Abstract: A thermal management system for an aircraft includes a first gas turbine engine, first thermal bus, first heat exchanger, one or more first ancillary systems, vapour compression system, one or more second ancillary systems and second heat exchanger. A waste heat energy generated by a first gas turbine engine, and a first ancillary system, transfers to the first heat transfer fluid. A waste heat energy generated by a second ancillary system transfers to a second heat transfer fluid, and the second heat exchanger transfers the waste heat energy from the second heat transfer fluid to the first heat transfer fluid. The waste heat energy generated by a second ancillary system transfers to the first heat transfer fluid, and the first heat exchanger transfers the waste heat energy to a dissipation medium. The waste heat energy transferred to the second heat transfer fluid ranges from 20 kW to 300 kW.

Abstract: Various systems, device and automated processes allow video streaming hosts or other server devices to publish their internal/local addresses (e.g., addresses used on a subnet or other local area network) to a backend address server operating on a wide area network (WAN) such as the Internet. Client devices attempting to subsequently contact server devices operating in the same local network can contact the address to obtain the internal address of the target server, thereby allowing direct LAN connections between clients and servers.

Abstract: The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention provides engineered sucrose synthase (SuS) enzymes, polypeptides having SuS activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the GT enzymes and methods of using the engineered GT enzymes to make products with ?-glucose linkages. The present invention further provides compositions and methods for the production of rebaudiosides (e.g., rebaudioside M, rebaudioside A, rebaudioside I, and rebaudioside D). The present invention also provides compositions comprising the SuS enzymes and methods of using them. Methods for producing GT and SuS enzymes are also provided.

Abstract: A biodegradable bi-component fiber may include a polyhydroxyalkanoate and/or polylactic acid with cellulose acetate and/or plasticized cellulose acetate for use in a filter material configured for use in a filter of a smoking article. The bi-component fiber may have a sheath-core construction where one component of the bi-component forms the core, and the other component forms the sheath of each fiber. A filter made in accordance with this design may also include non-biodegradable material.

Abstract: A folding toy theatre with characters that move using just one finger, comprising a theatre surround with side flaps which fold backwards allowing it to stand upright, the front face has a cut central aperture and a slot cut out at its bottom face edge. The characters have a long forward flap from the base of the body to action it and two flaps at the left and right sides of the body which fold backwards to keep the character upright. The character is placed inside the theatre surround the long forward flap passes through the bottom face slot of the theatre surround so the character can be moved from the front of the theatre. The theatre surround can have slots in its side flaps, a tabbed background can be added or the side flaps have a slot and latch to join directly.

Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.

Abstract: A document management system uses machine learning to identify legal obligations within contract documents. The document management system trains a machine-learned model using historical contract documents having historical legal obligations; the trained machine-learned model is configured to identify portions of text within a contract document that correspond to legal obligations. The machine-learned model, applied to a set of contract documents, identifies a set of legal obligations. The document management system presents, via a user interface, information about the set of identified legal obligations.

Abstract: Systems and methods for targeted advertising to specific consumers are disclosed. A system may include a memory storing instructions; and at least one processor configured to execute the instructions to: receive, over a network, consumer data from a client device; identify a plurality of client-provided consumers from the consumer data; obtain a plurality of unique consumer identifiers corresponding to the plurality of client-provided consumers; and identify at least one first overlapping unique consumer identifier by matching at least one of the plurality of client-provided consumers with at least one publisher-provided consumer provided by a first publisher device of a plurality of publisher devices, the first publisher device having a highest priority among the plurality of publisher devices.

Abstract: A method of operating a surgical stapler includes advancing a knife assembly at a first velocity until a predetermined force is detected, advancing the knife assembly at a second velocity when the predetermined force is detected, the second velocity being less than the first velocity, and continuing to advance the knife assembly at the second velocity until the knife assembly travels a cutting stroke distance.

Abstract: Disclosed herein are systems and methods for eardrum acoustic pressure estimation for hearing device applications. A receiver signal is produced through a receiver of a hearing device, or a physical extension of the receiver, placed inside an ear canal of a user. A microphone signal is sensed, in response to the receiver signal, using a microphone placed outside the ear canal. Based on the receiver signal and the microphone signal, a reliability signal of the microphone signal and a feedback-path signal are computed. A spectral representation signal of the feedback-path signal is computed, and a real-ear response signal is computed using a mathematical combination of the spectral-representation signal and the reliability signal. The computed real-ear response signal is used to modify an operational characteristic of the hearing device, or to make a recommendation for modification of an operational characteristic or a physical characteristic of the hearing device.

Abstract: A surface mount device having features on contacts to prevent the surface mount device from tombstoning. The feature may be channel defined by the contact that helps balance a torque/force applied on each side of the surface mount device during a reflow soldering process. The feature may also be a solder mask that helps balance a torque/force applied on each side of the surface mount device during a reflow soldering process.

Abstract: A non-reciprocal phase shift device may include an optical waveguide (e.g., a silicon waveguide) on a substrate; and a magneto-optical cladding layer on the optical waveguide, wherein the magneto-optical cladding layer includes a plurality of segments arranged having alternating magnetization directions aligned transverse to a longitudinal direction of the optical waveguide.

Abstract: A container assembly for securing one or more bottles that includes an outer box and an insert. The outer box includes a bottom portion, a top pivotably connected to the first wall of the bottom portion and a securing portion pivotably connected to one of the second, third or fourth walls. The securing portion includes a neck slot that is configured to receive the neck of the bottle when the securing portion is in the securing position. The insert includes an upper retainer portion having a neck retaining slot defined therein, a main panel and a lower retainer portion. The neck retaining slot or tunnel in the upper retainer portion is configured to receive the neck of the bottle. The lower retainer portion has a bottom retaining opening defined therein. The main panel extends between the upper and lower retainer portions.

Abstract: A reusable apparatus for storing and delivering a sterile product. The apparatus includes a compressible reservoir adapted to allow for filling, storing, and delivering the sterile product, and a sterile inlet and outlet device including an inlet portion and an outlet portion. The sterile inlet and outlet device is connected to the compressible reservoir and adapted to allow the sterile product to be filled from exterior to the reusable apparatus and into the compressible reservoir through the inlet portion and adapted to allow the sterile product to be delivered from the compressible reservoir through the outlet portion.

Abstract: A biodegradable bi-component fiber may include a polyhydroxyalkanoate and/or polylactic acid with cellulose acetate and/or plasticized cellulose acetate for use in a filter material configured for use in a filter of a smoking article. The bi-component fiber may have a sheath-core construction where one component of the bi-component forms the core, and the other component forms the sheath of each fiber. A filter made in accordance with this design may also include non-biodegradable material.

Abstract: The present invention provides antibodies and antigen-binding fragments thereof that bind to ILT4 (immunoglobulin-like transcript 4) and combinations thereof, e.g., with an anti-PD1 antibody. Also provided are methods of use thereof, for example, for treating or preventing cancer in a subject; and methods of making such antibodies and fragments.

Abstract: Systems, methods, and devices are described for enabling a user to import a library into a computer program under development. The library includes a data storage interface, one or more semantic objects, and one or more data manipulation or data analysis operations. A user is able to reference code of the library within the computer program under development to generate a dataset from data obtained via the data storage interface and associate the one or more semantic objects with the dataset to generate a semantically-annotated dataset. Systems, methods, and devices enable, based on the importing: the user to invoke a semantic-guided operation of the library that utilizes the semantically-annotated dataset to infer an aspect of a data manipulation or data analysis operation to be performed on the semantically-annotated dataset; or the suggestion of a data manipulation or data analysis operation to the user based on the semantically-annotated dataset.

Abstract: The present invention relates generally to a portable coring machine for penetrating a surface to install or repair sub-surface structures. Coring machine may include a frame assembly and a drilling device. Frame assembly may include a plurality of interconnected bars and facilitate operating drilling device in a generally horizontal position or in a generally vertical position. Further, frame assembly may accommodate core bits of different sizes for cutting an annular hole into asphalt, concrete or other hard surface. Support members of frame assembly may be configured to support a track including a plurality of teeth. The track may engage with a gear assembly of a mounting block configured to support the drilling device. Advantageously, coring machine may be moveable along track in response to an operator rotating a crank mechanically coupled to the gear assembly.

Abstract: The present invention provides antibodies and antigen-binding fragments thereof that bind to ILT4 (immunoglobulin-like transcript 4) and combinations thereof, e.g., with an anti-PD1 antibody. Also provided are methods of use thereof, for example, for treating or preventing cancer in a subject; and methods of making such antibodies and fragments.