Abstract: Disclosed are solid forms of an inhibitor of glycine transporter-1 (GlyT1). The invention also relates to methods of making these solid forms, pharmaceutical compositions comprising these solid forms, and their use for medical conditions responsive to treatment with an inhibitor of glycine transporter-1.

Abstract: The invention describes a process for reworking of a crystallization product comprising drying and homogenization. The crystallization product is crystalline [5-(methylsulfonyl)-2-{[(2R)-1,1,1-trifluoropropan-2-yl]oxy}phenyl]{(1R,5R)-1-[5-(trifluoromethyl)-1,2-oxazol-3-yl]-3-azabicyclo[3.1.0]hex-3-yl}methanone. The product is dried in a tray dryer or in a pan dryer and subsequently homogenized.

Abstract: Disclosed are solid forms of an inhibitor of glycine transporter-1 (GlyT1). The invention also relates to methods of making these solid forms, pharmaceutical compositions comprising these solid forms, and their use for medical conditions responsive to treatment with an inhibitor of glycine transporter-1.

Abstract: A chamber sealing mechanism and a pressurization bubble-eliminating equipment are provided. The chamber sealing mechanism includes an annular groove and a sealing ring, wherein the sealing ring and the annular groove are connected to form a closed cavity; the annular groove is provided with a gas charging valve that communicates with the closed cavity and is configured to charge air into the closed cavity and discharge air from the closed cavity.

Abstract: A securing apparatus configured to mount a data storage device in an enclosure includes a shielding assembly configured to be secured to a panel of the enclosure and a sliding pole. The shielding assembly includes a frame and a rotating plate rotatably mounted to the frame. The sliding pole is slidably mounted to the frame and defines a plurality of latching slots. The frame defines an aperture for the data storage device to pass through; the rotating plate comprises a plurality of hooks. The sliding pole is slidable relative to the frame to engage the hooks in the latching slots. The rotating plate is secured to the frame and shields the aperture, preventing the data storage device from being taken out of the enclosure.

Abstract: A securing apparatus configured to mount a data storage device in an enclosure includes a shielding assembly configured to be secured to a panel of the enclosure and a sliding pole. The shielding assembly includes a frame and a rotating plate rotatably mounted to the frame. The sliding pole is slidably mounted to the frame and defines a plurality of latching slots. The frame defines an aperture for the data storage device to pass through; the rotating plate comprises a plurality of hooks. The sliding pole is slidable relative to the frame to engage the hooks in the latching slots. The rotating plate is secured to the frame and shields the aperture, preventing the data storage device from being taken out of the enclosure.

Abstract: A chamber sealing mechanism and a pressurization bubble-eliminating equipment are provided. The chamber sealing mechanism includes an annular groove and a sealing ring, wherein the sealing ring and the annular groove are connected to form a closed cavity; the annular groove is provided with a gas charging valve that communicates with the closed cavity and is configured to charge air into the closed cavity and discharge air from the closed cavity.

Abstract: The present invention relates to a process of making a compound of formula (XII) or (XIIA): wherein R1,R2, R4 and X are as defined herein.

Abstract: The present invention relates to a process of making a compound of formula (I): Wherein, R1, R2, R4 and X are as defined herein.

Abstract: The present invention relates to a process of making a compound of formula (XII) or (XIIA): wherein R1, R2, R4 and X are as defined herein.

Abstract: A light-emitting diode lamp for emitting light in nearly all directions has a lamp holder, an LED power supply, a cylindrical surface-mounted device (SMD) LED light source, a lamp shade, a metal connecting piece, a metal radiator and a flame-retardant plastic connecting piece. The LED light source is fixed in the flame-retardant plastic connecting piece; an upper portion of the flame-retardant plastic connecting piece is mechanically fixed with the lamp holder and a lower portion is mechanically fixed with the lamp shade through the metal radiator; one end of the metal connecting piece is fixed with the metal radiator and the other end is extended into the lamp shade; the cylindrical SMD LED light source is adhered to an outer side surface of a portion of the metal connecting piece extended into the lamp shade; and the lamp holder.

Abstract: Embodiments of the invention describe providing image focusing capabilities for a lens unit of an image capture system by disposing a solid state die over the lens unit. The solid state die may include a plurality of electrodes to receive a voltage or electric signal to generate an electric field. The refractive index of the solid state die will change in response to the generated electric field to focus the image or scene captured by the lens unit. The solid state die is mounted to a folded flexible printed circuit board in a housing or a molded housing having electrodes on its inner wall.

Abstract: An AC, rf, or pulse-excited microdischarge device and array are provide by the invention. A preferred array includes a substrate. A plurality of microdischarge cavities that contain discharge medium are in the substrate. A transparent layer seals the discharge medium in the microdischarge cavites. Electrodes stimulate the discharge medium. The microdischarge cavities are physically isolated from the electrodes by dielectric and arranged relative to the electrodes such that ac, rf, or pulsed excitation applied to the electrodes stimulates plasma excitation of the discharge medium. The microdischarge cavities are sized to produce plasma within the microdischarge cavities.

Abstract: The present invention is directed to an improved process for the preparation of Compounds of Formula (I) or salts thereof which are useful in the treatment of HIV infection. In particular, the present invention is directed to an improved process for the preparation of (2S)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid or salt thereof which is useful in the treatment of HIV infection.

Abstract: The present invention is directed to an improved process for the preparation of Compounds of Formula (I), which are useful in the treatment of HIV infection. In particular, the present invention is directed to an improved process for the preparation of (2S)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid, which is useful in the treatment of HIV infection.

Abstract: Compounds of formula (I), or a pharmaceutically acceptable salt, prodrug, salt of a prodrug, or a combination thereof. Pharmaceutical compositions of formula (I) and related methods for treating or preventing metabolic diseases or conditions.

Abstract: The present invention relates to a process of making a compound of formula (I): Wherein, R1, R2, R4 and X are as defined herein.

Abstract: Disclosed are syntheses of 11?-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).

Abstract: A high intensity discharge arc lamp comprises an arc tube, a metal halide in the arc tube, and a coating on the arc tube. The coating comprises a UV absorbent material.

Abstract: Embodiments of the invention describe providing image focusing capabilities for a lens unit of an image capture system by disposing a solid state die over the lens unit. The solid state die may include a plurality of electrodes to receive a voltage or electric signal to generate an electric field. The refractive index of the solid state die will change in response to the generated electric field to focus the image or scene captured by the lens unit. The solid state die is mounted to a folded flexible printed circuit board in a housing or a molded housing having electrodes on its inner wall.