Patents by Inventor Jotiram PALKAR

Jotiram PALKAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12226385
    Abstract: The invention discloses herein related to synergistic combination of exogenous bioactives for activating intracellular secondary messenger (cAMP) signalling pathway. Particularly, the invention relates to synergistic compositions comprising combination of therapeutically effective amount of (3R)-3-acetyloxy-4-(trimethylazaniumyl) butanoate and N-4-aminobutylguanidine and salts thereof present in a weight ratio of 1:0.01 to 1:2 along with pharmaceutically acceptable excipients. Furthermore, the composition is useful for treating disease conditions or disorders related to depletion of secondary messenger pathway. The present invention further provides method of treating disease conditions related mental illness or disorder.
    Type: Grant
    Filed: June 14, 2022
    Date of Patent: February 18, 2025
    Assignee: CELAGENEX RESEARCH (INDIA) PRIVATE LTD.
    Inventors: Rajaram Samant, Rajendra Prasad Tongra, Jotiram Palkar
  • Publication number: 20240277681
    Abstract: The invention disclosed herein relates to synergistic bioactive compositions for inhibiting vascular calcification. Particularly, the present invention relates to exogenous blend of magnesium 2-acetylamino ethane sulfonic acid and 2-methyl-4-aminomethyl-5-hydroxymethyl-3-pyridinol and salts thereof which are present in the weight ratio of 1:0.002 to 1:1.8 along with pharmaceutically acceptable excipients. More particularly, the synergistic composition is useful for treating cardiovascular diseases and renal vascular diseases.
    Type: Application
    Filed: June 15, 2022
    Publication date: August 22, 2024
    Inventors: Rajaram SAMANT, Rajendra Prasad T., Jotiram PALKAR
  • Patent number: 11925195
    Abstract: The present invention disclosed herein relates to synergistic compositions for cerebrovascular diseases. In particular, the invention relates to synergistic, efficient, composition for treating cerebral ischemia or stroke comprising specific combination of standardized celery seed extract (CSE) enriched with Dl-3-N-Butylphthalide (NBP) and SIRT1 activators, wherein D1-3-N-Butylphthalide (NBP) and SIRT1 activator are present in a weight ratio of 1:0.1 to 1:5 along with pharmaceutically acceptable excipients.
    Type: Grant
    Filed: October 31, 2020
    Date of Patent: March 12, 2024
    Assignee: CELAGENEX RESEARCH (INDIA) PVT. LTD.
    Inventors: Jotiram Palkar, Rajendra Prasad Tongra
  • Publication number: 20230050208
    Abstract: The present invention disclosed herein relates to synergistic compositions for cerebrovascular diseases. In particular, the invention relates to synergistic, efficient, composition for treating cerebral ischemia or stroke comprising specific combination of standardized celery seed extract (CSE) enriched with Dl N-Butylphthalide (NBP) and SIRT1 activators, wherein Dl-3-N-Butylphthalide (NBP) and SIRT1 activator are present in a weight ratio of 1:0.1 to 1:5 along with pharmaceutically acceptable excipients.
    Type: Application
    Filed: October 31, 2020
    Publication date: February 16, 2023
    Applicant: CELAGENEX RESEARCH (INDIA) PVT. LTD.
    Inventors: Jotiram PALKAR, Rajendra Prasad TONGRA
  • Publication number: 20220313638
    Abstract: The invention discloses herein related to synergistic combination of exogenous bioactives for activating intracellular secondary messenger (cAMP) signalling pathway. Particularly, the invention relates to synergistic compositions comprising combination of therapeutically effective amount of (3R)-3-acetyloxy-4-(trimethylazaniumyl) butanoate and N-4-aminobutylguanidine and salts thereof present in a weight ratio of 1:0.01 to 1:2 along with pharmaceutically acceptable excipients. Furthermore, the composition is useful for treating disease conditions or disorders related to depletion of secondary messenger pathway. The present invention further provides method of treating disease conditions related mental illness or disorder.
    Type: Application
    Filed: June 14, 2022
    Publication date: October 6, 2022
    Applicant: CELAGENEX RESEARCH (INDIA) PRIVATE LTD.
    Inventors: Rajaram SAMANT, Rajendra Prasad TONGRA, Jotiram PALKAR
  • Patent number: 11285167
    Abstract: The present invention disclosed herein provides synergistic nutritional neuroprotective compositions for ameliorating neural dysfunction. Particularly, the invention relates to synergistic, efficient, nutritional composition for comprising specific combination of decarboxylated L-arginine called agmatine sulphate and nicotinamide riboside chloride, wherein agmatine sulphate and nicotinamide riboside chloride are present in the weight ratio of 1:0.05 to 1:2 along with pharmaceutically acceptable excipients. More particularly, the present invention offers synergistic effect for ameliorating neural dysfunction encompasses cerebrovascular diseases, neurodevelopmental disorders, mood disorders, mental health disorders and like thereof.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: March 29, 2022
    Assignee: CELAGENEX RESEARCH (INDIA) PVT. LTD.
    Inventors: Jotiram Palkar, Rajendra Prasad Tongra
  • Patent number: 11166941
    Abstract: The invention disclosed herein relates to synergistic nutritional compositions for enhancing cellular ATP efficiency. Particularly, the invention relates to a synergistic, efficient, nutritional composition for promoting cellular ATP production comprising a therapeutically active exogenous combination of a stabilized oxaloacetate and a biotin-manganese complex along with pharmaceutically acceptable excipients; wherein the stabilized oxaloacetate and the biotin-manganese or salts thereof are present in a weight ratio ranging from 1:0.01 to 1:0.2. Further, the present synergistic nutritional composition is useful for treating ATP deficiency disorders, age-related metabolic disorders, neurodegenerative diseases, cardiovascular diseases, bone related disorders, central nervous system diseases, cognitive disorders and like thereof.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: November 9, 2021
    Assignee: CELAGENEX RESEARCH (INDIA) PVT. LTD.
    Inventors: Jotiram Palkar, Rajendra Prasad Tongra
  • Publication number: 20210196686
    Abstract: The invention disclosed herein relates to synergistic nutritional compositions for enhancing cellular ATP efficiency. Particularly, the invention relates to a synergistic, efficient, nutritional composition for promoting cellular ATP production comprising a therapeutically active exogenous combination of a stabilized oxaloacetate and a biotin-manganese complex along with pharmaceutically acceptable excipients; wherein the stabilized oxaloacetate and the biotin-manganese or salts thereof are present in a weight ratio ranging from 1:0.01 to 1:0.2. Further, the present synergistic nutritional composition is useful for treating ATP deficiency disorders, age-related metabolic disorders, neurodegenerative diseases, cardiovascular diseases, bone related disorders, central nervous system diseases, cognitive disorders and like thereof.
    Type: Application
    Filed: January 4, 2021
    Publication date: July 1, 2021
    Applicant: CELAGENEX RESEARCH (INDIA) PVT. LTD.
    Inventors: Jotiram PALKAR, Rajendra Prasad TONGRA
  • Publication number: 20210128593
    Abstract: The present invention disclosed herein provides synergistic nutritional neuroprotective compositions for ameliorating neural dysfunction. Particularly, the invention relates to synergistic, efficient, nutritional composition for comprising specific combination of decarboxylated L-arginine called agmatine sulphate and nicotinamide riboside chloride, wherein agmatine sulphate and nicotinamide riboside chloride are present in the weight ratio of 1:0.05 to 1:2 along with pharmaceutically acceptable excipients. More particularly, the present invention offers synergistic effect for ameliorating neural dysfunction encompasses cerebrovascular diseases, neurodevelopmental disorders, mood disorders, mental health disorders and like thereof.
    Type: Application
    Filed: November 2, 2020
    Publication date: May 6, 2021
    Applicant: CELAGENEX RESEARCH (INDIA) PVT. LTD.
    Inventors: Jotiram PALKAR, Rajendra Prasad TONGRA