Patents by Inventor Joyce Running

Joyce Running has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5747244
    Abstract: Nucleic acid probes are immobilized on polystyrene surfaces such as the wells of microtiter plates for use in solution phase nucleic acid sandwich hybridization assays, particularly those using large branched DNA amplification multimers, by: (a) cleansing the surface by washing it sequentially with a strong acid, a strong base, and water, (b) passively adsorbing a polypeptide having primary amino groups onto the cleansed surface, and (c) covalently bonding the probe to the adsorbed polypeptide via a base-stable bifunctional crosslinking agent, and (d) subjecting the surface to conditions that simulate the hybridization conditions used in the assay.
    Type: Grant
    Filed: December 23, 1991
    Date of Patent: May 5, 1998
    Assignee: Chiron Corporation
    Inventors: Patrick Sheridan, Chu-An Chang, Joyce Running, Michael S. Urdea
  • Patent number: 5712383
    Abstract: Nucleic acid probes are immobilized on polystyrene surfaces such as the wells of microtiter plates for use in solution phase nucleic acid sandwich hybridization assays, particularly those using large branched DNA amplification multimers, by: (a) cleansing the surface by washing it sequentially with a strong acid, a strong base, and water, (b) passively adsorbing a polypeptide having primary amino groups onto the cleansed surface, and (c) covalently bonding the probe to the adsorbed polypeptide via a base-stable bifunctional crosslinking agent, and (d) subjecting the surface to conditions that simulate the hybridization conditions used in the assay.
    Type: Grant
    Filed: May 10, 1995
    Date of Patent: January 27, 1998
    Assignee: Chiron Corporation
    Inventors: Patrick Sheridan, Chu-An Chang, Joyce Running, Michael S. Urdea