Abstract: A series of pharmaceutical metal complexes (pMCs) were produced and characterized using the mast cell stabilizer, cromolyn, and bioactive metal ions (Zn+2, Mg+2, and Ca+2). Three novel pMCs, Cromolyn-Zn, Cromolyn-Mg, and Cromolyn-Ca were formed through reactions under controlled temperature and pH conditions. TGA demonstrated that these metal complexes showed an enhanced thermal stability due to the strong coordination with the ligand, cromolyn. PXRD data indicates a high degree of crystallinity as well as a unique packing arrangement for each pMCs. SEM analysis showed materials with well-defined morphologies while EDS presented elemental evidence for the unique composition of each pMCs. The crystal structure for these materials was elucidated through SCXRD, and a variety of binding modes and packing motifs were found within each respective metal complex. Only 2D structures were achieved under the conditions studied.

Abstract: A siloxane-based lubricant composition contains a mixture of nonreactive and reactive polydimethylsiloxanes, crosslinker and sufficient amounts of surfactant and water to provide an emulsion. The composition contains no methyl hydrogen silane, dimethyl hydrogen silane and/or polymethyl hydrogen siloxane and therefore releases no hydrogen gas during storage or during use.