Patents by Inventor Jozi Nakagami

Jozi Nakagami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzo[.alpha.]phenazine antitumor agents
    Patent number: 4686292
    Abstract: Novel benzo[.alpha.]phenazine derivatives of the formula ##STR1## wherein R.sup.1 is hydrogen, halogen, methyl, hydroxyl or alkoxy, R.sup.2 is --COOR.sup.5 (wherein R.sup.5 is hydrogen, straight or branched chain alkyl, cycloalkyl having 3-6 carbon atoms, benzyl or phenyl) or ##STR2## wherein R.sup.6 and R.sup.7 are the same or different and are each hydrogen or lower alkyl, or R.sup.6 and R.sup.7 together with the nitrogen atom to which they are attached form pyrrolidine or piperidine), R.sup.3 and R.sup.4 are the same or different and are each hydrogen or lower alkyl, and n is an integer of 2 or 3, and the salts thereof are disclosed. These compounds have antitumor activity in mammals.
    Type: Grant
    Filed: March 10, 1986
    Date of Patent: August 11, 1987
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Yoshihiro Migita, Tadashi Eguchi, Yukinari Kumazawa, Jozi Nakagami, Takehiro Amano, Kaoru Sota, Jinsaku Sakakibara
  • Method for selective methylation of erythromycin A derivatives
    Patent number: 4672109
    Abstract: A method for the selective methylation of a hydroxy group at the 6-position of an erythromycin A derivative which comprises converting an erythromycin A derivative into an erythromycin A 9-oxime derivative, and reacting the resulting ethythromycin A 9-oxime derivative with an methylating agent.
    Type: Grant
    Filed: April 5, 1985
    Date of Patent: June 9, 1987
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Yoshiaki Watanabe, Shigeo Morimoto, Masami Goi, Morihiro Mitsukuchi, Takashi Adachi, Jozi Nakagami, Toshifumi Asaka, Tadashi Eguchi, Kaoru Sota
  • Novel hydrocortisone derivative
    Patent number: 4290962
    Abstract: 17.alpha.-butyryloxy-11.beta.-hydroxy-21-propionyloxy-4-pregnen-3,20-dione, i.e., hydrocortisone 17-butyrate 21-propionate of the present invention is prepared by acylating hydrocortisone 17-butyrate with propionic acid anhydride or halide. The compound of the present invention has excellent anti-inflammatory effect, percutaneous absorption and less side effect.
    Type: Grant
    Filed: March 26, 1979
    Date of Patent: September 22, 1981
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Yasuhide Tachi, Kazuhiko Michishita, Jozi Nakagami, Jiro Sawada, Mitsunori Washitake, Yoshiaki Kamano