Abstract: The present disclosure relates to the fields of packaging, transportation, and storage of temperature-sensitive materials, such as biological and/or pharmaceutical products. Various aspects of such packaging, transportation, and storage are provided herein for ultra-low temperature materials useful for the treatment and/or prevention of disease. The present disclosure also provides packaging materials, methods of transportation, and methods of storage for maintaining biological and/or pharmaceutical materials at ultra-low temperatures in order to maintain the integrity of the materials. The present disclosure further relates to the field of RNA to prevent or treat coronavirus infection.

Abstract: Actual capacity usage limits for one or more logical partitions or groups of logical partitions are managed based on hardware-specific determinations of actual capacity usage.

Abstract: A system and method for managing mainframe computer system billable usage includes determining gross mainframe computer system capacity usage for billable mainframe computer system workload, and identifying what of that workload is discount-qualifying mainframe computer system workload. Capacity usage specific to the discount-qualifying mainframe computer system workload is determined in order to determine a billable capacity usage specific to that workload, the determination being based on one or more applicable discount rates applicable thereto. A billable total mainframe computer system capacity usage for the billable mainframe computer system workload is then determined based on the billable capacity usage specific to the discount-qualifying mainframe computer system workload.

Abstract: The present invention relates to the fumarate salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile, pharmaceutical compositions comprising as active ingredient said salt and to processes for their preparation.

Abstract: In mainframe computer system, workload tasks are accomplished using a logically partitioned data processing system, where the partitioned data processing system is divided into multiple logical partitions. In a system and method managing such a computer system, each running workload tasks that can be classified based on time criticality, and groups of logical partitions can be freely defined. Processing capacity limits for the logical partitions in a group of logical partitions based upon defined processing capacity thresholds and upon an iterative determination of how much capacity is needed for time critical workload tasks. Workload can be balanced between logical partitions within a group, to prevent surplus processing capacity being used to run not time critical workload on one logical partition when another logical partition running only time critical workload tasks faces processing deficit.

Abstract: In a system and method for managing mainframe computer usage, preferred values for service class defined performance goals are determined to optimize workload performance in service classes across a logical partition. A method for managing mainframe computer system usage can include receiving a performance optimization goal for workload performance in a service class, the service class having a defined performance goal. Achievement of the performance optimization goal is assessed, and a preferred value for the defined performance goal is determined based on assessing achievement of the performance optimization goal. Workload criticality can be taken into account, and automatic changes to the performance goal authorized.

Abstract: The invention provides a heat conductor device (10) for removing heat from an electrical component (12) operating in a frequency range, the device comprising a body (13) having a first thermal conductivity, characterized in that the body (13) is provided with a heat spreader (14) comprising a pattern of thermally conducting tiles (20, 50, 51, 52, 61) separated by gaps (21), the tiles having a second thermal conductivity higher than the first thermal conductivity, wherein each tile has at most a maximum area value and the gaps have at least a minimum gap width, and the maximum area and the minimum width are dimensioned for conforming to a predetermined electromagnetic interference characteristic of the heat conductor device when combined with the electrical component operating in the frequency range. The invention also provides a method for forming a heat conductor device.

Abstract: In a system and method for managing mainframe computer usage, preferred values for service class defined performance goals are determined to optimize workload performance in service classes across a logical partition. A method for managing mainframe computer system usage can include receiving a performance optimization goal for workload performance in a service class, the service class having a defined performance goal. Achievement of the performance optimization goal is assessed, and a preferred value for the defined performance goal is determined based on assessing achievement of the performance optimization goal. Workload criticality can be taken into account, and automatic changes to the performance goal authorized.

Abstract: The invention provides a novel pharmaceutical composition comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base characterized in that the acid respectively base:drug compound ratio is at least 1:1 by weight.

Abstract: The invention provides a heat conductor device (10) for removing heat from an electrical component (12) operating in a frequency range, the device comprising a body (13) having a first thermal conductivity, characterized in that the body (13) is provided with a heat spreader (14) comprising a pattern of thermally conducting tiles (20, 50, 51, 52, 61) separated by gaps (21), the tiles having a second thermal conductivity higher than the first thermal conductivity, wherein each tile has at most a maximum area value and the gaps have at least a minimum gap width, and the maximum area and the minimum width are dimensioned for conforming to a predetermined electromagnetic interference characteristic of the heat conductor device when combined with the electrical component operating in the frequency range. The invention also provides a method for forming a heat conductor device.

Abstract: In a system and method for managing mainframe computer usage, preferred values for service class defined performance goals are determined to optimize workload performance in service classes across a logical partition. A method for managing mainframe computer system usage can include receiving a performance optimization goal for workload performance in a service class, the service class having a defined performance goal. Achievement of the performance optimization goal is assessed, and a preferred value for the defined performance goal is determined based on assessing achievement of the performance optimization goal. Workload criticality can be taken into account, and automatic changes to the performance goal authorized.

Abstract: In mainframe computer system, workload tasks are accomplished using a logically partitioned data processing system, where the partitioned data processing system is divided into multiple logical partitions. In a system and method managing such a computer system, each running workload tasks that can be classified based on time criticality, and groups of logical partitions can be freely defined. Processing capacity limits for the logical partitions in a group of logical partitions based upon defined processing capacity thresholds and upon an iterative determination of how much capacity is needed for time critical workload tasks. Workload can be balanced between logical partitions within a group, to prevent surplus processing capacity being used to run not time critical workload on one logical partition when another logical partition running only time critical workload tasks faces processing deficit.

Abstract: In mainframe computer system, workload tasks are accomplished using a logically partitioned data processing system, where the partitioned data processing system is divided into multiple logical partitions. In a system and method managing such a computer system, each running workload tasks that can be classified based on time criticality, and groups of logical partitions can be freely defined. Processing capacity limits for the logical partitions in a group of logical partitions based upon defined processing capacity thresholds and upon an iterative determination of how much capacity is needed for time critical workload tasks. Workload can be balanced between logical partitions within a group, to prevent surplus processing capacity being used to run not time critical workload on one logical partition when another logical partition running only time critical workload tasks faces processing deficit.

Abstract: The present invention relates to a pharmaceutical composition comprising as active ingredient the hydrochloric acid salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile and to processes for their preparation.

Abstract: The present invention relates to the fumarate salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile, pharmaceutical compositions comprising as active ingredient said salt and to processes for their preparation.

Abstract: The present invention relates to a pharmaceutical composition comprising as active ingredient the hydrochloric acid salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile and to processes for their preparation.

Abstract: The present invention relates to a pharmaceutical composition comprising as active ingredient the hydrochloric acid salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethyl-phenyl]amino]-2-pyrimidinyl]amino]benzonitrile and to processes for their preparation.

Abstract: Fabric support and a weaving machine using the support, in which the fabric support (1) includes several supporting elements (10, 11, 12, 13, 14, 15, 16, 17, 18, 19) which can be arranged next to one another and a profiled section (20, 30, 40, 50, 60) which is supported by the supporting elements (10, 11, 12, 13, 14, 15, 16, 17 18, 19) and includes a guide surface (22) for a fabric (3).

Abstract: A valve (13a) is described comprising: a housing (50) having a fluid inlet for (54) receiving a flow of compressed fluid and a fluid outlet (55); a flow duct (60) movably mounted with respect to the housing, the duct (62) having a fluid inlet (62) for receiving a flow of compressed fluid and a fluid outlet (65), the fluid outlet being positioned around at least a part of the circumference of the duct and being dimensioned to provide a different flow rate at different sections or positions around the circumference of the duct; the fluid outlet of the housing being alignable with a portion of the fluid outlet of the duct to provide a flow rate related to the relative position of the portion of the fluid outlet of the duct and the fluid outlet of the housing; and, a drive element (70) for moving, e.g. rotating, the duct with respect to the housing such that a desired portion of the fluid outlet of the duct aligns with the fluid outlet of the housing. The valve may operate as a so-called throttle valve.

Abstract: In a bulk package system the stack of plates having a height Hplate is contacted and stabilized by an internal packaging structure with a height Hint which is higher than the stack to aid in protection of the plates from forces from above. A separate external packaging structure is provided with a height Hext being equal or larger than Hint. Forces acting upon the external packaging structure caused by e.g., collisions are not transferred to the stack of plates. The external packaging structure is assembled after the internal packaging structure.