Abstract: The present invention provides a sustained drug release system comprising IL-2 and anti-IL-2 incorporated into a thermosensitive hydrogel that is engineered to be in liquid form at low temperatures for delivery, but form a hydrogel at physiological body temperatures to act as a sustained release platform. The thermostable hydrogel solution slowly releases IL-2 and anti-IL-2 to provide optimal concentrations for effective treatment of autoimmune diseases.

Abstract: The present disclosure provides a device for determining the presence of BNP, proBNP and NT-proBNP. The devices comprise multiple capture regions configured to selectively capture BNP, proBNP and NT-proBNP by specific binding of proBNP. Alternatively or additionally, the devices may capture and label epitopes to distinguish proBNP from NT-proBNP or BNP.

Abstract: The present disclosure provides a sensor assembly for measuring a property of a sample. The sensing assembly comprises first and second dielectric layers. The first dielectric layer provides a well or aperture which is associated with an electrode. The second dielectric layer is provided on the first dielectric layer and provides an aperture fluidly connected to the well or aperture in the first dielectric layer.

Abstract: The present disclosure provides methods and systems for reducing interference by one or more bubbles in a sensing assembly. Bubble prevention arrangements can use surfaces located in a fluid channel to provide surfaces with higher affinity for bubbles relative to the other surfaces so that the surface retains one or more bubbles within a bubble collection region; and/or to divert at least a portion of any bubbles passing through an opening in the fluid channel. Additionally or alternatively, bubble prevention arrangements comprise an agitation device configured to agitate liquid within the fluid channel. Additionally or alternatively, bubble prevention arrangements are configured to displace one or more bubbles in a region on or adjacent the sensing surface so as to reduce interference of one or more bubbles on the sensing surface.

Abstract: The present disclosure provides methods and systems for reducing interference by one or more bubbles in a sensing assembly by determining a first property of the solution and using the first property in a removal step.

Abstract: The present disclosure provides a sensor assembly for a target analyte. The sensor assembly comprises plural sensing sites, each of the sensing sites comprising one or more through holes. Each of the sensing sites has a different through hole configuration corresponding to a different property of the one or more through holes.

Abstract: The present disclosure provides sensor assemblies comprising a plurality of mixing species provided adjacent or on the sensing surface, wherein each mixing species comprises a polynucleotide chain and wherein each mixing species is anchored to the sensor assembly; and an actuation unit configured to move at least a part of each mixing species in a plurality of directions. Alternatively or additionally, the polynucleotide chain comprises DNA and has a length of at least 10 nm.

Abstract: The present disclosure provides a sensing assembly for sensing an analyte. The sensing assembly comprises multiple test electrodes configured to provide signals from multiple independent measurements in response to the analyte. Alternatively or additionally, the multiple test electrodes are configured to produce different transient responses in response to a given concentration of the analyte.

Abstract: A sample testing device is disclosed. The sample testing device can include a first compartment that is configured to receive a test sample, a second compartment that is configured to receive the test sample, a separator that is disposed between and separating the first compartment and the second compartment, and a mechanical lock structure that is configured to lock and unlock a movement of the separator. When the mechanical lock is unlocked, the separator opens to transfer the test sample from the first compartment to the second compartment. The sample testing device can include a sensing assembly.

Abstract: A sensor assembly for sensing an analyte in a sample matrix comprises an electrode assembly comprising a set of at least one test electrode and may also comprise one or more control electrodes and/or an applicator assembly. The electrode assembly is configured or configurable to define one or more active test electrodes of the set of one or more test electrodes, and at least one of the electrode assembly and the applicator assembly is or are configured or configurable to adjust a quantity of the analyte provided to the active electrode(s), per unit time, for said interaction based at least in part on an analyte characteristic. Alternatively or additionally, the electrode assembly is configured and arranged in a flow path such that the amounts of sample matrix provided to the test electrode(s) and control electrode(s) of the electrode assembly are substantially equal.

Abstract: A method of verifying proper functionalization of a sensor and a negative test result obtained by exposing a sensing element functionalized to detect a target analyte to a test sample is described. The method may include, subsequent to or simultaneously with the exposing the sensing element to the test sample, exposing the sensing element to a test confirmation sample, the test confirmation sample comprising at least one of the target analyte in an amount greater than a detection limit of the sensing element and a recombinant protein of the target analyte in an amount greater than a detection limit of the sensing element and performing a measurement using the sensing element to obtain a subsequent test result.

Abstract: One embodiment is a multi-analyte molecular sensing system designed for implantation in a body of a subject, the sensing system including an implant comprising a flexible substrate having a plurality of electronics systems disposed thereon; a sensor array comprising multiple sensors disposed on the flexible substrate; a sensor protection mechanism for providing selective protection and exposure of one or more of the sensors; a power system for providing power to the electronics systems; a data communication system for communicating with one or more external devices; and a biocompatible housing for protecting the implant.

Abstract: Techniques relating to scrolling, object selection, and object moving are discussed. Strokes are inputted by a user, for instance using a touch sensitive surface. Strokes are directed to a scrollable surface with objects therein. Strokes that end before meeting a condition select the objects, and strokes then end after meeting the condition move the objects or representations thereof. The condition may be a distance. Selection may only occur when strokes meet a threshold condition such as having a particular direction (e.g., perpendicular to a direction for scrolling the surface) or moving a minimal distance. Strokes in a scrolling direction (e.g., horizontal) may scroll the surface in that direction and strokes in another direction (e.g., vertical) may both select and move the objects. Objects selected may slide on rails before moving.

Abstract: Embodiments relate to a computing device having storage, a processor, a display, a first human input device, and a second human input device, where the first human input device is in a first category of human input devices and the second human input device is in a second category of human input devices. The computing device may perform a process involving executing a windowing environment that manages windows of applications executing on the computing device. The windowing environment may receive raw inputs from the first and second human input devices and in turn generate input pointers for the raw inputs, respectively. The input pointers may be or include instances of an input pointer class implemented by the windowing environment, the pointer class used by the windowing environment for arbitrary different types of human input pointer devices including the first human input device and the second human input device.

Abstract: A method for rapidly creating an indoor wireless signal fingerprint database, comprising the following steps: constructing an indoor and outdoor combined three-dimensional scene model of a target building, predicting wireless signal field intensity information of 3D space using a ray-tracing algorithm, selecting a small quantity of testing points to perform manual field measurements and recording the wireless signal intensity information, correcting/calibrating 3D ray-tracing propagation model parameters based on the difference between the actually measured wireless signal intensity information and the theoretical wireless signal intensity information calculated through the 3D ray-tracing propagation model.

Abstract: Method of positioning blind coverage regions in an indoor wireless network. The method comprises the following steps: constructing an indoor and outdoor combined three-dimensional spatial structural model of a target scene; recording and storing information of wireless access equipment which can be received by the target scene, both from the indoor wireless network and from an outdoor (e.g., cellular) network with overlapping coverage; establishing a wireless fingerprint database of the target building covering both the indoor and the outdoor wireless networks; when loss of coverage is detected, the UE handing over to the outdoor network to transmit a measurement report from which the outdoor network can derive the UE's position (e.g.

Abstract: This disclosure provides systems, methods, and apparatus for display elements configured for rotational movement. A display element can include a light modulator and a first electrostatic actuator configured to induce rotational movement of the light modulator in a plane parallel to a substrate over which the display element is manufactured. A first anchor can be coupled to the substrate and positioned adjacent to a proximal end of the light modulator. A first drive beam electrode can be coupled to a second anchor. A first load beam electrode can be coupled at a first end to the first anchor and coupled at a second end to a first edge of the light modulator at a point closer to a distal end of the light modulator than to the proximal end of the light modulator.

Abstract: Embodiments relate to a computing device having storage, a processor, a display, a first human input device, and a second human input device, where the first human input device is in a first category of human input devices and the second human input device is in a second category of human input devices. The computing device may perform a process involving executing a windowing environment that manages windows of applications executing on the computing device. The windowing environment may receive raw inputs from the first and second human input devices and in turn generate input pointers for the raw inputs, respectively. The input pointers may be or include instances of an input pointer class implemented by the windowing environment, the pointer class used by the windowing environment for arbitrary different types of human input pointer devices including the first human input device and the second human input device.

Abstract: Method of positioning blind coverage regions in an indoor wireless network. The method comprises the following steps: constructing an indoor and outdoor combined three-dimensional spatial structural model of a target scene; recording and storing information of wireless access equipment which can be received by the target scene, both from the indoor wireless network and from an outdoor (e.g., cellular) network with overlapping coverage; establishing a wireless fingerprint database of the target building covering both the indoor and the outdoor wireless networks; when loss of coverage is detected, the UE handing over to the outdoor network to transmit a measurement report from which the outdoor network can derive the UE's position (e.g.

Abstract: A method for rapidly creating an indoor wireless signal fingerprint database, comprising the following steps: constructing an indoor and outdoor combined three-dimensional scene model of a target building, predicting wireless signal field intensity information of 3D space using a ray-tracing algorithm, selecting a small quantity of testing points to perform manual field measurements and recording the wireless signal intensity information, correcting/calibrating 3D ray-tracing propagation model parameters based on the difference between the actually measured wireless signal intensity information and the theoretical wireless signal intensity information calculated through the 3D ray-tracing propagation model.