Patents by Inventor Jozsef Bodi

Jozsef Bodi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11168368
    Abstract: The invention relates to a non-invasive, simple, inexpensive, quick method to assess embryo competence in vitro by detecting nucleic acid-containing extracellular vesicles in the culture medium of the embryo. The culture medium may be fixed before being stained with propidium iodide and analysed by flow cytometry.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: November 9, 2021
    Assignees: Pécsi Tudományegyetem, Semmelweis Egyetem
    Inventors: Éva Pállinger, Júlia Szekeres, Zoltán Bognár, Krisztina Gödöny, József Bódis, Edit Buzás
  • Patent number: 10859567
    Abstract: The non-invasive method of assessing the reducing potential of culture medium of in vitro cultured embryos as part of an ART procedure serves as an alternative or supportive method to assess the viability of in vitro cultured embryos without doing any harm to the embryos.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: December 8, 2020
    Assignee: Pécsi Tudományegyetem
    Inventors: Gergely Montskó, Gábor Kovács, József Bódis
  • Publication number: 20200369997
    Abstract: A device and method for protecting cells, gametes, embryos, and oocytes from the harmful effect of illumination. The device is a culture dish that is optimized to create a dark environment inside of the dish. The culture dish features a base, an exterior wall connected to the outer rim of the base that forms an enclosure, and a lid connected to the exterior wall. The dish is preferably made of polystyrene and lid is preferably made of aluminum foil. The method features the following steps: reducing a room exposure to sunlight, where the cells and embryos are located; covering the room ceiling lighting with color filter-luminaires; shielding the transparent surfaces of the applied aspiration set and test tube from light; applying a colored red-light filter to the IVF workstation; and incubate cells and embryos in a light-protected place.
    Type: Application
    Filed: May 21, 2020
    Publication date: November 26, 2020
    Inventors: Jozsef BODIS, Krisztina GODONY
  • Publication number: 20180274030
    Abstract: The invention relates to a non-invasive, simple, inexpensive, quick method to assess embryo competence in vitro by detecting nucleic acid-containing extracellular vesicles in the culture medium of the embryo. The culture medium may be fixed before being stained with propidium iodide and analysed by flow cytometry.
    Type: Application
    Filed: November 25, 2016
    Publication date: September 27, 2018
    Inventors: Éva PÁLLINGER, Júlia SZEKERES, Zoltán BOGNÁR, Krisztina GÖDÖNY, József BÓDIS, Edit BUZÁS
  • Publication number: 20170102377
    Abstract: The non-invasive method of assessing the reducing potential of culture medium of in vitro cultured embryos as part of an ART procedure serves as an alternative or supportive method to assess the viability of in vitro cultured embryos without doing any ham to the embryos.
    Type: Application
    Filed: July 20, 2015
    Publication date: April 13, 2017
    Inventors: Gergely MONTSKÓ, Gábor KOVÁCS, József BÓDIS
  • Publication number: 20170002414
    Abstract: The invention provides an in vitro method for non-invasive preimplantation assessment of an embryo by comprising amplifying and detecting a nucleic acid sequence of interest indicative of a genetic deficiency from a sample taken from the in vitro culture medium of the embryo and assessing the embryo as having a genetic deficiency if the presence of the sequence of interest is detected in the in vitro culture medium of the embryo. The examples show the detection of SNPs relating to the genes MDR1 and prothrombin and the SNP responsible for the Leiden syndrome. The application also mentions the possibility of establishing short tandem repeat (STR) marker profiles of DNA in the culture medium and full genome sequencing of the DNA in the culture medium as a means for determining embryo quality.
    Type: Application
    Filed: January 30, 2015
    Publication date: January 5, 2017
    Inventors: József BÓDIS, L. Gábor KOVÁCS, István VERMES, Csaba FEKETE, Orsolya RIDEG, Zoltán Endre BIHARI, Ferenc Péter PACH, Emese BATÓ, Ildikó PAPP, Bence GÁLIKK, Csaba SZERZÖ
  • Patent number: 8309712
    Abstract: The invention relates to an industrial process for the preparation of 17-hydroxy-6?,7?;15?,16?-bismethylene-3-oxo-17?-pregn-4-ene-21-carboxylic acid ?-lactone of formula (I), and to the key-intermediates for this process.
    Type: Grant
    Filed: October 11, 2005
    Date of Patent: November 13, 2012
    Assignee: Richter Gedeon Nyrt.
    Inventors: Béla Sörös, Judit Horváth, György Gálik, József Bódi, Zoltán Tuba, Sándor Mahó, Gábor Balogh, Antal Aranyi
  • Patent number: 8183402
    Abstract: The present invention relates to a process for the synthesis of the 17-acetoxy-11?-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione of formula (I): from 3,3-[1,2-etandiyl-bis(oxy)]-oestr-5(10),9(11)-dien-17-one of formula (II):
    Type: Grant
    Filed: June 19, 2008
    Date of Patent: May 22, 2012
    Assignee: Richter Gedeon Nyrt.
    Inventors: József Bódi, György Visky, János Széles, Sándor Mahó, Csaba Sánta, János Csörgei, Zoltán Tuba, László Terdy, Csaba Molnár, Antal Aranyi, Zoltán Horváth, Gábor Balogh
  • Patent number: 8178665
    Abstract: A process for the production of 1-(4-3(R)-[3(S)-(4-fluorophenyl)-3-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone (ezetimibe) according to the following reaction scheme: (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), (XI) where the substances of the general Formulas II, IV, VI, VIII, IX, X and XI are new, Formula III is a non-isolated intermediate, R1, R2 and R3 are represented by the compounds of Formulas Va-Vd, (Va), (Vb), (Vc), (Vd) and R4 is a silyl, e.g., tert-butyl-dimethyl-silyl, tert-butyl-diphenyl-silyl group.
    Type: Grant
    Filed: December 18, 2006
    Date of Patent: May 15, 2012
    Assignee: Richter Gedeon Nyrt.
    Inventors: József Bódi, János Éles, Katalin Szöke, Krisztina Vukics, Tamás Gáti, Krisztina Temesvári, Dorottya Kiss-Bartos
  • Publication number: 20100137622
    Abstract: The present invention relates to a process for the synthesis of the known 17-acetoxy-11-?-[4-(dimethyl amino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione (further on CDB-4124) of formula (I) from 3,3-[1,2-ethandiyl-bis(oxy)]-oestr-5(10),9(11)-dien-17-one of formula (II). Compound CDB-4124 belongs to the group of anti-hormones.
    Type: Application
    Filed: June 19, 2008
    Publication date: June 3, 2010
    Inventors: József Bódi, György Visky, János Széles, Sándor Mahó, Csaba Sánta, János Csörgei, Zoltán Tuba, László Terdy, Csaba Molnár, Antal Aranyi, Zoltán Horváth, Gábor Balogh
  • Publication number: 20090216009
    Abstract: An industrially easily realizable and economical process comprising only few steps, and built on new intermediates for the production of 1-(4-3(R)-[3(S)-(4-fluorophenyl)-3-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone (ezetimibe) according to the reaction scheme described herein.
    Type: Application
    Filed: December 18, 2006
    Publication date: August 27, 2009
    Inventors: Jozsef Bodi, Janos Eles, Katalin Szoke, Krisztina Vukics, Tamas Gati, Krisztina Temesvari, Dorottya Kiss-Bartos
  • Publication number: 20080200668
    Abstract: The invention relates to an industrial process for the preparation of 17-hydroxy-6?,7?;15?,16?-bismethylene-3-oxo-17?-pregn-4-ene-21-carboxylic acid ?-lactone of formula (I), and to the key-intermediates for this process.
    Type: Application
    Filed: October 11, 2005
    Publication date: August 21, 2008
    Inventors: Bela Soros, Judit Horvath, Gyorgy Galik, Jozsef Bodi, Zoltan Tuba, Sandor Maho, Gabor Balogh, Antal Aranyi
  • Patent number: 7005527
    Abstract: The present invention relates to a new process for the preparation of beraprost of formula (I) using new intermediates.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: February 28, 2006
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
    Inventors: Tibor Szabo, Jozsef Bodi, Gyuia Dalmadi, Zsusanna Baloghnekardos, Zoltan Szevfrenyi
  • Publication number: 20040209945
    Abstract: The present invention relates to a new process for the preparation of beraprost of formula (I) using new intermediates.
    Type: Application
    Filed: April 1, 2004
    Publication date: October 21, 2004
    Inventors: Tibor Szabo, Jozsef Bodi, Gyuia Dalmadi, Zsusanna Baloghnekardos, Zoltan Szevfrenyi