Abstract: Disclosed are devices and methods for dissolving sample substances such as drug molecules. Also disclosed is use of the method for device for testing dissolution rates of the sample substances. It utilizes lyophilic matrices that create conditions for discriminating the dissolved sample substance from undissolved sample substances. This is aimed at preventing dispersion of the undissolved sample substance to avoid any substantial membrane effects.

Abstract: An analysis method and device including detecting at least one particle of matter in a fluid inside in a reaction chamber and correlating a change in the particle to a physicochemical property of the matter.

Abstract: An analysis method and device including detecting at least one particle of matter in a fluid inside in a reaction chamber and correlating a change in the particle to a physicochemical property of the matter.

Abstract: Disclosed are devices and methods for dissolving sample substances such as drug molecules. Also disclosed is use of the method for device for testing dissolution rates of the sample substances. It utilizes lyophilic matrices that create conditions for discriminating the dissolved sample substance from undissolved sample substances. This is aimed at preventing dispersion of the undissolved sample substance to avoid any substantial membrane effects.

Abstract: An analysis method and device including detecting at least one particle of matter in a fluid inside in a reaction chamber and correlating a change in the particle to a physicochemical property of the matter.

Abstract: The invention relates to a method and a device for producing nanoparticles of organic substances, in particular by controlled expansion of pressurized solutions. The method comprises: admixing the organic substance and a supercritical fluid to form a mixture at a first pressure; decreasing the first pressure gradually to a second pressure so that a flow of the mixture is formed and nucleation of the organic substance in the mixture is initiated; and, decreasing the second pressure to a third pressure, so that solidification of the fluid of the mixture, comprising the nucleated organic substance, is initiated. The device comprises: a pressure chamber (1) for a mixture of the organic substance and a supercritical fluid; a collection chamber (5) for the nanoparticles; an outlet tube (2) connecting the pressure chamber to the collection chamber (5); and, one or more second nozzles (6).

Abstract: The present invention relates to a device and a method for producing polymer fibers, in particular to nozzle-less electrospinning devices and methods to produce fibers and constructs thereof, wherein the nanofibers are generated by using pulsed and/or bursted ultrasound.

Abstract: The invention relates to a method and a device for producing nanoparticles of organic substances, in particular by controlled expansion of pressurized solutions. The method comprises: admixing the organic substance and a supercritical fluid to form a mixture at a first pressure; decreasing the first pressure gradually to a second pressure so that a flow of the mixture is formed and nucleation of the organic substance in the mixture is initiated; and, decreasing the second pressure to a third pressure, so that solidification of the fluid of the mixture, comprising the nucleated organic substance, is initiated. The device comprises: a pressure chamber (1) for a mixture of the organic substance and a supercritical fluid; a collection chamber (5) for the nanoparticles; an outlet tube (2) connecting the pressure chamber to the collection chamber (5); and, one or more second nozzles (6).

Abstract: The invention relates to a measuring method for measuring the properties of a powder or granular sample (1) from the surface information of the sample. According to the method the sample is leveled for the measurement, at least one image of the surface of the sample (1) is taken and the properties, such as the grain-size distribution, of the sample (1) are determined by processing the information material by calculation. According to the invention, the sample (1) is made to be supported on a transparent sample plate (2, 13, 14, 15) and an image is taken through this sample plate (2, 13, 14, 15).

Abstract: The invention relates to a measuring method for measuring the properties of a powder or granular sample (1) from the surface information of the sample. According to the method the sample is leveled for the measurement, at least one image of the surface of the sample (1) is taken and the properties, such as the grain-size distribution, of the sample (1) are determined by processing the information material by calculation. According to the invention, the sample (1) is made to be supported on a transparent sample plate (2, 13, 14, 15) and an image is taken through this sample plate (2, 13, 14, 15).

Abstract: The disclosure pertains to a method for preparing a protein-based film wherein modified protein containing free sulfhydryl groups is added to a solution containing protein and the free sulfhydryl groups cause an interchange reaction wherein disulfide bonds will be formed between proteins to form a film structure to coat a product. The disclosure also pertains to a protein-based film.

Abstract: A method for producing a fatty blend of &bgr;-sitosterol, or of &bgr;-sitosterol and &bgr;-sitostanol, which is useful for lowering the serum total cholesterol and LDL-cholesterol levels which method includes forming a mixture by dissolving 0.5-80 wt % of a starting material containing &bgr;-sitosterol, or &bgr;-sitosterol and &bgr;-sitostanol, in 5-90 wt % of oil or fat, or mixtures thereof, by heating at a temperature of 80-140° C. until the starting material containing &bgr;-sitosterol or &bgr;-sitosterol and &bgr;-sitostanol is dissolved; cooling the mixture to a temperature of 40-80° C.; during the cooling adding 5-30 wt % of water with a temperature essentially similar to that of the mixture to the mixture, and agitating the mixture and the water to form a homogeneous and stable dispersion of the mixture in the water, wherein the starting material containing &bgr;-sitosterol or &bgr;-sitosterol and &bgr;-sitostanol is partly dissolved and/or microcrystalline form.

Abstract: The invention relates to starch capsules which protect various substances, such as peptides, proteins, particularly pharmaceutical peptides and proteins, drugs or flavouring agents or spices or enzymes against the effect of the environment or the intestines. Filled starch granules are coated with a suitable biopolymer such as starch or amylose.

Abstract: The object of the invention is a process for the preparation of drug pellets, which method comprises the stages according to which: a drug containing powder is granulated in a rotor type granulator, by exerting a centrifugal force on the powder in the rotor and bringing it, at the periphery of the rotor or adjacent thereto, in contact with a granulating liquid fed separately into the rotor and converted to a mist therein, to which granulating liquid an anti-adhesion agent in an amount of 0.001-5% of the weight of the granulating liquid has been added; the granulate is extruded; and the extrudate obtained is spheronized to pellets which are dried and optionally coated.