Patents by Inventor Joze Gnidovec

Joze Gnidovec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isopropanol water solvate of olanzapine
    Patent number: 7906642
    Abstract: The invention relates to a novel and well defined Oolvate form of olanzapine which contains 2 molecules of water and 1 molecule of isopropanol per 2 molecules of olanzapine, and which can be converted into other, forms of olanzapine, in particular form (I) of olanzapine, as well as processes for preparing form (I) olanzapine.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: March 15, 2011
    Assignee: KRKA, Tovarna Zdravil, D.D.
    Inventors: Berta Kotar-Jordan, Roman Lenarsic, Marija Grcman, Matej Smrkolj, Anton Meden, Igor Simonic, Rok Zupet, Joze Gnidovec, Primoz Benkic
  • PROCESS FOR THE SYNTHESIS OF INTERMEDIATES OF CHLORAMPHENICOL OR ITS ANALOGUES
    Publication number: 20090149657
    Abstract: The present invention relates to the synthesis of antibacterial compounds such as Chloramphenicol and its analogues Thiamphenicol and Florfenicol and particularly to a new reaction for the preparation of the intermediate compound aminodiolphenylsulfone. This reaction permits the introduction of modified residues to obtain modified antibiotics with an improved stability towards the action of bacterial resistant determinants. In addition, higher purities may be also obtained due to an improved procedure requiring fewer purification steps.
    Type: Application
    Filed: August 25, 2006
    Publication date: June 11, 2009
    Applicant: KRKA
    Inventors: Joze Gnidovec, Ivanka Kolenc
  • Isopropanol water solvate of olanzapine
    Publication number: 20070191348
    Abstract: The invention relates to a novel and well defined Oolvate form of olanzapine which contains 2 molecules of water and 1 molecule of isopropanol per 2 molecules of olanzapine, and which can be converted into other, forms of olanzapine, in particular form (I) of olanzapine, as well as processes for preparing form (I) olanzapine.
    Type: Application
    Filed: March 7, 2005
    Publication date: August 16, 2007
    Applicant: KRKA, Tovarna Zdravil, D.D.
    Inventors: Berta Kotar-Jordan, Roman Lenarsic, Marija Grcman, Matej Smrkolj, Anton Meden, Igor Simonic, Rok Zupet, Joze Gnidovec, Primoz Benkic
  • Process for preparing 9-(2-hydroxyethoxymethyl)-guanine
    Patent number: 4826981
    Abstract: There is disclosed a process for preparing 9-(2-hydroxyethoxymethyl)-guanine (acyclovir) of the formula IV ##STR1## wherein a novel compound of the formula I ##STR2## wherein R and R' may be the same or different and represent hydrogen, (C.sub.1 -C.sub.8)acyl or benzyl and R.sub.1 represents (C.sub.1 -C.sub.8)acyl, is hydrolyzed basic conditions. Also disclosed is the novel compound of the formula I, a process for the preparation thereof by condensing a novel compound of the formula II ##STR3## with a compound A--CH.sub.2 --O--CH.sub.2 CH.sub.
    Type: Grant
    Filed: October 19, 1987
    Date of Patent: May 2, 1989
    Assignee: KRKA
    Inventors: Joze Kobe, Joze Gnidovec, Pavle Zupet
  • Process for preparing 9-(2-hydroxyethoxymethyl)-guanine, and intermediates useful in said process
    Patent number: 4701526
    Abstract: There is disclosed a process for preparing 9-(2-hydroxyethoxymethyl)-guanine (acyclovir) of the formula IV ##STR1## wherein a novel compound of the formula I ##STR2## wherein R and R' may be the same or different and represent hydrogen, (C.sub.1 -C.sub.8)acyl or benzyl and R.sub.1 represents (C.sub.1 -C.sub.8)acyl, is hydrolyzed under mild basic conditions. Also disclosed is the novel compound of the formula I, a process for the preparation thereof by condensing a novel compound of the formula II ##STR3## with a compound A--CH.sub.2 --O--CH.sub.2 CH.sub.
    Type: Grant
    Filed: December 11, 1985
    Date of Patent: October 20, 1987
    Assignee: KRKA, tovarna zdravil, n.sol.o.
    Inventors: Joze Kobe, Joze Gnidovec, Pavle Zupet