful for thrombolytic therapy, it also being possible for said composition to contain a plasminogen activator. Additionally, the present invention relates to said pharmaceutical composition for the treatment of thrombotic disorders.
    Type: Application
    Filed: August 23, 2010
    Publication date: April 21, 2011
    Inventors: Josune Orbe Lopategui, Jose Antonio Rodriguez Garcia, Jose Antonio Paramo Fernandez, Rosario Serrano Vargas
  • COMPOSITIONS FOR ANTI-FIBRINOLYTIC TREATMENT
    Publication number: 20100135986
    Abstract: The present invention concerns the use of a neutralising antibody for matrix metalloproteinase-10 (MMP-10) in the preparation of a medicine useful for anti-fibrinolytic treatment, and for haemorrhages and haemorrhagic complications of various etiologies.
    Type: Application
    Filed: June 26, 2008
    Publication date: June 3, 2010
    Inventors: Josune Orbe Lopategui, José Antonio Rodríguez García, José Antonio Páramo Fernández, Rosario Serrano Vargas
  • USE OF MATRIX METALLOPROTEINASE-10 (MMP-10) FOR THROMBOLYTIC TREATMENTS
    Publication number: 20100040596
    Abstract: The present invention relates to the use of matrix metalloproteinase MMP-10 in the preparation of a pharmaceutical composition useful for thrombolytic therapy, it also being possible for said composition to contain a plasminogen activator. Additionally, the present invention relates to said pharmaceutical composition for the treatment of thrombotic disorders.
    Type: Application
    Filed: February 11, 2008
    Publication date: February 18, 2010
    Inventors: Josune Orbe Lopategui, Jose Antonio Rodriguez Garcia, Jose Antonio Paramo Fernandez, Rosario Serrano Vargas