Abstract: The present disclosure is directed generally to systems and methods for relieving dyspnea. A method in accordance with a particular embodiment includes receiving an input signal from a patient sensor, the input signal corresponding to an indication of the patient's breathing. The method can further include, based at least in part on the input signal, at least reducing the patient's sensation of dyspnea by delivering electrical stimulation to at least one electrode, the at least one electrode being positioned in signal communication with at least one of the patient's inspiratory muscles, expiratory muscles, afferent neural pathways of the inspiratory muscles, and afferent neural pathways of the expiratory muscles.