Patents by Inventor Joy D. Applebaum

Joy D. Applebaum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast
    Patent number: 4876242
    Abstract: A synthetic gene encoding a 71-amino acid analog of human insulin-like grouwth factor (hIGF-I) has been constructed and expressed in the yeast, Saccharomyces cerevisiae. The protein analog, IGF132, contains the first 17 amino acids of the B chain of human insulin in place of the first 16 amino acids of hIGF-I. The purified hybrid protein has high affinity for the type I IGF recepto (12 nM) yet has drastically reduced affinity for human serum carrier proteins (>1000 nM). This analog is 5 to 10 times more active than normal hIGF-I in stimulating DNA synthesis in 3T3 cells and is a more active growth factor in vivo due to its reduced affinity for serum carrier proteins. Other proteins with similar properties have also been constructed.
    Type: Grant
    Filed: September 21, 1987
    Date of Patent: October 24, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Joy D. Applebaum, Marvin L. Bayne, Margaret A. Cascieri