Abstract: An intravenous line flushing device for preventing clotting of blood by the addition of saline solution to an intravenous line. The intravenous line flushing device includes a sleeve having an inner panel and an outer panel. Each of the panels has a top edge and a bottom edge. The top edge of the inner panel is integrally coupled to the top edge of the outer panel, and the bottom edge of the inner panel is integrally coupled to the bottom edge of the outer panel such that a space is defined between the inner and outer panels. The inner and outer panels are substantially air impermeable. A generally sealed container is positioned in the space between the inner and outer panels. A first agent is disposed in the space. A second agent is disposed in the container. Breaking the container mixes the first and second agents such that a gas is produced, which inflates the sleeve. A primary tube has a first end and a second end. The first end is adapted to removably fluidly engage a pouch.