Patents by Inventor Jozsef Törley

Jozsef Törley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF CHIRALLY PURE NATEGLINIDE
    Publication number: 20100256414
    Abstract: The invention relates to N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine (nateglinide) in the novel crystalline form “G” and a process for the preparation thereof. A process for the preparation of chirally pure nateglinide by treating a lower alkyl ester thereof with a base to yield an alkali salt and liberating the product from said salt by proper addition of an acid, is also provided. Still another aspect of the invention is a process for the preparation of nateglinide in the crystalline form “H” from other crystalline modifications of nateglinide.
    Type: Application
    Filed: April 7, 2010
    Publication date: October 7, 2010
    Inventors: Maria Gazdag, Tibor Gizur, Bela Hegedus, Attila Szemzo, Gabor Tarkanyi, Jozsef Törley, Monika Babjak
  • Process for the preparation of chirally pure N-(trans-4-is)
    Patent number: 7767847
    Abstract: The invention relates to N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine (nateglinide) in the novel crystalline form “G” and a process for the preparation thereof. A process for the preparation of chirally pure nateglinide by treating a lower alkyl ester thereof with a base to yield an alkali salt and liberating the product from said salt by proper addition of an acid, is also provided. Still another aspect of the invention is a process for the preparation of nateglinide in the crystalline form “H” from other crystalline modifications of nateglinide.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: August 3, 2010
    Assignee: Richter Gedeon Vegyeszeti Gyar RT.
    Inventors: Maria Gazdag, Tibor Gizur, Bela Hegedus, Attila Szemzo, Gabor Tarkanyi, Jozsef Törley, Monika Babjak
  • Industrial process for the synthesis of 2-substituted 1-(hydroxy-ethylidene)-1,1-bisphosfi- conic acids of high purity and the salts thereof
    Patent number: 7612229
    Abstract: Process for the synthesis of high purity 2-substituted-1-(hydroxy-ethylidene)-1,1-bisphosphonic acid of formula (I), the salts and hydrates thereof—wherein the meaning of R is 3?-pyridyl or 2?-amino-ethylidene group—from compounds of formula (II)—wherein the meaning of R is as described above—or salts and hydrates thereof with phosphorous acid in the presence of methanesulfonic acid using phosphorus pentoxide as reagent and in given case the obtained acid is converted into a salt with base.
    Type: Grant
    Filed: January 27, 2004
    Date of Patent: November 3, 2009
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Jozsef Neu, Janos Fischer, Tamas Fodor, Jozsef Törley, Tibor Gizur, Sandor Levai, Adam Demeter, Eva Perenyi
  • Process for the synthesis of high purity 3,5-diamino-6-(2,3-dichlorophenyl) (1,2,4-triazine)
    Patent number: 7390899
    Abstract: The present invention relates to a new process for the synthesis of high purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine of formula (I) using 2,3-dichlorobenzoyl cyanide and an aminoguanidine salt as starting materials. 2,3-dichlorobenzoyl cyanide is reacted with 1-2 mol equivalent of aminoguanidine salt in 3-6 mol equivalent of methanesulfonic acid, then the obtained adduct of formula (IV) is transformed without isolation into the product with magnesium oxide.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: June 24, 2008
    Assignee: Richter Gedeon Vegyeszeti Gyar. RT.
    Inventors: Jozsef Neu, Tibor Gizur, Jozsef Törley, Janos Csabai, Ferenc Vegh, Peter Kalvin, Gabor Tarkanyi