Patents by Inventor Joyce Reid
Joyce Reid has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4738978Abstract: Bisthioamide-7-oxabicycloheptane prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; R is CO.sub.2 H, CO.sub.2 lower alkyl or ##STR2## q is 1 to 12; and R.sup.1 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, lower alkyl-S-aryl-S-, arylalkyl-S-, ##STR3## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl.The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.Type: GrantFiled: November 10, 1986Date of Patent: April 19, 1988Assignee: E. R. Squibb & Sons, Inc.Inventors: Masami Nakane, Joyce Reid
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Patent number: 4734425Abstract: 7-Oxabicycloheptane substituted hydroxamic acid prostaglandin analogs are provided having the structural formula ##STR1## wherein A is --CH.dbd.CH-- or --CH.sub.2 -CH.sub.2 --; n is 1 to 5; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR2## wherein R.sup.4 and R.sup.5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.4 and R.sup.5 being other than hydroxy and lower alkoxy; q is 1 to 12, R.sup.1 is H or OH; R.sup.2 is OH or H, provided that one of R.sup.1 and R.sup.2 is OH and the other is H; and R.sup.3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, ##STR3## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl.The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.Type: GrantFiled: October 17, 1986Date of Patent: March 29, 1988Assignee: E. R. Squibb & Sons, Inc.Inventors: Masami Nakane, Joyce Reid
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Patent number: 4734424Abstract: Bicycloheptane substituted amide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR3## wherein R.sup.4 and R.sup.5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.4 and R.sup.5 being other than hydroxy and lower alkoxy; p is 1 to 4; R.sup.1 is H or lower alkyl; q is 1 to 12; R.sup.2 is H or lower alkyl; and R.sup.3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, lower alkyl-S-, aryl-S-, arylalkyl-S-, ##STR4## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl.Type: GrantFiled: September 24, 1986Date of Patent: March 29, 1988Assignee: E. R. Squibb & Sons, Inc.Inventors: Steven E. Hall, Joyce Reid
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Patent number: 4663336Abstract: 7-Oxabicycloheptane substituted amide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR3## wherein R.sup.4 and R.sup.5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.4 and R.sup.5 being other than hydroxy and lower alkoxy; p is 1 to 4; R.sup.1 is H or lower alkyl; q is 1 to 12; R.sup.2 is H or lower alkyl; and R.sup.3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aryloxy, arylalkyloxy, amino, alkylamino arylamino, arylalkylamino, ##STR4## (wherein n' is 0, 1 or 2), alkylaminoalkyl, arylaminoalkyl, arylalkylaminoalkyl, alkoxyalkyl, aryloxyalkyl or arylalkoxyalkyl.Type: GrantFiled: April 18, 1986Date of Patent: May 5, 1987Assignee: E. R. Squibb & Sons, Inc.Inventors: Masami Nakane, Joyce Reid
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Patent number: 4654356Abstract: 7-Oxabicycloheptane substituted diacid diamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR3## wherein R.sup.4 and R.sup.5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.4 and R.sup.5 being other than hydroxy and lower alkoxy; p is 1 to 4; R.sup.1 is H or lower alkyl; q is 1 to 12; R.sup.2 and R.sup.3 are the same or different and are H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aralkyloxy or cycloalkyl.The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.Type: GrantFiled: August 1, 1985Date of Patent: March 31, 1987Assignee: E. R. Squibb & Sons, Inc.Inventors: Masami Nakane, Joyce Reid
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Patent number: 4654355Abstract: 7-Oxabicycloheptane substituted amide-thioamide prostaglandin analogs are provided having the structural formula ##STR1## wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH--, --CH.sub.2 --, ##STR2## or a single bond; R is CO.sub.2 H, CO.sub.2 alkyl, CO.sub.2 alkali metal, CO.sub.2 polyhydroxyamine salt, --CH.sub.2 OH, ##STR3## wherein R.sup.4 and R.sup.5 are the same or different and are H, lower alkyl, hydroxy, lower alkoxy or aryl, at least one of R.sup.4 and R.sup.5 being other than hydroxy and lower alkoxy; p is 1 to 4; R.sup.1 is H or lower alkyl; q is 1 to 12; R.sup.2 is H or lower alkyl; and R.sup.3 is H, lower alkyl, lower alkenyl, lower alkynyl, aryl, arylalkyl, lower alkoxy, aralkyloxy, amino, alkylamino, or arylamino.The compounds are cardiovascular agents useful, for example, in the treatment of thrombotic disease.Type: GrantFiled: August 1, 1985Date of Patent: March 31, 1987Assignee: E. R. Squibb & Sons, Inc.Inventors: Masami Nakane, Joyce Reid
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Patent number: 4456615Abstract: 7-Oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.Type: GrantFiled: October 25, 1982Date of Patent: June 26, 1984Assignee: E. R. Squibb & Sons, Inc.Inventors: Masami Nakane, David L. Snitman, Joyce Reid, Martin F. Haslanger
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Patent number: 4418076Abstract: 7-Oxabicycloheptane hydrazone prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. pa The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.Type: GrantFiled: May 3, 1982Date of Patent: November 29, 1983Assignee: E. R. Squibb & Sons, Inc.Inventors: Masami Nakane, Joyce Reid, Martin F. Haslanger
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Patent number: 4416896Abstract: 7-Oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.Type: GrantFiled: May 17, 1982Date of Patent: November 22, 1983Assignee: E. R. Squibb & Sons, Inc.Inventors: Masami Nakane, David L. Snitman, Joyce Reid, Martin F. Haslanger
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Patent number: 4317910Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein n is 1 or 2; m is 2, 3 or 4; and R.sub.2 is a tertiary amino group; are intermediates useful in the preparation of compounds having hypotensive activity.Type: GrantFiled: August 14, 1978Date of Patent: March 2, 1982Assignee: E. R. Squibb & Sons, Inc.Inventors: Frederic P. Hauck, Joyce Reid
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Patent number: 4173640Abstract: Compounds are provided having the structure ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 or R.sub.4 is hydrogen or acyl and R.sub.5 is hydrogen or acyl, X is a straight or branched bivalent alkylene radical and Y is ##STR2## These compounds are useful in the treatment of hypertension.Type: GrantFiled: August 4, 1977Date of Patent: November 6, 1979Assignee: E. R. Squibb & Sons, Inc.Inventors: Frederic P. Hauck, Michael E. Condon, Joyce Reid
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Patent number: 4172945Abstract: Compounds are provided having the structure ##STR1## wherein n is 1, 2 or 3, m is 0, 1 or 2, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be the same or different and can be hydrogen, lower alkyl, halo-lower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.Type: GrantFiled: July 27, 1978Date of Patent: October 30, 1979Assignee: E. R. Squibb & Sons, Inc.Inventors: Frederic P. Hauck, Joseph E. Sundeen, Joyce Reid
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Patent number: 4166183Abstract: Compounds having the formula ##STR1## wherein R.sub.1 is alkanoyl; and one of R.sub.2, R.sub.3 and R.sub.4 is ##STR2## wherein R.sub.5 is alkyl, and the other groups are --CH.sub.2 --; have useful hypotensive activity.Type: GrantFiled: March 23, 1978Date of Patent: August 28, 1979Assignee: E. R. Squibb & Sons, Inc.Inventors: Frederic P. Hauck, Joyce Reid
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Patent number: 4156723Abstract: Compounds are provided having the structure ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 or R.sub.4 is hydrogen or acyl, and R.sub.5 is hydrogen or acyl, X is a straight or branched bivalent alkylene radical and Y is ##STR2## These compounds are useful in the treatment of hypertension.Type: GrantFiled: August 4, 1977Date of Patent: May 29, 1979Assignee: E. R. Squibb & Sons, Inc.Inventors: Frederic P. Hauck, Michael E. Condon, Joyce Reid
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Patent number: 4138497Abstract: Compounds are provided having the structure ##STR1## wherein n is 1, 2 or 3, m is 0, 1 or 2, R.sub.1 R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be the same or different and can be hydrogen, lower alkyl, halo-lower alkyl, acyl, lower alkoxy-carbonyl ##STR2## amido ##STR3## or lower alkoxylakylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR4## These compounds are useful in the treatment of hypertension.Type: GrantFiled: July 29, 1977Date of Patent: February 6, 1979Assignee: E. R. Squibb & Sons, Inc.Inventors: Frederic P. Hauck, Joseph E. Sundeen, Joyce Reid
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Patent number: 4127578Abstract: Diene intermediates for indantetrols are provided having the structure ##STR1## wherein X is a single bond or a straight or branched chain alkylene group containing from 1 to 10 carbons, Y is ##STR2## wherein R.sub.7 is hydrogen, lower alkyl, arylalkyl or lower alkoxy and ##STR3## is taken together to form a piperidyl or pyrrolidyl radical, R.sub.8 and R'.sub.8 are lower alkyl or monocyclic cycloalkyl, n is 1 to 3, m and m' are 0, 1 or 2.Type: GrantFiled: September 12, 1977Date of Patent: November 28, 1978Assignee: E. R. Squibb & Sons, Inc.Inventors: Frederic P. Hauck, Joyce Reid, Venkatachala L. Narayanan, Christopher M. Cimarusti, Rudiger D. Haugwitz, Joseph E. Sundeen
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Patent number: 4127717Abstract: Compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein n is 1 or 2; m is 2, 3 or 4; R.sub.1 is alkanoyl; and R.sub.2 is a tertiary amino group; have hypotensive activity.Type: GrantFiled: March 20, 1978Date of Patent: November 28, 1978Assignee: E. R. Squibb & Sons, Inc.Inventors: Frederic P. Hauck, Joyce Reid
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Patent number: 4103095Abstract: Compounds having the structure ##STR1## wherein R.sub.1 is alkyl or arylalkyl; R.sub.2 is --C.tbd.N, --C.tbd.CH or ##STR2## wherein R.sub.4 is hydrogen, alkyl, aryl, or arylalkyl; R.sub.3 is alkanoyl; m is 1, 2, 3, or 4; n is 1, 2, or 3; and p is 0, 1, 2 or 3; are useful for the treatment of hypertension.Type: GrantFiled: July 5, 1977Date of Patent: July 25, 1978Assignee: E. R. Squibb & Sons, Inc.Inventors: Frederic P. Hauck, Joyce Reid
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Patent number: 4092318Abstract: Compounds are provided having the structure ##STR1## WHEREIN N IS 1, 2 OR 3, M AND M' ARE 0, 1 OR 2, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be the same or different and can be hydrogen, lower alkyl, halolower alkyl, acyl, lower alkoxy-carbonyl ##STR2## or lower alkoxyalkylene, X is a straight or branched bivalent aliphatic radical and Y is ##STR3## These compounds are useful in the treatment of hypertension.Type: GrantFiled: March 15, 1976Date of Patent: May 30, 1978Assignee: E. R. Squibb & Sons, Inc.Inventors: Frederic Peter Hauck, Joyce Reid, Venkatachala L. Narayanan, Christopher M. Cimarusti, Rudiger D. Haugwitz, Joseph E. Sundeen
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Patent number: 4081444Abstract: Compounds having the structure ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sub.1 is hydrogen, ##STR2## wherein X is alkyl or aryl, or ##STR3## wherein Y is alkyl or aryl; R.sub.2 is hydrogen, halogen, alkyl, hydroxy, alkoxy or ##STR4## R.sub.3 is hydrogen, halogen, alkyl, alkoxy, alkylthio, trifluoromethyl, or nitro; and n is 1, 2, or 3, have useful pharamacological properties.Type: GrantFiled: January 21, 1977Date of Patent: March 28, 1978Assignee: E. R. Squibb & Sons, Inc.Inventors: Michael E. Condon, Frederic P. Hauck, Joyce Reid