Abstract: The embodiments of the present disclosure provide a method for producing Ac-225 from Ra-226, comprising submitting Ra-226 to a photo-nuclear process, collecting an electrochemical precipitation of an Ac-225 on a cathode in a recipient, removing the cathode from the recipient after the electrochemical precipitation of the Ac-225, transferring the cathode to a hot cell environment, and extracting the Ac-225 from the cathode in the hot cell environment. The Ra-226 may comprise a liquid solution in the recipient, and submitting Ra-226 to the photo-nuclear process may comprise irradiating the Ra-226 to produce Ra-225. The Ra-225 may decay into Ac-225 upon irradiation of the Ra-226.

Abstract: A capsule for the transfer of a target material in a conveying system between a target irradiation station and a collecting station comprising: a beamline channel for the passage of an energetic beam irradiating the target material, a target holder holding the target material or a substrate backing the target material at a glancing angle with respect to the beamline channel axis, a degrader foil positioned across the beamline channel for degrading an energy of the energetic beam upstream of the target material, a target cooling inlet and a target cooling outlet for passage of a cooling fluid in a target cooling duct in a vicinity of the target holder such that the target material can be cooled during an irradiation, and a degrader foil cooling inlet and a degrader foil cooling outlet for passage of a cooling gas in a vicinity of the degrader foil.

Abstract: The embodiments of the present disclosure provide a method for producing Ac-225 from Ra-226, comprising submitting Ra-226 to a photo-nuclear process, collecting an electrochemical precipitation of an Ac-225 on a cathode in a recipient, removing the cathode from the recipient after the electrochemical precipitation of the Ac-225, transferring the cathode to a hot cell environment, and extracting the Ac-225 from the cathode in the hot cell environment. The Ra-226 may comprise a liquid solution in the recipient, and submitting Ra-226 to the photo-nuclear process may comprise irradiating the Ra-226 to produce Ra-225. The Ra-225 may decay into Ac-225 upon irradiation of the Ra-226.

Abstract: The present disclosure relates to an apparatus for the synthesis of chemical compounds, e.g., radiopharmaceutical compounds. In one implementation, the apparatus may include a synthesis module and a loading module configured to receive multiple chemical cassettes having reagents and a transfer mechanism. The apparatus may further include a shifter configured to move the cassettes from a location on the loading module to a location connected to the synthesis module on an interface configured to connect to the cassette.

Abstract: A capsule for the transfer of a target material in a conveying system between a target irradiation station and a collecting station comprising: a beamline channel for the passage of an energetic beam irradiating the target material, a target holder holding the target material or a substrate backing the target material at a glancing angle with respect to the beamline channel axis, a degrader foil positioned across the beamline channel for degrading an energy of the energetic beam upstream of the target material, a target cooling inlet and a target cooling outlet for passage of a cooling fluid in a target cooling duct in a vicinity of the target holder such that the target material can be cooled during an irradiation, and a degrader foil cooling inlet and a degrader foil cooling outlet for passage of a cooling gas in a vicinity of the degrader foil.

Abstract: The present disclosure relates to an apparatus for the synthesis of chemical compounds, e.g., radiopharmaceutical compounds. In one implementation, the apparatus may include a synthesis module and a loading module configured to receive multiple chemical cassettes having reagents and a transfer mechanism. The apparatus may further include a shifter configured to move the cassettes from a location on the loading module to a location connected to the synthesis module on an interface configured to connect to the cassette.

Abstract: The present invention is related to a device and a method for producing a radioisotope of interest from a target fluid irradiated with a beam of accelerated charged particles, the device includes in a circulation circuit (17): an irradiation cell (1) having a metallic insert (2) able to form a cavity (8) designed to house the target fluid and closed by an irradiation window (7), the cavity (8) including at least one inlet (4) and at least one outlet (5); a pump (16) for circulating the target fluid inside the circulation circuit (17); an external heat exchanger (15); the pump (16) and the external heat exchanger (15) forming external cooling means of the target fluid; the device means for pressurizing (14) of the circulation circuit (17) and the external cooling means of the target fluid are arranged in such a way that the target fluid remains inside the cavity (8) essentially in the liquid state during the irradiation.

Abstract: The present invention is related to a device and a method for producing a radioisotope of interest from a target fluid irradiated with a beam of accelerated charged particles, the device includes in a circulation circuit (17): an irradiation cell (1) having a metallic insert (2) able to form a cavity (8) designed to house the target fluid and closed by an irradiation window (7), the cavity (8) including at least one inlet (4) and at least one outlet (5); a pump (16) for circulating the target fluid inside the circulation circuit (17); an external heat exchanger (15); the pump (16) and the external heat exchanger (15) forming external cooling means of the target fluid; the device means for pressurizing (14) of the circulation circuit (17) and the external cooling means of the target fluid are arranged in such a way that the target fluid remains inside the cavity (8) essentially in the liquid state during the irradiation.