Patents by Inventor Jozefus A.C. Smit

Jozefus A.C. Smit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9119794
    Abstract: The present invention pertains to a process for the preparation of a fast-disintegrating tablet (30) containing a medicinal substance, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element (100) having formed therein at least one cavity, (101) cooling the solid element (100) to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity (101) to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to a system for performing such a process and a package containing the resulting tablet.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: September 1, 2015
    Assignee: Intervet International B.V.
    Inventors: Hans Almer Middelbeek, Jozefus A. C. Smit
  • Patent number: 9095516
    Abstract: The present invention pertains to a process for the preparation of an orally disintegrating tablet for administration to a human subject, the tablet containing a medicinal substance to treat a disorder of the human subject, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element having formed therein at least one cavity, cooling the solid element to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity by extracting heat from the formulation through a cavity wall by conduction, to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity, and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to the tablet itself and a package comprising such a tablet.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: August 4, 2015
    Assignee: Intervet, Inc.
    Inventors: Hans Almer Middelbeek, Jozefus A. C. Smit, Jacobus Johannes Adriana Maria Verheezen
  • Patent number: 8961485
    Abstract: A method for fastening a thread (24) to a tampon (10), in particular a veterinary tampon, comprising the steps of passing the thread through the tampon by means of a needle (12, 14), and knotting the loose ends of the thread, wherein that the step of passing the thread through the tampon comprises: -piercing the tampon (10) with two hollow needles (12, 14), -inserting the distal ends of the needles into a mould (20) that forms a passage (16) interconnecting the open ends of the hollow needles, feeding the thread (24) to the proximal end of one (12) of the two needles, -applying a suction pressure to the proximal end of the other (14) of the two needles, -opening the mould (20), and -withdrawing the needles (12, 14) from the tampon (10).
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: February 24, 2015
    Assignee: Intervet International B.V.
    Inventors: Hans Almer Middelbeek, Jozefus A. C. Smit
  • Patent number: 8763446
    Abstract: A tube weld seam test method and device for testing a tube weld seam (32) of a flexible tube (18) for leaks having: a first pinching device (10) and a second pinching device (12) for pinching closed the flexible tube (18) at a first position (A) and at a second position (B), the weld seam to be tested being arranged between the first and second positions (A; B); a compressing mechanism arranged for partly compressing a tube section enclosed between the first and second pinching devices (10; 12); and a pressure test device (14) arranged for testing an internal pressure of said tube section in order to test the tube weld seam for leaks.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: July 1, 2014
    Assignee: Intervet International B.V.
    Inventors: Hans Almer Middelbeek, Jozefus A. C. Smit
  • Publication number: 20120289935
    Abstract: A tool for manipulating a solid object (12) in a cavity (16) of a human or animal body, comprising a longitudinal rod member (14) adapted for insertion into said body cavity (16), a first coupling member (26) connected to one of the rod member (14) and the object (12) through a flexible filament (28), and a second coupling member (24) connected to the other of the rod member and the object, said first and second coupling members being arranged for being mechanically coupled together through magnetic attraction, wherein one of the first and second coupling members forms a recess (30), the other of the first and second coupling members is configured as a key member (26), and magnetic poles of at least one of the first and second coupling members are arranged for drawing the key member into the recess along a direction perpendicular to the longitudinal direction of the rod member, wherein the key member and recess are constituted such that when the key member is drawn into the recess, an operative contact surfac
    Type: Application
    Filed: January 17, 2011
    Publication date: November 15, 2012
    Inventors: Hans Almer Middelbeek, Jozefus A.C. Smit, Marc-Antoine Driancourt, Angella Prohaczik
  • Publication number: 20120111094
    Abstract: A tube weld seam test method and device for testing a tube weld seam (32) of a flexible tube (18) for leaks having: a first pinching device (10) and a second pinching device (12) for pinching closed the flexible tube (18) at a first position (A) and at a second position (B), the weld seam to be tested being arranged between the first and second positions (A; B); a compressing mechanism arranged for partly compressing a tube section enclosed between the first and second pinching devices (10; 12); and a pressure test device (14) arranged for testing an internal pressure of said tube section in order to test the tube weld seam for leaks.
    Type: Application
    Filed: July 12, 2010
    Publication date: May 10, 2012
    Inventors: Hans Almer Middelbeek, Jozefus A.C. Smit
  • Publication number: 20120109095
    Abstract: A method for fastening a thread (24) to a tampon (10), in particular a veterinary tampon, comprising the steps of passing the thread through the tampon by means of a needle (12, 14), and knotting the loose ends of the thread, wherein that the step of passing the thread through the tampon comprises: -piercing the tampon (10) with two hollow needles (12, 14), -inserting the distal ends of the needles into a mould (20) that forms a passage (16) interconnecting the open ends of the hollow needles, feeding the thread (24) to the proximal end of one (12) of the two needles, -applying a suction pressure to the proximal end of the other (14) of the two needles, -opening the mould (20), and -withdrawing the needles (12, 14) from the tampon (10).
    Type: Application
    Filed: May 11, 2010
    Publication date: May 3, 2012
    Inventors: Hans Almer Middelbeek, Jozefus A.C. Smit
  • Publication number: 20120048764
    Abstract: The present invention pertains to a process for the preparation of an orally disintegrating tablet for administration to a human subject, the tablet containing a medicinal substance to treat a disorder of the human subject, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element having formed therein at least one cavity, cooling the solid element to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity by extracting heat from the formulation through a cavity wall by conduction, to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity, and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to the tablet itself and a package comprising such a tablet.
    Type: Application
    Filed: April 28, 2010
    Publication date: March 1, 2012
    Inventors: Hans Almer Middelbeek, Jozefus A.C. Smit, Jacobus Johannes Adriana Maria Verheezen
  • Publication number: 20120049412
    Abstract: The present invention pertains to a process for the preparation of a fast-disintegrating tablet (30) containing a medicinal substance, comprising the steps of providing a fluid formulation comprising the medicinal substance, providing a solid element (100) having formed therein at least one cavity, (101) cooling the solid element (100) to a temperature below a freezing temperature of the formulation, filling the cavity with the fluid formulation, solidifying the formulation while present in the cavity (101) to form a solid pellet comprising the medicinal substance without actively shaping the entire surface of the pellet, taking the pellet out of the cavity and drying the pellet in a vacuum to obtain the tablet. The invention also pertains to a system for performing such a process and a package containing the resulting tablet.
    Type: Application
    Filed: April 28, 2010
    Publication date: March 1, 2012
    Inventors: Hans Almer Middlebeek, Jozefus A.C. Smit