Patents by Inventor Joy Kovar
Joy Kovar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11167046Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.Type: GrantFiled: November 18, 2019Date of Patent: November 9, 2021Assignee: LI-COR, INC.Inventors: Daniel R. Draney, William M. Volcheck, Katie Schaepe, Vassil Elitzin, Joy Kovar
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Publication number: 20200085976Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.Type: ApplicationFiled: November 18, 2019Publication date: March 19, 2020Applicant: LI-COR, INC.Inventors: Daniel R. Draney, William M. Volcheck, Katie Schaepe, Vassil Elitzin, Joy Kovar
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Publication number: 20180339048Abstract: The present invention provides compositions and methods of use of nanoparticle-based probes for in vivo imaging and therapy. The probes can be used to track diseased target cells by non-invasive imaging in the near-infrared range. Additionally, the probes can induce cell death of the target cells via photodynamic treatment.Type: ApplicationFiled: July 26, 2018Publication date: November 29, 2018Applicant: LI-COR, Inc.Inventors: David L. Dilley, Joy Kovar
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Patent number: 10064943Abstract: The present invention provides compositions and methods of use of nanoparticle-based probes for in vivo imaging and therapy. The probes can be used to track diseased target cells by non-invasive imaging in the near-infrared range. Additionally, the probes can induce cell death of the target cells via photodynamic treatment.Type: GrantFiled: June 2, 2015Date of Patent: September 4, 2018Assignee: LI-COR, Inc.Inventors: David L. Dilley, Joy Kovar
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Publication number: 20160144058Abstract: A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-phenoxycyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate or 2-((E)-2-((E)-3-(2-((E)-3,3-dimethyl-5-sulfonato-1-(4-sulfonatobutyl)indolin-2-ylidene)ethylidene)-2-(4-sulfonatophenoxy)cyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-1-(4-sulfonatobutyl)-3H-indol-1-ium-5-sulfonate. In one embodiment, the organ includes one or more of kidney, bladder, liver, gall bladder, spleen, intestine, heart, lungs and muscle.Type: ApplicationFiled: November 23, 2015Publication date: May 26, 2016Applicant: Ll-COR, INC.Inventors: Daniel R. Draney, WILLIAM M. VOLCHECK, KATIE SCHAEPE, VASSIL ELITZIN, JOY KOVAR
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Publication number: 20130052637Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.Type: ApplicationFiled: August 29, 2012Publication date: February 28, 2013Applicant: LI-COR, INC.Inventors: Joy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
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Patent number: 8303936Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.Type: GrantFiled: June 15, 2012Date of Patent: November 6, 2012Assignee: Li-Cor, Inc.Inventors: Daniel R. Draney, Ananda G. Lugade, Narasimhachari Narayanan, Joy Kovar, D. Michael Olive
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Publication number: 20120258048Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.Type: ApplicationFiled: June 15, 2012Publication date: October 11, 2012Applicant: LI-COR, INC.Inventors: Joy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
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Patent number: 7597878Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.Type: GrantFiled: May 19, 2006Date of Patent: October 6, 2009Assignee: Li-Cor, Inc.Inventors: Joy Kovar, Jiyan Chen, Daniel R. Draney, D. Michael Olive, William M. Volcheck, Xinshe Xu, Ananda G. Lugade, Narasimhachari Narayanan
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Publication number: 20060280688Abstract: Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.Type: ApplicationFiled: May 19, 2006Publication date: December 14, 2006Applicant: LI-COR, Inc.Inventors: Joy Kovar, Jiyan Chen, Daniel Draney, D. Olive, William Volcheck, Xinshe Xu, Ananda Lugade, Narasimhachari Narayanan