Abstract: A medical device and a method of use thereof for frameless stereotaxy guided intracranial surgery. The medical device includes a central section made from a material that is transparent to ultrasound providing a sonic window, and an ultrasound reflective frame surrounding the central section. The method includes the steps of registering the ultrasound reflective frame with the frameless stereotaxy system for localization of the medical device during surgery. The medical device allows use of ultrasound imaging wherein the output of ultrasound imaging can be computationally combined with MRI or CT imaging data to compensate for anatomical changes in brain during surgery and enhanced localization and navigation to the surgery target.

Abstract: Systems and methods for measuring intracranial pressure and brain compliance are provided. In one aspect, for example, a method for noninvasive measurement of brain compliance in a subject may include calculating a phase shift between an intracranial pulsatile perfusion flow measured from the subject and an extracranial pulsatile perfusion flow measured from the subject, and determining brain compliance of the subject from the phase shift between the intracranial pulsatile perfusion flow and an extracranial pulsatile perfusion flow. Though various methods of calculating phase shift are contemplated, in one aspect such a calculation may include calculating an intracranial frequency waveform corresponding to the intracranial pulsatile perfusion flow, calculating an extracranial frequency waveform corresponding to the extracranial pulsatile perfusion flow, and calculating a phase difference between the intracranial frequency waveform and the extracranial frequency waveform.